ESPE Abstracts (2016) 86 WG2.3

Clinical Approach To Severe Early Onset Childhood Obesity

Gabriel Á. Martos-Moreno

Madrid, Spain

The increase in childhood obesity prevalence led to the establishment of a monographic obesity clinic since 2009 in our Department. To date, over 1600 patients have been visited, focusing on early onset severity and generating a valuable dataset on the characteristics of these patients (“The Madrid cohort”). This has allowed the performance of genomic and genetic studies, which have led to the demonstration of a genetic background, underlying the development of the disease in a number of these patients (also detailed in FC 4.1 in this meeting). On the other hand, we have been able to analize the clinical, anthropometrical and metabolic characteristics of 1300 children affected with non-syndromic nor genetic (thus, common or polygenic) obesity at diagnosis, as well as the singularities of their follow up. As a result, we will expose their growth, pubertal and skeletal maturation status at diagnosis, according to their sex, age and race, and how they evolve during their evolution; analyzing whether there are singularities in the timing and tempo of pubertal events. Metabolic comorbidities have been thoroughly investigated both, with the diagnostic procedures usually used in the clinic (including the detailed analysis of glycemia and insulinemia in the OGTT test in over 800 patients) as also from the new perspective offered by the “omic” sciences, showing the existence of early proteomic and metabolomic impairment in young obese children, particularly in the presence of insulin resistance. Finally, an overview of the main features of the clinical follow-up of these patiens (drop-out, reconsultation rates) as well as the success rate and later BMI and metabolic evolution will be displayed.

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