Up to 50% of children born SGA to 2 years have not made a proper catch up (by excess or defect), with repercussions in size, metabolic and cardiovascular disorders, DM, etc. epiPEG-PreMeb project to study during their first two years of life.
Goals:: Establish a SGAcohort for monitoring, evaluation catch-up, and analysis of medium-environmental and social factors. To study the influence of these variables on clinical, laboratory and metabolic profiles. Somatometry draw graphs and tables of biochemistry normal. Create a serum bank for future biochemical and genetic studies.
Material and methods: They studied live births of singletons in our hospital during 20122014, and are classified according to EG and weight/height (Spanish Tables 2008). Estimated N: 110 visits are made at 0, 3, 6, 9, 12, 15, 18 and 24 months, measurements, weight, height and perimeters. blood samples analyzed and store are obtained. Results at the end of the initial selection: SGA103 recruited in 24 months (♂56, 55%). Epidemiological data: Average age 32.2 years mother brothers 18/103 previous PEG (17%); smoking mothers during pregnancy 40/103 (38%), 4 (315) cigarettes/day; worker during pregnancy 67/103 (65%), of which 85% relate with> 3 hours walking/day; drugs during pregnancy 29/103 (28%), 70% for asthma, 20% l-thyroxine and 10% other. Pathologies associated with gestation: 54/103 (52%) (gestosis, preeclampsia, DM, thyroiditis, psychogenic stress). Childbirth: a term 67/103 (65%), eutocic 88/103 (85%). Facts children at birth: Middleweight DS −2.7 [−3.5 to 2.0], medium size DS −2.4 [−3.2 to 2.1], for sex, and EG. EBF: 77/103 (74%) during the 1st month of life. RN income or pathology in the 1st month of life 24/103 (23%). SGAcases that have reached 12 months of follow up 62 cases. Income over 12 months 5/62 (8%) (bronchitis). With 12 months of life have 10/62 cases (16%) no suitable catch up with P and/or T <P10, 32/62 cases (48%) catch up very fast with P and/or T> P90.
Conclusions: The age of pregnant women, their current lifestyle (snuff, stress and work) and taking regular medication (asthma), is causing a higher rate of SGA. In our study it notes that about women Euskadi rate of pregnant women with SGA smokers is higher and younger age. These children PEG require greater use of artificial feeding, a higher rate of hospital admissions of children with birth SGA, but later is not a disease risk population, or bronchiolitis. However it detected since 70% of RN PEG have an inadequate development somatosensory metric per year of life, which may have future repercussions.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology