ESPE Abstracts (2016) 86 RFC4.7

ESPE2016 Rapid Free Communications Pathophysiology of Obesity (6 abstracts)

Prevalence and Characterization of Retinal Alterations in a Cohort of Overweight and Obese Children

Stefania Pedicelli a , Carla Bizzarri a , Antonino Romanzo b , Stefano Cianfarani c, & Marco Cappa a

aUnit of Endocrinology and Diabetes, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; bOphtalmology Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; cMolecular Endocrinology Unit, Bambino Gesù Children’s Hospital-Tor Vergata University, Rome, Italy; dDepartment of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden

Background: Increasing incidence of pediatric obesity has been observed worldwide. Metabolic syndrome, characterized by visceral obesity, dyslipidemia, hypertension and impaired glucose metabolism, is associated with obesity.

Objective and hypotheses: To evaluate early ocular signs of hypertension by retinography in a cohort of overweight (BMI>85th)/obese (BMI>95th) children, in order to define the prevalence of retinal alterations and characterize the patients.

Method: All subjects underwent retinography, anthropometric examination, blood pressure measurement, oral glucose tolerance test (OGTT), lipid profile assessment, ECG and DEXA scan to evaluate body composition. The same paediatric endocrinologist examined all patients and all retinographies were evaluated by the same ophthalmologist.

Results: A total of 115 children (59 males) aged 12.83±1.96 years were included in the study: 105 patients (91.3%) showed normal retinographic pattern or aspecific retinal vessel alterations (Group A), 7 (6.1%) showed signs of hypertensive retinopathy (in 1 case papilledema) representing Group B, and the remaining 3 (2.6%) had different alterations, as coloboma or choroidal nevus. In the comparison between Group A and B, the latter showed significant higher values in BMI (29.9±3.5 vs 33.4±6.3 kg/m2; P=0.018), BMI SDS (2.5±0.7 vs 3.3±1.4; P=0.006), abdominal circumference (CA) (100.9±10.4 vs 109.6±15.3 cm; P=0.042), wrist circumference (17.3±1.1 vs 18.4±2.1 cm; P=0.024), CA/height ratio (0.6±0.0 vs 0.7±0.1; P=0.007) and glycemia at 120’ during OGTT (110.1±19.9 vs 128.9±25.0; P=0.019). No significant differences in blood pressure or between sexes were found. Interestingly, 3/7 patients of Group B were overweight but not obese. All but one retinographies with alterations were detected in pubertal patients. The only prepubertal child with altered retinography had a complex form of obesity and is currently being studied. No ECG alterations were found in Group B.

Conclusion: Retinal alterations could represent early signs of hypertension in children with overweight and obesity, even when blood pressure appears normal at routine measurements.

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