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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

Poster Presentations

Diabetes & Insulin P3

hrp0089p3-p071 | Diabetes & Insulin P3 | ESPE2018

Multiple Autoimmune Association and Varied Spectrum of Presentation in Indian Diabetic Children

Sethi Aashish , Ramachandran Smita , Kochar Inderpal

Objective: To define the prevalence of autoantibodies at presentation in children with type 1 diabetes and to determine the associated comorbid autoimmune conditions in Indian pediatric patients.Materials and Methods: Children (n=468) diagnosed with type 1 diabetes at Indraprastha Apollo Hospital, Delhi, India for childhood Diabetes were screened for autoimmune thyroid disease (thyroid peroxidase autoantibodies [TPOAb]), celiac disease (tissue t...

hrp0089p3-p072 | Diabetes & Insulin P3 | ESPE2018

Severe Hypertriglyceridemia and Multiple Autoimmune Phenomenon at new onset Type 1 DM

Sethi Aashish , Ramachandran Smita , Kochar Inderpal

Introduction: Type 1 Diabetes is a condition associated with deficiency of insulin, which is a key regulator of carbohydrate and fat metabolism. Most newly diagnosed type 1 diabetes present with diabetic ketoacidosis, which is a triad of hyperglycemia, ketonemia and acidosis. It usually presents with features of acidosis such as lethargy, dehydration, and tachypnea.Case: We present a case that presented to us with a lipemic blood sample and on further wo...

hrp0089p3-p073 | Diabetes & Insulin P3 | ESPE2018

Effects of Diabetes Mellitus Type-1 on Vitamin D Status Among Children

Alshareef Abeer

Introduction: Vitamin D defciency is a common health concern among all children world wide.together with the rapidly increased prevalence of diabetes mellitus\.This study was conducted to determine if diabetes is associated with increased risk of vitamin D deficiencydy examination the influences of diabetes effecting status on specific patients disease characteristics in regards to vitamin D level among children from saudi arabia.Methods: All retrospecti...

hrp0089p3-p074 | Diabetes & Insulin P3 | ESPE2018

Association between Prior Toxic Stressors and Development of T2DM in Adolescents

Adamidis Adam , Knee Alexander , Cobb Victoria , Conroy Rushika

Background: Low stress resilience in late adolescence and psychosocial traumatic events in adulthood have been linked to a higher risk of developing type 2 diabetes (T2DM) later on in life. However, limited data is available regarding whether prior stressors are related to the risk of developing T2DM in adolescence.Objective: We sought to determine the potential association between prior toxic stressors and T2DM in adolescence.Desi...

hrp0089p3-p075 | Diabetes & Insulin P3 | ESPE2018

First Four Cases of Neonatal Diabetes from Kazakhstan, Almaty with Proven Mutations in KCNJ11 and INS Genes

Nurbekova Akmaral , Hattersley Andrew , Ten Svetlana , Bhangoo Amrit

We report three cases of neonatal diabetes from Kazakhstan, Almaty with the KCNJ11 gene mutation who were successfully switched from insulin to sulphonylurea treatment and 1 case of insulin (INS) gene mutation that presented as permanent insulin dependent neonatal diabetes.Case 1: An 1 month old girl presented with elevated glucose level, dehydation, ketoacidosis and was treated with Insulin. HbA1c at diagnosis was 10%. Heterozygous missense mut...

hrp0089p3-p076 | Diabetes & Insulin P3 | ESPE2018

First 2 Cases of Monogenic Diabetes (MODY) from Kazakhstan, Almaty with Proven Heterozygous Mutation in Hepatocyte Nuclear Factor 1-Alpha (HNF1A) Gene

Nurbekova Akmaral , Hattersley Andrew , Ten Svetlana , Bhangoo Amrit

Background: It is important to make correct diagnosis of monogenic diabetes or MODY in children. Most of the patients are misdiagnosed with diabetes type 1 or type 2 and undergo unnecessary treatment with insulin or oral medications. We report first 1 case of MODY with heterozygous mutation in HNF1A gene when Insulin treatment was changed to sulphonylurea treatment and 1 case of compound heterozygote of glucokinase (GCK) gene and HNF1A gene mutations.Cas...

hrp0089p3-p077 | Diabetes & Insulin P3 | ESPE2018

Achievement of Therapy Targets in Children and Adolescents with Type 1 Diabetes Mellitus at the ‘Diabetes School’

Tashmanova Akmaral , Danyarova Laura , Rakhimova Gulnara

Aim: The work was initiated to assess efficacy of training and achievement of therapy targets in children and adolescents with type 1 diabetes mellitus in ‘Diabetes Schools’.Method: The five-day training course was conducted in ‘Type 1 Diabetes School’ at the Scientific-Research Institute of Cardiology and Internal Diseases, Kazakhstan Public Health Ministry (Almaty). The training was conducted by means of a structured program contain...

hrp0089p3-p078 | Diabetes & Insulin P3 | ESPE2018

Characteristics of MODY-GCK Diabetes in Children and Adolescents in Siberia

Ovsyannikova Alla , Rymar Oksana , Shakhtshneider Elena , Ivanoshchuk Dinara

The purpose: To identify the clinical features of MODY-GCK diabetes which we need to follow of this group of patients.Materials and methods: We examined 35 patients under the age of 18 years with impaired carbohydrate metabolism. Inclusion criteria were: diagnosed carbohydrate metabolism disorder or diabetes mellitus (DM), normal weight, family history of diabetes, no antibodies, normal or slightly decreased C-peptide level for at least 2 years, absence ...

hrp0089p3-p079 | Diabetes & Insulin P3 | ESPE2018

Clinical Case of MODY-GCK Diabetes: Heterogeneity of Course among Relatives from One Family

Ovsyannikova Alla , Rymar Oksana , Shakhtshneider Elena , Ivanoshchuk Dinara , Voevoda Mikhail

We described a family in which MODY-GCK was detected in 6 people and its course varied.Materials and methods: The diagnosis of GCK-MODY was verified by the proband and his relatives on the basis of direct automatic sequencing and sequencing by Sanger.Results: Proband – a boy of 12 years, diabetes mellitus (DM) type 1 is diagnosed at the age of 11 years. He felt polydipsia, polyuria. Body weight was normal, he has not any disea...

hrp0089p3-p080 | Diabetes & Insulin P3 | ESPE2018

Clinical and Biochemical Characteristics of Familial Type 1 Diabetes Mellitus (FT1DM) Compared to Non-Familial Type 1 DM (T1DM)

Alyafei Fawzia , Soliman Ashraf , Alkhalaf Fawziya , Sabt Amal , Waseef Reem , Eldarsy Nagwa , Abdulkayoum Anas , Umer Fareeda

Introduction: The clinical and genetic characteristics of T1D cases with and without affected family members have been previously studied with varying results. Some investigators found a similarity of presenting features whereas others reported significant differences between the two groups.Patients and methods: This was a cross sectional descriptive study to determine the clinical presentation and prevalence of beta cell autoimmunity (Anti GAD, anti-isl...

hrp0089p3-p081 | Diabetes & Insulin P3 | ESPE2018

Prevalence of Beta-cell Antibodies and Associated Autoimmune Diseases in Children and Adolescents with Type 1 (T1DM) vs Type 2 Diabetes Mellitus (T2DM) in Qatar

Alyafei Fawzia , Soliman Ashraf , Alkhalaf Fawziya , Sabt Aml , Waseef Reem , Eldarsy Nagwa , Algamal Mona

Introduction: Type 1 diabetes (T1DM) is an autoimmune disease with abnormal immune responses to specific β-cell autoantigens, resulting in insulin deficiency. Children and adolescents with T1DM may also develop organ-specific autoimmunity. The most frequently reported disorders are thyroid dysfunction and celiac disease. There are limited previous studies on the prevalence of associated autoimmunity, especially multiple, in children with T1DM.Aim: T...

hrp0089p3-p082 | Diabetes & Insulin P3 | ESPE2018

Clinical Presentation and Autoimmune Markers in Children and Adolescents with Familial Type 1 Diabetes Mellitus (FT1DM) and Familial Type 2 Diabetes Mellitus (FT2DM)

Alyafei Fawzia , Soliman Ashraf , Alkhalaf Fawziya , Sabt Amal , Waseef Reem , Aldarsy Nagwa , Algamal Mona

Studies support the existence of a genetic contribution to both type 1 and type 2 diabetes, and additionally suggest a relationship between both types of diabetes. The rapidly growing worldwide epidemic of type 2 diabetes has been partially explained by obesity and the sedentary lifestyle. However, familial factors also seem to play a major role in the pathogenesis of type 2 diabetes.). The fact that type 1 and type 2 diabetes cluster in families suggests that some patients ma...

hrp0089p3-p083 | Diabetes & Insulin P3 | ESPE2018

Real–world Clinical Evolution of Type 1 Diabetes Patients on Twenty Years

Vergaz Amparo Gonzalez , Cuartero Beatriz Garcia , Salado Laura Sanchez , Escudero Veronica Sanchez , Lacalle Concepcion Garcia , Fernandez Marta Fernandez

Introduction: Type 1 diabetes mellitus (T1DM) is a chronic disease with important complications.Objective: Describe clinical characteristics, metabolic control and comorbidities of our pediatric diabetes population.Methods: T1DM patients diagnosed from 1996–2016 were included. Celiac and thyroid disease screening were analized.Clinical and biochemical data were compared during evolution. SPSS.21 for statistical study.<p cl...

hrp0089p3-p084 | Diabetes &amp; Insulin P3 | ESPE2018

Diabetic Capilaropathy: A Case Report

Andres Carlos , Tabuenca Laura , Sanchez Idoia , Diaz Laura , Chueca Maria J , Berrade Sara , Dura Teodoro , Compains Esther

Uncontrolled diabetes mellitus is a disease with a wide range of systemic complications. Eye complications may seriously threaten quality of life. Diabetic retinopathy is the most frequent diabetic ocular complication. However, diabetic capilaropathy is a little known condition of diabetic retinopathy. It is an acute optic disc edema and/or macular edema; due to an acute hyperglycaemia.Method: We present a case of a diabetic 14-years-old female with diab...

hrp0089p3-p085 | Diabetes &amp; Insulin P3 | ESPE2018

A Sibling Case of Wolfram Syndrome with Diabetes Mellitus Diagnosed within 10 Months in Early Childhood

Suzuki Dai , Shima Hirohito , Umeki Ikumi , Kamimura Miki , Kanno Junko , Kure Shigeo , Fujiwara Ikuma

Introduction: Wolfram syndrome (WS) is a rare progressive neurodegenerative disease that shows autosomal recessive inheritance characterized by diabetes insipidus, diabetes mellitus (DM), optic nerve atrophy and deafness. WFS1 gene encoding a protein, wolframin, which is essential to the function of the endoplasmic reticulum, is identified as main causative gene of the disease. We report here a sibling case suspected WS with insulin-dependent DM and optic atrophy in early chil...

hrp0089p3-p086 | Diabetes &amp; Insulin P3 | ESPE2018

Continuous Subcutaneous Insulin Infusion in Children and Adolescents: Analysis of Initial and Follow Up Basal Rates

Demir Gunay , Darcan Sukran , Ozen Samim , Işıklar Hafize , Atik Altınok Yasemin , Goksen Damla

Objective: Initiation of continuous subcutaneous insulin therapy (CSII) requires an appropriate basal rate profile. Although different approaches exist; there is a lack of evidence-based recommendations, especially in young children. Our aim was to show how the % of basal rates change at the end of first year of therapy when basal rates are equally distributed at the start of therapy.Materials and Methods: In this survey, 129 CSII patients were analyzed....

hrp0089p3-p087 | Diabetes &amp; Insulin P3 | ESPE2018

Prevalance of Fatty Liver in Patients with Type 1 Diabetes Mellitus Attending Diabetes Clinic at Alexandria University Children’s Hospital

Fawzy Dina , Elsayed Shaymaa , Adel Abdel-Moneim Mahmoud

Background: Type 1 diabetes mellitus (T1DM) - related hepatopathy is not uncommon and tends to be more prevalent among children with poor glycemic control. Recent studies suggest that fatty liver disease may be more common in T1DM than previously thought.Aim: The aim of this work was to determine the frequency of hepatopathy in patients with type 1 diabetes mellitus attended diabetes clinic at Alexandria university children’s hospital (AUCH) and it&...

hrp0089p3-p088 | Diabetes &amp; Insulin P3 | ESPE2018

The Triad of Obesity, Acanthosis Nigricans and Diabetes Mellitus in a Newly Diagnosed Adolescent; Is This Type 1 Or Type 2 Diabetes Mellitus?

Joel Dipesalema , Ramaphane Tshireletso , Matsheng-Samuel Motlalekgomo , Nchingane Seeletso

Introduction: The incidence of type 1 and type 2 diabetes mellitus in children and adolescent has been on the rise for the last decades. While the reasons behind these are not known, one possible explanation for the emergence of type 2 diabetes in children is the increase of obesity and decreasing physical activity. Adolescents are at the cross roads between childhood and adulthood and that makes classification of their diabetes mellitus at presentation a diagnostic challenge....

hrp0089p3-p089 | Diabetes &amp; Insulin P3 | ESPE2018

A Female Patient with Atypical Diabetes Features, Showing Heterozygous Mutations on G6PC2 (Glucose 6 Phosphatase, Catalytic Subunit 2): Does Explain All Clinical Manifestations or Is It Only Polymorphism?

Ozsu Elif

A female patient with atypical diabetes features, showing heterozygous mutations on G6PC2 (Glucose 6 phosphatase, catalytic subunit 2). Does explain all clinical manifestations or is it only polymorphism?Introduction: Determing diabetes subtypes and classification is not clear for every patient and diagnosis can be difficult. Here in, we have found a quite interesting mutation on G6PC2 gene in a girl, 10 years old, showing atypical diabetes characteristi...

hrp0089p3-p090 | Diabetes &amp; Insulin P3 | ESPE2018

Clinical and Laboratory Features at the Onset of Childhood Type 1 Diabetes Mellitus in the Nortwest Region (Trakya) of Turkey

Dilek Emine , Bezen Digdem , Ozguc Comlek Fatma , Ozkaya Beyhan , Tutunculer Filiz

Aim: To describe the clinical pattern and laboratory characteristics at presentation of a group of children with type 1 diabetes mellitus living in the Northwest region (Trakya) of Turkey.Methods: The clinical and laboratory data of a total of 315 children who presented with newly diagnosed type 1 diabetes mellitus during a 12 year period (2006–2018) were retrospectively analyzed based on hospital records. The data were assessed by gender and age su...

hrp0089p3-p091 | Diabetes &amp; Insulin P3 | ESPE2018

Clinical and Epidemiological Features of Children with Type 1 Diabetes

Demir Şule , Cinaz Peyami , Doğer Esra , Kılınc Uğurlu Aylin , Demet Akbaş Emine , Bideci Aysun , Camurdan Orhun

Introduction: The world health organization has adopted diabetes as the most important health problem because of its increasing frequency and complications. Determination of changes in patient profile over the years due to type 1 diabetes (T1DM), the most common type of diabetes in childhood, is an important point in the follow up observation and treatment of diabetes.Aim: To determine the epidemiological and clinical characteristics of children and adol...

hrp0089p3-p092 | Diabetes &amp; Insulin P3 | ESPE2018

Predictors of Optimal Glycemic Control in Children with Diabetes Mellitus Type 1 Receiving Pump Insulin Therapy

Evsyukova Evgeniya , Kolomina Irina , Bukin Sergey , Kiseleva Elena , Latyshev Oleg , Okminyan Goar , Samsonova Lyubov

Objectives: To study predictors of target levels of glycosylated hemoglobin (HbA1c) in children with diabetes mellitus type 1 (DM1), receiving pump insulin treatment.Materials and Methods: 64 children (27 girls, 46 adolescents) with diabetes mellitus type 1 (mean age 12.8±3.5 years, disease duration 4.46±3.1 years, daily insulin dose 0.82±0.24 units) receiving pump insulin treatment for 2.46±1.43 years were studied. The res...

hrp0089p3-p093 | Diabetes &amp; Insulin P3 | ESPE2018

Symptomatic Cerebral Infarction: A Rare Complication of Diabetic Ketoacidosis

Celmeli Gamze , Parlak Mesut , Akcurin Sema , Bircan Iffet

Diabetic ketoacidosis (DKA) is accompanied by intracerebral complications from 0.3% to 1%. Cerebrovascular events account for 10% of intracerebral complications. Our aim is to present a case of symptomatic cerebral infarction as a serious complication of DKA and draw attention to the management of DKA treatment. A 3.5-years-old male patient was referred to our department with DKA for further evaluation and treatment. Before coming to our center, insulin and sodium bicarbonate ...

hrp0089p3-p094 | Diabetes &amp; Insulin P3 | ESPE2018

Our Clinical Experiences in Type 2 Diabetes

Direk Gul , Uzan Tatlı Zeynep , Nur Hepokur Merve , Gul Şiraz Ulku , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Background: Type 2 diabetes is a heterogeneous disorder characterized by the defective of insulin, which can not progressively compensate for insulin resistance, due to the influence of environmental factors on the basis of genetic susceptibility. Hyperglycemia, which starts with insulin resistance, is thought to show toxic effects (glucotoxicity) on β cells and ultimately impairs beta cell function., Although many factors play a role in etiology, obesity is the most comm...

hrp0089p3-p095 | Diabetes &amp; Insulin P3 | ESPE2018

The Relationship between Serum Levels of C-Peptide and the Age, BMI, and Insülin Doses in Reply to: Newly Diagnosed Type 1 Diabetic Children

Karaguzel Gulay , Usta Deniz , Tavaci Ayşegul , Taniş Mustafa , Beyhun Ercument

Background and aim: C-peptide is an important indicator of endogenous insulin release. Our aim was to investigate the association of serum C-peptide levels with age, BMI and insulin doses in newly diagnosed type 1 diabetic (DM1) children.Metods: The patients with newly diagnosed DM1 were enrolled the study and classified as DM1A and DM1B. Clinical and laboratory findings of all the patients were recorded. Daily insulin doses, BMI and its z score were cal...

hrp0089p3-p096 | Diabetes &amp; Insulin P3 | ESPE2018

Serum Trace Element Levels in Children Presenting with Diabetic Ketozis and Diabetic Ketoacidosis: A Longitudinal Controlled Study

Doneray Hakan , Gurbuz Kadri , Ozden Ayse , Gul Mehmet Ali , Orbak Zerrin

Objective: There have been very few studies, with contradictory results, on the serum trace elements in children and adolescents presenting with diabetic ketosis and diabetic ketoacidosis due to type-1 diabetes mellitus. The objective of this longitudinal controlled study was to determine serum trace element status including selenium (Se), zinc (Zn), copper (Cu), manganese (Mn), chrome (Cr), and cobalt (Co) in type-1 diabetic children and adolescents presenting with diabetic k...

hrp0089p3-p097 | Diabetes &amp; Insulin P3 | ESPE2018

Evaluation of Relation between Diabetic Education Levels of Type 1 DM Child/Adolescent and Parents and Metabolic Control

Kendirci Havva Nur Peltek , Karayurt Umran , Demir Emre

Introduction and aim: The education of the diabetic patients and their parents is an important phase of diabetic treatment. It is accepted in general that good control in diabetes is not possible without enough knowledge and experience about diabetes. In this study it is aimed to evaluate the relation between diabetic education levels of type 1 DM child/adolescent and parents and metabolic control.Material and method: The study included the patients and ...

hrp0089p3-p098 | Diabetes &amp; Insulin P3 | ESPE2018

A Case of Childhood Type 1 Diabetes Mellitus Who Developed Granuloma Annulare

Oztekin Aynure , Kendirci Havva Nur Peltek , Guney Guven

Introduction and aim: Granuloma Annulare (GA) is a granulomatous dermatitis of unknown etiology with numerous associations, consisting of a single or multiple small lesions (of nodular or papular shape) with annular configuration, usually localized on dorsal surfaces of the feet or hands and over other bony prominences; it is clinically painless and not pruriginous. Granuloma annulare has rarely been reported in childhood, and its association with type 1 diabetes mellitus (T1D...

hrp0089p3-p099 | Diabetes &amp; Insulin P3 | ESPE2018

Case Report: De Novo Mutation of Foxp3 Causing Mild Phenotype of Immunodysregulation, Polyendocrinopathy, Enteropathy, X-Link Syndrome

Thuy Hoang Thi Diem , Minh Nguyen Khoa Binh

Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (IPEX) is caused by mutations in the gene that encode for the transcription factor FOXP3. IPEX is a rare, often fatal disease. However, several cases present later onset, mild forms or less common clinical manifestations. We report a case who had de novo mutation of FOXP3 causing neonatal diabetes but without other features of IPEX syndrome. An 8 days old male, late preterm at 36 weeks, low birthweight 2200g...

hrp0089p3-p100 | Diabetes &amp; Insulin P3 | ESPE2018

Is There a Relationship between Immune-Mediated Type 1 Diabetes Mellitus and Congenital Rubella Infection?

Korkmaz Huseyin Anil , Ermis Cağatay

Congenital rubella infection is a transplacental infection that can cause intrauterine growth retardation, cataract, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia and severe fetal injury. It has been shown that type 1 diabetes mellitus develops in 12–20% of patients with congenital rubella infection and disorder in oral glucose tolerance test is observed in 40%. A 13-year-old male patient presented with complaints of new-onset polydipsia, urinatio...

hrp0089p3-p101 | Diabetes &amp; Insulin P3 | ESPE2018

Changes in Glycemic Control after Switching from NPH & RI to Insulin Glargine and Lispro in Children with Type 1 Diabetes Mellitus (T1DM)

Kim Hyeon-A , Moon Jung-Eun , Lee Soo-Jeong , Lee Gi-Min , Ko Cheol-Woo

Background and objective: It has been reported that glycemic control gets better in children with T1DM on insulin glargine and lispro when compard to patients on NPH and RI. This study was conducted to see the changes of glycemic control after switching from insulin glargine and lispro (GLAR/LIS) to NPH and RI (NPH/RI) in Korean children with T1DM.Materials and methods: We studied 14 patients who were diagnosed with T1DM in Kyungpook National Children&#1...

hrp0089p3-p102 | Diabetes &amp; Insulin P3 | ESPE2018

When Type Mody Ii Diabetes Simulates Type I Diabetes

Viseras Irene Pilar Fernandez , Mata Maria Angeles Santos , Barea Isabel Torres , Gonzalez Luis Castano

Introduction: Mutations of the GKN gene are the most common cause of Mody diabetes. MODY II typically results in mildly elevated fasting blood sugar, without noticeable diabetes, maintaining good metabolic control without treatment.Clinical case: A 4.5 years old female infant, was referred due to presenting polyuria, polydipsia and fasting hyperglycemia of 126–130 mg/dl and 2 hours post-intake blood glucose level of 150–220 mg/dl. She was born ...

hrp0089p3-p103 | Diabetes &amp; Insulin P3 | ESPE2018

Epidemiological Study and Analysis of Type 1 Diabetes Comparing Patients with and Without Ketoacidosis in the Last 5 Years

Viseras Irene Pilar Fernandez , Mata Maria Angeles Santos , Delgado Silvia Ponce , Perez Celia Morales , Lopez Francisco Jose Macias

Type 1 diabetes (T1DM) in childhood is a highly prevalent disease, with incidence oscillating around 17.6/100000. However, incidence is higher in some communities (25.5/100,000), as it is in the case that concerns us. Diabetic ketoacidosis (DKA) is a complication usually recorded in 25–40% of cases but has been as high as 55% in studies of children under 5 years old. (T1DM) is an associated autoimmune disease to other precursor autoimmune pathologies.<p class="abstext...

hrp0089p3-p104 | Diabetes &amp; Insulin P3 | ESPE2018

The Frequency of Diabetic Ketoacidosis Hospitalization in Siberian Children and Adolescent

Osokina Irina

Introduction: Diabetic ketoacidosis is a frequent reason for hospital admission of children with newly diagnosed diabetes and the most frequent cause for hospitalization of children with poorly controlled diabetes.Aim: To evaluate the frequency of diabetic ketoacidosis (DKA) hospitalization for pediatric patients and resources for its decrease.Methods: Subjects included children <19 years who hospitalized with DKA in the pediat...

hrp0089p3-p105 | Diabetes &amp; Insulin P3 | ESPE2018

Monogenic Diabetes Cause by Mutation of the Gene HNF–1A

Narvaez Juan Manuel , Leon Maria Clemente , Oriol Josep

Introduction: The MODY diabetes (Maturity Onset Diabetes of the Young) belongs to monogenic alterations group, the mutation of the gene HNF-1α is the most common and present an autosomal dominant inheritance that causes dysfunction of the Beta pancreatic cell and alteration in the reabsorption of glucose to renal level, with age of variable presentations, it often leads to a misdiagnosis as type 1 diabetes mellitus.Description of the clinical case: ...

hrp0089p3-p106 | Diabetes &amp; Insulin P3 | ESPE2018

Reversibility of Early Acute Diabetic Neuropathy (DN) in Adolescents with Type 1 Diabetes Mellitus (T1D)

Louraki Maria , Kokotis Panagiotis , Katsalouli Marina , Kallinikou Dimitra , Kanaka-Gantenbein Christina , Karavanaki Kyriaki

Introduction: Diabetic neuropathy (DN) is a common complication of type 1 diabetes mellitus (T1D) with significant morbidity in adulthood. The association between DN with long term poor metabolic control is well established. However, acute painful DN may present early in the course of the disease and may be reversible.Case presentation: A female adolescent, aged 12 years, with a T1D duration of 9 months, presented with acute metabolic derrangement (HbA1c...

hrp0089p3-p107 | Diabetes &amp; Insulin P3 | ESPE2018

The Value of Continuous Hemodiafiltration in Rescuing Children with Severe Diabetic Ketoacidosis

Chen Lin QI , Zhang Dan Dan , Wu Hai Ying , Chen Ting , Chen Xiu Li , Wang Feng Yun , Xie Rong Rong

Objective: To explore the value of continuous hemodiafiltration in rescuing children with severe diabetic ketoacidosis.Method: Two children with severe diabetic ketoacidosis were studied in regard to clinical manifestation, laboratory examination and treatment and of the relevant literature was reviewed.Result: Case 1 was a girl of 13 years 5 months old, who was diagnosed as ‘Type 1 diabetes mellitus, Diabetic ketoacidosis and...

hrp0089p3-p108 | Diabetes &amp; Insulin P3 | ESPE2018

Psychosocial Risks, Comorbidities and Health Events During the Follow-up of Children and Adolescents with Type 1 Diabetes

Temboury Ma Carmen , Villamor Raquel , Hernandez Ma Belen , Lapena Sara , Lopez Cristina

Background: Psychosocial factors and health events are important for patients with chronic diseases such type 1 diabetes (TD1).Objective and hypotheses: The aim was to explore the psychosocial factors, health events and comorbidity found at diagnosis and during the follow up of children and adolescents with type 1 diabetes. Also to analyze the association between socioeconomic status and glycaemic control.Method: Medical charts of ...

hrp0089p3-p109 | Diabetes &amp; Insulin P3 | ESPE2018

Clinical Profile and Outcome of Diabetic Ketoacidosis in a Tertiary Care Teaching Hospital of a Developing Country

Chawla Meghna , Deshpande Tushar , Behera MK

Objectives: Diabetic Ketoacidosis (DKA) is a dreaded complication and due to a paucity of studies on Paediatric DKA from India, we studied its clinical profile and outcome over the last 03 years.Methods: A retrospective chart review was used to obtain demographics, clinical presentation and various laboratory parameters on presentation of DKA in children less than 12 years of age.Results: See Tables 1–3.<table boarder="1" ...

hrp0089p3-p110 | Diabetes &amp; Insulin P3 | ESPE2018

Diabetes Mellitus, Autoimmune Hemolytic Anemia, Hepatosplenomegaly and Lymphadenopathy: A Rare Association in Chinese Children

Zhang Miaoying , Li Xiaojing , Xi Li , Zhao Zhuhui , Cheng Ruoqian , Wu Bingbing , Luo Feihong

Objectives: To report a case of concomitance of diabetes mellitus, autoimmune hemolytic anemia, hepatosplenomegaly and lymphadenopathy in a 7-year girl.Methods: Retrospective review of medical records of a patient with multiple autoimmune diseases followed at the Departments of Endocrinology and Metabolism, Children’s Hospital of Fudan University. This rare case was undergoing whole exome sequencing.Results: This girl 2 year w...

hrp0089p3-p111 | Diabetes &amp; Insulin P3 | ESPE2018

Type 1 Diabetes and Central Precocious Puberty a Rare Association

Bessahraoui Mimouna , Oussaleh Nassima , Azzouz Sidi Mohamed , Rezak Radia

Introduction: In girls, precocious puberty is defined as the sign of secondary sexual characteristics occurring before the age of 8 years in Caucasian girls. Type 1 diabetes (T1D) is a rare association with precocious puberty. We discuss through this case, the involvement of type 1 diabetes mellitus in the onset of early puberty from a review of the literature.Observation: We report the case of precocious puberty in a 6-year-old girl followed for T1D sin...

hrp0089p3-p112 | Diabetes &amp; Insulin P3 | ESPE2018

Diabetic Ketoacidosis among Egyptian Children with Type 1 Diabetes: 3-Years Study

Karem Mona , Alsabahy Khalid , Elfiky Ahmed , Meshref Ahmed , Akl Heba

Introduction: Diabetic Ketoacidosis (DKA) is one of the acute complications of type 1 diabetes. It is a life-threatening condition that varies in severity and prognosis from patient to another. In Egypt, there is no available data about the socio-demographic characteristics as well as the DKA severity determinants among childrenObjective: 1. To identify demographic, clinical and laboratory variables of pediatric patients diagnosed with DKA at Suez Canal ...

hrp0089p3-p113 | Diabetes &amp; Insulin P3 | ESPE2018

Fructosamine Level in Type 1 Diabetes Mellitus Children Performing Ramadhan Fasting

Faizi Muhammad , Rochmah Nur

Background: Ramadan fasting may influence metabolic control in Type 1 Diabetes Mellitus. Fructosamine is an accurate metabolic control in a short-term period. Comparison of fructosamine between intensive and conventional insulin regimen in T1DM children has not been widely studied.Objective: To compare fructosamine level between intensive and conventional insulin regimens during Ramadan Fasting in T1DM.Methods: Observational analyt...

hrp0089p3-p114 | Diabetes &amp; Insulin P3 | ESPE2018

Metformin Therapy Ina Lean Adolescent Girl with Prediabetes Dysglycemia Treated: Good Response

AlAaraj Nada , Hermi Amene , Hamed Noor , Ahmed Shaymaa , Soliman Ashraf

Background: Metformin (dimethylbiguanide) is the most widely prescribed treatment for children with T2DM. Long term controlled studies are still required to assess its effect on prediabetes dysglycemia in childrenCase presentation: A 13-year-old lean adolescent girl presented to PEC with a day history of difficult breathing associated with dry cough. No history of fever, abdominal pain, vomiting or change in bowel motion. She had a 10 months’ histor...

hrp0089p3-p115 | Diabetes &amp; Insulin P3 | ESPE2018

Association between Thyroid Stimulating Hormone and Hemoglobine A1c in Type 1 Diabetes Mellitus Children

Rochmah Nur , Faizi Muhammad

Background: Type 1 Diabetes Mellitus children are at risk to suffer from thyroid dysfunction. The association between thyroid stimulating hormone and hemoglobin A1c is still controversy.Objective: To determine the association between thyroid stimulating hormone and hemoglobin A1c in type 1 Diabetes Mellitus children.Methods: We conducted a cross sectional study from January - June 2017 in pediatric endocrine outpatient clinic dr So...

hrp0089p3-p116 | Diabetes &amp; Insulin P3 | ESPE2018

Monogenic Diabetes in 2 Years and 4 Months Old Girl: Is it DEND?

Rochmah Nur , Faizi Muhammad , Purwana Arie

Background: Monogenic forms of diabetes are still rare and not well understood. Their prevalence accounting for 1–4% of pediatric diabetes cases. Several genes encoding proteins important to β-cell function or regulation have been identified that lead to monogenic diabetes. However, awareness of these conditions may be lacking, and screening for them genetically is not routinely undertaken due to lack facility.Objective: To report a case diagno...

hrp0089p3-p117 | Diabetes &amp; Insulin P3 | ESPE2018

Compliance for Monitoring of Glycemic Control in Children with Type 1 Diabetes

Latyshev Oleg , Simakova Maria , Samsonova Lyubov , Okminyan Goar , Kiseleva Elena , Fialtov Alexander , Kasatkina Elvira

Topic: Compliance for monitoring of glycemic control in children with type 1 diabetes.Background and Aims: To estimate attachment of children with type 1 diabetes to self-control of blood glucose with help of automatically data processing system of glycemic control.Method: We have checked 54 patients with first type diabetes at the age 14±3, 4 years old (32 males, 22 females), divided into two age groups: from 0 to 14, and 15-...

hrp0089p3-p118 | Diabetes &amp; Insulin P3 | ESPE2018

Ketogenic Diet in a Child with Diabetes and Global Developmental Delay

Win Myat , Rajalingam Usha , Goonetilleke Rajiv

Effective management of Type 1 diabetes can be challenging. We would like to discuss the management of a 7 year old boy with Type 1 Diabetes, Lissencephaly and global severe developmental delay with medically refractory epilepsy who was introduced to and managed on a Ketogenic diet to try and improve his seizure control. He is non mobile and non-verbal and purely gastrostomy fed. He has diagnoses including. Lissencephaly and band heterotopia, absent corpus callosum, microcepha...

hrp0089p3-p119 | Diabetes &amp; Insulin P3 | ESPE2018

A Rare Cause of Severe Anemia in a Patient with Type 1 Diabetes

Piekarski Robert , Bury Anna , Beń-Skowronek Iwona

Introduction: Anemia in children is still quite common, sometimes it is a secondary symptom of another rare disorder. Rendu-Osler-Weber disease, a genetically determined haemorrhagic diathesis, is characterized by the occurrence of vascular malformations leading to bleeding from the nose, skin and mucous membranes and to various internal organs. Diagnosis facilitates the occurrence of the disease in relatives of the first degree, however, due to the progressive nature of vascu...

hrp0089p3-p120 | Diabetes &amp; Insulin P3 | ESPE2018

Oral Gliclazide (A Sulfonylurea) Monotherapy is Effective and Safe in the Management of T2DM in Children: A Case Report

Ahmed Shayma , Soliman Ashraf , Alaaraj Nada , Hamad Noor

Introduction: Most of the oral medications available for treating type 2 diabetes (T2DM) have not been studied in children. T2DM in pediatric patients is usually treated with metformin and insulin. The use of other oral antidiabetic drugs is not clearly delineated in T2DM in children although potentially useful.Case report: A 13 year-old girl, presented with polyuria, polydipsia and weight loss (5 kg) for 2 weeks before presentation. Her Weight=65.7 kg, ...

hrp0089p3-p121 | Diabetes &amp; Insulin P3 | ESPE2018

Pediatric Stroke as the Presenting Symptom of New Onset Diabetes without DKA

Bharill Sonum , Constantacos Cathrine

Introduction: Neurologic symptoms, such as cerebral edema, stroke, and extrapontine myelinolysis, are rare in pediatric patients with type 1 diabetes mellitus (T1DM) in the absence of severe diabetic ketoacidosis (DKA) or chronically poor glycemic control. Ischemic or hemorrhagic stroke may account for 10% of intracerebral complications of DKA. DKA increases the risk for neurovascular compromise by several proposed mechanisms, including dehydration, hyperosmolarity, tissue hyp...

hrp0089p3-p122 | Diabetes &amp; Insulin P3 | ESPE2018

Challenges in Educating New Onset Type 1 Diabetes Mellitus Patients: Can the Use of a Tablet be the Answer?

Aisenberg Javier , Rosini Lynda , Haugh Jeanette , Mathus Susan , De Vito Michele , Brennan Ingrid , Ghanny Steven

Background: Educating patients and families on the management of Type 1 Diabetes Mellitus (DM) has always been a challenge. Some endocrinologists educate patients and families with new onset Type 1 DM in the inpatient setting, while others have tried to do this process as an outpatient given the changes in the limits of inpatient coverage. Given the challenges in the education process, we must find new and innovative ways to educate patients and families efficiently in order t...

hrp0089p3-p123 | Diabetes &amp; Insulin P3 | ESPE2018

AID-GM System (Advanced Intelligent Distant – Glucose Monitoring) to Monitor Health Status and Metabolic Control of Young People with Type 1 Diabetes

Calcaterra Valeria , Sacchi Lucia , Salvi Elisa , Larizza Daniela , Made Alexandra , Schiano Luca Maria , Montalbano Chiara , Regalbuto Corrado , Bellazzi Riccardo , Larizza Cristiana

Aim of the study: In type 1 diabetes, it is well recognized that collecting additional information about diet, physical activity, health status, stress and any patients’ everyday behavior, is crucial to evaluate accurately metabolic control and therapeutic prescription adherence. The aim of this study is to test AID-GM (Advanced Intelligent Distant – Glucose Monitoring) a web-based platform, able of collecting automatically patient generated health data (PHGD) coming...

hrp0089p3-p124 | Diabetes &amp; Insulin P3 | ESPE2018

Continuous Glucose Monitoring Results of Our Cases with MODY Type 2 Diabetes

Tatlı Zeynep Uzan , Direk Gul , Hepokur Mervenur , Hatipoğlu Nihal , Akın Leyla , Kendirci Mustafa , Kurtoglu Selim

Introduction: The most common type of diabetes in childhood is type-1 diabetes. The group of diabetes called MODY (maturity-onset diabetes of the young) is rarer. Mutations that occur in glucokinase gene cause disruption in the perception of the resultant glucose level and, consequently, impaired insulin release, leading to the development of MODY-2. In this case, resulting hyperglycemia is usually at a mild, non-progressive level and does not require insulin therapy. For this...

hrp0089p3-p399 | Diabetes &amp; Insulin P3 | ESPE2018

Family Investigation and Clinical Phenotype Analysis of Type A Insulin Resistance Syndrome

Chen Yonghua , Chen Hong , Fang Yanlan , Wang Chunlin , Zhu Jianfang , Liang Li

Objective To study a large Chinese family with Type A Insulin Resistance Syndrome (TAIRS) and the members’ clinical phenotypes. Explore their genotype-phenotype relationship between environmental factors and hereditary features. Methods 19 members of the family were investigated for their past history, dietary habits and living habits. PCR and Sanger sequencing were applied to detect mutations of the INSR gene among 6 core members from the Pedigree. Besides, fasting blood...

hrp0089p3-p403 | Diabetes &amp; Insulin P3 | ESPE2018

Epidemiology, Demographic Criteria and Risk Factors in Type 1 DM Egyptian Children; A Single Center Study

Badawi Nora , Shaalan Yomna

Introduction and Objectives: Type 1 DM is a chronic metabolic disease. Its incidence is rising worldwide. We studied demographic criteria, risk factors and epidemiology of children with type 1 DM attending our diabetes control clinic.Methods: This cross sectional study was conducted over 3214 children between 1–18 years who are diagnosed with type 1 diabetes and following up in DEMPU clinic, Cairo university children’s hospital. Between April 2...

hrp0089p3-p407 | Diabetes &amp; Insulin P3 | ESPE2018

Degludec Versus Glargine in Pediatric and Adolescent Patients with Type 1 Diabetes

Gil-Poch Estela , Javier Arroyo-Diez Francisco , Beato-Vibora Pilar I

Introduction: To optimal glycemic control without hypoglycemia must be the aim of insulin treatment for all patients with type 1 diabetes (T1DM). Despite the advantages of the basal-bolus insulin regimens with MDI, hypoglycemia presents a major barrier in achieving desirable blood glucose levels. Degludec is a new basal insulin analog with longer half-life and lower variability.Objetive: To investigate the differences between long-acting insulins glargin...

hrp0089p3-p416 | Diabetes &amp; Insulin P3 | ESPE2018

A Rare and Unexpected Cause of Diabetes in Childhood

Makaya Taffy , Basu Supriyo , Ali Aishatu

Background: Pancreatogenic diabetes is rare in children. The prevalence is 5–10% of all cases of diabetes in the developed world. The underlying pathophysiology is destruction of islet cells by pancreatic inflammation.Case: A 15-year old previously healthy boy presented with polyuria, polydipsia, abdominal pain and loss of weight (LOW) over several weeks. Family history revealed a three-generational history of diabetes including reported type-1 (T1D...

hrp0089p3-p417 | Diabetes &amp; Insulin P3 | ESPE2018

Study of Children with Type 1 Diabetes Mellitus of Long Duration Attending Alexandria University Children’S Hospital

Fawzy Dina , Elsayed Shaymaa , Abd El-Moneim Mahmoud

Background: Type 1 diabetes mellitus (T1DM) is a complex metabolic disorder typically diagnosed in childhood and characterized by insufficient insulin production. Diabetic complications are still a major concern as they constitute the main cause of morbidity and mortality in diabetic patients despite the advances in T1DM treatment. Long-term complications of diabetes include retinopathy with potential loss of vision; nephropathy leading to renal failure; peripheral neuropathy ...

hrp0089p3-p419 | Diabetes &amp; Insulin P3 | ESPE2018

Abstract Unavailable....