ESPE2018 Poster Presentations Diabetes & Insulin P3 (60 abstracts)
Continuous Subcutaneous Insulin Infusion in Children and Adolescents: Analysis of Initial and Follow Up Basal Rates
Gunay Demir , Sukran Darcan , Samim Özen , Hafize Işıklar , Yasemin Atik Altınok & Damla Goksen
Ege University Faculty of Medicine Departement of Ped Endocrinology and Diabetes, İzmir, Turkey
Objective: Initiation of continuous subcutaneous insulin therapy (CSII) requires an appropriate basal rate profile. Although different approaches exist; there is a lack of evidence-based recommendations, especially in young children. Our aim was to show how the % of basal rates change at the end of first year of therapy when basal rates are equally distributed at the start of therapy.
Materials and Methods: In this survey, 129 CSII patients were analyzed. Patients were divided into four age groups: <5 yr (n=27), 5 to < 8 yr (n=20), 8 to <12 yr (n=33), 12 to <15 yr (n=28), 15 to < 18 yr (n=16) and > 18 yr (n=5). Basal insulin requirement and diurnal distribution were evaluated at the initiation of pump therapy and in the first year.
Results: Basal insulin requirement did not differ between the beginning of therapy and first year (Table 1). In every age group basal insulin (U/kg) circadian insulin profiles were different except in the group 12 to <15 yr. As a result, at the start of pump therapy basal rates should be designed according to circadian rhythm.
| Basal İnsulin beginning U/kg | 1 st Year Basal insulin U/kg | p | |
| 0–5 yr n:27 | 0.41±0.88 | 0.26±0.68 | 0.13 |
| 5–8 yr n:20 | 0.29±0.12 | 0.30±0.09 | 0.50 |
| 8–12 yr n:33 | 0.31±0.13 | 0.32±0.09 | 0.27 |
| 12–15 yr n:28 | 0.33±0.08 | 0.35±0.09 | 0.34 |
| 15–18 yr n:16 | 0.32±0.10 | 0.34±0.11 | 0.43 |
| >18 yr n:5 | 0.22±0.05 | 0.24±0.06 | 0.5 |
| pa | 0.006 | 0.002 | |
| p: basal and first year change pa: change according to age groups. | |||
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