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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

Free Communications

Fat, Metabolism and obesity

hrp0089fc6.1 | Fat, Metabolism and obesity | ESPE2018

Correlations Between Measures of Adiposity Across Childhood and Adolescence and the Intestinal Microbiota in 15-17 year-old Children with a Family History of Obesity: Preliminary Findings from the QUALITY Cohort

Henderson Melanie , Van Hulst Andraea , Simoneau Gabrielle , Barnett Tracie A. , Drapeau Vicky , Mathieu Marie-Eve , Nicolau Belinda , Varin Thibaut , Marette Andre

Background: While differences in gut microbiota between obese and lean subjects have been described, few studies have examined how adiposity across childhood relates to intestinal microbiota composition and diversity in late adolescence.Objective: To explore the correlations between measures of adiposity from childhood and adolescence with intestinal microbiota composition and diversity at 15–17 years.Methods: Data stem from t...

hrp0089fc6.2 | Fat, Metabolism and obesity | ESPE2018

Impaired Brain Satiety Responses to a Meal in Children with Obesity

Roth Christian , Melhorn Susan , Elfers Clinton , Scholz Kelley , De Leon Mary Rosalynn , Saelens Brian , Schur Ellen

Behavioral studies suggest that brain satiety responses to food consumption are altered in children with obesity. We studied brain regions involved in satiety processing using functional magnetic resonance imaging (fMRI) before and after a test meal. Satiety-related hormonal changes were assessed. Fifty-four 9-11 year-old children with obesity (OB) and 22 children with healthy weight (HW) were studied. Subjects underwent two fMRI scans, one before and one after a test meal, an...

hrp0089fc6.3 | Fat, Metabolism and obesity | ESPE2018

Role of PTEN in the Proliferation and Differentiation of Preadipocytes

Kirstein Anna , Kassner Franziska , Schmid Gordian L. , Handel Norman , Penke Melanie , Kiess Wieland , Garten Antje

Background/aim: The PTEN hamartoma tumor syndrome (PHTS) is an overgrowth syndrome caused mainly by germline mutations in the tumor suppressor PTEN. Patients are predisposed for the development of malignant and benign tumors. Children and adolescents with PHTS frequently develop single or multiple lipomas. PTEN antagonizes the phosphatidylinositide3-kinase/AKT/mechanistic target of rapamycin (PI3K/AKT/mTOR) pathway, which promotes proliferation and differentiation in ...

hrp0089fc6.4 | Fat, Metabolism and obesity | ESPE2018

Identification of the First Obesity-Associated Mutations in Human Mesoderm-Specific Transcript (MEST) Result in Protein Overexpression, Adipocyte Hypertrophy and a Reduction in Adipocyte Mitochondrial Area

Suarez Juan , Martos-Moreno Gabriel , Rivera Patricia , Serra-Juhe Clara , Chowen Julie , Perez-Jurado Luis , Argente Jesus

Background: Mesoderm-specific transcript (MEST) is an epoxide α/β-hydrolase protein with catalytic activity that is determinant for the development of adipocytes. The MEST gene is an imprinted gene transcribed only from the paternal allele. Although the mechanism by which MEST overexpression augments fat accumulation and storage in adipocytes has not been fully elucidated, frequent subcellular contacts between MEST-positive endoplasmic reticulum, mi...

hrp0089fc6.5 | Fat, Metabolism and obesity | ESPE2018

The Role of Adipocytes in Childhood Precursor Bcell Lymphoblastic Leukemia

Brenner Elena Dorothea , Zinngrebe Julia , Dahlhaus Meike , Meyer Lueder-Hinrich , Wabitsch Martin , Debatin Klaus-Michael , Fischer-Posovszky Pamela

Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in childhood. Over the past decades, survival rates increased, but relapse is still associated with a poor prognosis, especially if the bone marrow (BM) is affected. Marrow adipose tissue (MAT) constitutes a major part of the BM niche, but its impact on normal hematopoiesis versus leukemia initiation, progression and relapse has only recently gained attention. MAT is very sensitive to changes in the patient’s...

hrp0089fc6.6 | Fat, Metabolism and obesity | ESPE2018

MicroRNA-141 Directly Targets and Inhibits Sirtuins 1 Gene Expression and Its Elevation in Obese Subjects is Responsible for Reduced Levels of Sirtuin 1 and the Subsequent Hepatic Steatosis and Insulin Resistance

Nourbakhsh Mitra , Yousefi Zeynab , Nikroo Nikta Dadkhah , Malek Mojtaba , Pazouki Abdolreza , Mokhber Somayye

Introduction: Obesity increases the risk of various disorders including diabetes, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disorders. MicroRNAs (miRNA) are single-stranded, non-coding oligonucleotides that regulate gene expression. Sirtuin 1 (SIRT1), a regulatory enzyme in metabolic homeostasis, is regulated by miRNAs. The aim of this study was to evaluate miR-141 in obesity and whether this miRNA can regulate SIRT1 expression.Materia...