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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

Poster Presentations

Diabetes & Insulin P2

hrp0089p2-p060 | Diabetes & Insulin P2 | ESPE2018

Incidence of Childhood Type 1 and Type 2 Diabetes Mellitus in Qatar between 2012–2016

Alyafei Fawziya , Soliman Ashraf , Alkhalaf Fawziya , Waseef Reem , Abdulkayoum Anas , Sayed Ahmed , Eldarsy Nagwa , Sabt Aml

Introduction: The overall age-adjusted incidence of type 1 diabetes (T1DM) varied from 0.1/100,000 per year in China and Venezuela to 36.8/100,000 per year in Sardinia and 36.5/100,000 per year in Finland. This represents a 350-fold variation in the incidence among the 100 populations Worldwide. In the early 1990s, T2DM it was representing about 3 percent only of pediatric diabetes in the United States, but by 2003, T2DM reached about 20 percent of pediatric diabetes.<p cl...

hrp0089p2-p061 | Diabetes &amp; Insulin P2 | ESPE2018

The Prevalence of Double Diabetes in Children and Adolescents in Qatar

Soliman Ashraf , Alyafei Fawzia , Wasfy Reem , Aldarsy Nagwa

The incidence of both type 1 (T1DM) and type 2 diabetes (T2DM) has shown a rise in Qatar in parallel with a notable increase in the incidence of a new expression of the disease in children and adolescents, with the characteristics of a mixture of the two types of diabetes and referred to as ’double diabetes’ (DD). Insulin resistance and obesity, together with the presence of markers of pancreatic autoimmunity - namely, autoantibodies to islet cell antigens - typicall...

hrp0089p2-p062 | Diabetes &amp; Insulin P2 | ESPE2018

Prevalence of Diabetes Type 1 and Type 2 in Children and Adults in Kazakhstan in 2016

Nurbekova Akmaral , Balmuchanova Aigul , Ten Svetlana , Bhangoo Amrit

Introduction: The prevalence of diabetes for all age-groups worldwide was estimated to be 28/1000 in 2000 and 44/1000 in 2030 (1). In the SEARCH study in a population of 3,458,974 US youth less than 20 yrs the prevalence of T1D was 1.93/1,000 and type 2 diabetes 0.24/1,000 (2).Methods: We reviewed data on already diagnosed patients with type 1 and type 2 diabetes from official statistical collection of Ministry of Health of Kazakhstan in 2016 (3).<p ...

hrp0089p2-p063 | Diabetes &amp; Insulin P2 | ESPE2018

Detection of the Pathogenic Genes in the Diagnosis and Treatment of Hyperglycemia Infants and Children

Zhao Zhuhui , Cheng Ruoqian , Xi Li , Li Xiaojing , Zhang Miaoying , Pei Zhou , Sun Chengjun

Objectives: To explore the clinical value of common pathogenic gene detection in the diagnosis and treatment in hyperglycemia infants and children.Subjects and Methods: Subjects were in-patients with hyperglycemia, age of onset before 1 year-old, or insulin antibody negative and with family history of diabetes. Gene sequencing for ABCC8, KCNJ11, INS and GCK were performed and potential mutations were analyzed. The pati...

hrp0089p2-p064 | Diabetes &amp; Insulin P2 | ESPE2018

Early Diagnosis of Diabetes Type 2 in Children with Progeria Syndromes

Bald Martin , Timmermann Kirsten , Wadien Tanja , Krahling Eva , Holder Martin

Progeria syndromes are rare in children and include several diseases which lead to premature ageing already in children. Therefore, the pediatrician may be confronted with diseases which are normally seen only in persons with advanced age. We report about two children with progeria, in whom diabetes type 2 become manifest early and with a fulminant course in one patient. The first boy was known with Cockayne syndrome, which belongs to the progeria syndromes. He suffered from l...

hrp0089p2-p065 | Diabetes &amp; Insulin P2 | ESPE2018

Transient Neonatal Diabetes Mellitus due to not Described Mutation in ABCC8 Gene with Different Behaviour in Affected Family Members

Angeles Santos Mata Maria , Pilar Fernandez Viseras Irene , Torres Barea Isabel , Castano Gonzalez Luis

Neonatal diabetes (ND), classified as either permanent (PND) or transient (TND), occurs in 1/200,000 live births. In 50% cases of TND, remission presents within the first year of life, only to relapse later before puberty in 50% of cases. The most frequent cause is mutation of the 6q24 gene accompanied by mutations in heterozygosis of ABCC8 gene. 80% of mutations in this gene are in novo, due to autosomal recessive inheritance. Such cases respond to treatment with sulfonylurea...

hrp0089p2-p066 | Diabetes &amp; Insulin P2 | ESPE2018

Prothrombin Gene 20210A Mutation Heterozygosity and MTHFR Gene C677T Mutation Homozygosity Detected in a Male Toddler Experiencing Femoral Venous Thrombosis During Diabetic Ketoacidosis

Kleisarchaki Angeliki N , Giza Styliani , Nikolaidou Olga , Mouzaki Konstantina , Kotanidou Eleni P , Litou Eleni , Rengina Tsinopoulou Vasiliki , Papadakis Emmanouil , Galli-Tsinopoulou Assimina

Introduction: Diabetic ketoacidosis (DKA) as an inflammatory state combined with the disruption of the normal coagulation cascade can lead patients to an increased risk of thrombosis. Especially, patients that are genetically susceptible to thrombosis could develop deep venous thrombosis (DVT) due to inflammation, dehydration, and hyperviscosity secondarily to DKA. It is noteworthy that children with DKA who underwent central venous catheter placement could develop DVT, especi...

hrp0089p2-p067 | Diabetes &amp; Insulin P2 | ESPE2018

Frequency of Occurrence of MODY in the Population of Diabetic Patients in St. Petersburg

Turkunova Mariia , Bashnina Elena , Berseneva Olga , Glotov Oleg , Glotov Andrei , Serebryakova Elena

The purpose of this study is to determine the frequency of occurrence and molecular-genetic characteristics of MODY in patients with diabetes mellitus aged 1 to 18 years, residents of St. Petersburg.Materials and methods: In St. Petersburg in 2017, there were 1620 patients with diabetes mellitus under the age of 18 years. 54 of them had evidence of hereditary variants of diabetes with chronic hyperglycemia at normal c-peptide indices for 2 years after th...

hrp0089p2-p068 | Diabetes &amp; Insulin P2 | ESPE2018

Acute Painful Diabetic Neuropathy (Apdn) in a Boy with Type 1 Diabetes

Muz Nataliia , Pakhomova Viktoriia , Sprinchuk Nataliia

A 15y10m boy was presented to our hospital (in March 2017) with the complaints of acute, severe, continuous, burning pain affecting soles and both legs, insomnia, loss of body weight and appetite. He described his pain as stabbing and burning. He also perceived contact with bed clothing, socks, shoes or floor as causing extreme discomfort. He could barely move out of bed. He had no symptoms in hands or any other neurological complaints. An. Morbi: type 1 diabetes was diagnosed...

hrp0089p2-p069 | Diabetes &amp; Insulin P2 | ESPE2018

Features of Japanese Patients with Early-Onset, Mody-Like Diabetes without Mutations in the Major Mody Genes

Yorifuji Tohru , Kawakita Rie , Higuchi Shinji , Yamada Yuki , Ohyachi Maki , Matsumura Kana

We perfomed mutational analyses of the major MODY genes (HNF1A, HNF4A, HNF1B, GCK) on 263 Japanese patients with early-onset, nonobese, MODY-like diabetes mellitus referred to Osaka City General Hospital for diagnosis. Mutations were identified in 103 (35.9%) patients; 57 mutations in GCK; 29, HNF1A; 7, HNF4A; and 10, HNF1B. Compared with these mutation-positive patients, 160 mutation-negative patients were significantly older (P=0.003), and had high...

hrp0089p2-p070 | Diabetes &amp; Insulin P2 | ESPE2018

Frequency and Etiologic Spectrum of Monogenic Diabetes in Pediatric Diabetes in a Single Academic Center

Choi Jin-Ho , Seo Go Hun , Oh Arum , Kim Gu-Hwan , Yoo Han-Wook

Purpose: Type 1 diabetes mellitus (DM) is the most common cause of diabetes in children and adolescents. Prevalence of monogenic DM is estimated for about 1%–5% of all patients with DM. Overlapping clinical features of various forms of diabetes make differential diagnosis challenging. This study was performed to investigate frequency and genetic etiologies of monogenic diabetes in a single academic center.Methods: This study included 466 consecutive...

hrp0089p2-p071 | Diabetes &amp; Insulin P2 | ESPE2018

Clinical Details, Molecular Genetic Analysisand Clinical Pheonotype Correlation of 14 Patients with Neonatal Diabetes from The South India – A Single Centre Experience

Nagesh V Sri , Hattersley Andrew , Ellard Sian , Sethi Bipin , Franco Elisa De , Flanagan Sarah , Houghton Jayne , Venkateshwarlu M , Parekh Harsh , Dukle Vaibhav , Kelwade Jayant , Naseem Altaf , Kanithi Ravishankar , Nalli Ravi Kumar

Background: Neonatal diabetes mellitus (NDM) is a relatively rare form of monogenic diabetes and usually presents in the first 6–9 months of life. In this study, our objective was to report the clinical details, perform a detailed genetic analysis and acquire a clinical–phenotype correlation of our cohort.Materials and methods: NDM patients referred to SN Endocrine centre between period of Nov 2014 to April 2017 and patients under follow-up wit...

hrp0089p2-p072 | Diabetes &amp; Insulin P2 | ESPE2018

Syndromic Patients with Negative Islet Autoantibodies should be Tested for Mongenic Diabetes: Lessons from Patient with Trmt10a Mutation

Siklar Zeynep , Colclough Kevin , Patel Kashyap A , Cetin Tuğba , Berberoğlu Merih

Aim: Glucose metabolism can affect by several genes, and some of them represent distictive clinical and laboratory features. tRNA methyltransferase 10 homologue A (TRMT10A) gene is a tRNA methyl transferase, and localised to the nucleolus, where tRNA modifications occur. Very recently, a novel syndrome of abnormal glucose homeostasis or nonautoimmune diabetes associated with microcephaly, epilepsy, intellectual disability, failure to thrive, delayed puberty caused by ...

hrp0089p2-p073 | Diabetes &amp; Insulin P2 | ESPE2018

A Novel Mutation in Phka2: Idiopathic Ketotic Hypoglycaemia May Represent Mild Gsdixa

Flejsborg Anne Benner , Brusgaard Klaus , Pedersen Carsten , Frederiksen Anja L , Christesen Henrik T

Background: Idiopathic ketotic hypoglycaemia (IKH) is an exclusion diagnosis and the most common cause of hypoglycaemia in childhood. Glycogen Storage disease (GSD) type IX comprises one quarter of all GSD’s. GSDIXa, encoded by PHKA2, is the most frequent subtype.Objective: To investigate whether IKH may be undiagnosed GSDIXa.Methods: Hospital file review and next generation sequence 29 gene GSD-panel.<p class="ab...

hrp0089p2-p074 | Diabetes &amp; Insulin P2 | ESPE2018

The Application of Next Generation Sequencing Mody Gene Panel in Greek Patients

Tatsi Elizabeth , Smirnaki Penelopi , Triantafilou Panagiota , Tsiroukidou Kyriaki , Kotsa Kalliopi , Lambadiari Vaia , Chrousos George , Kanaka-Gantenbein Christina , Sertedaki Amalia

Background: Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD). It is characterized by early onset, autosomal dominant inheritance and a defect in β cell insulin secretion. To date 14 different MODY subtypes have been reported each one with a distinct genetic aetiology. However four are the most common subtypes, namely MODY 1 (HNF4A), MODY2 (GCK), MODY3 (HNF1A), MODY...

hrp0089p2-p075 | Diabetes &amp; Insulin P2 | ESPE2018

Type 5 Monogenic Diabetes: Reportof 7 Cases

Eduard Mogas , Rosa Pacheco , Diego Yeste , Ariadna Campos , Luis Castano , Maria Clemente

Introduction: Type 5 monogenic diabetes is an autosomal dominant disease due to a mutation in HNF1beta gene. This gene is expressed predominantly in kidney and pancreas, thus clinical manifestations are characterised by renal abnormalities and diabetes.Objectives: To review the clinical characteristics of patients who were diagnosed with type 5 monogenic diabetes in the Pediatric Endocrinology Unit of a tertiary referral hospital.<p class="a...

hrp0089p2-p076 | Diabetes &amp; Insulin P2 | ESPE2018

Novel Gata6-Mutation in a Boy with Neonatal Diabetes and Diaphragmatic Hernia

Gaisl Odile Christin , Konrad Daniel , Steindl Katharina , Lang-Muritano Mariarosaria

Background: Onset of diabetes in the neonatal period with additional malformations e.g. congenital heart defects should always be suspicious for an underlying genetic disorder. For example, GATA6-mutations were identified in children with congenital heart defects and neonatal diabetes. The latter may be due to pancreas agenesis. Herein we present a novel GATA6-mutation in a boy with transient neonatal diabetes, diaphragmatic hernia, congenital heart defect and early onset scol...

hrp0089p2-p077 | Diabetes &amp; Insulin P2 | ESPE2018

Clinical and Genetic Characterizations of Maturity Onset Diabetes of the Young: Single Center Results

Guven Ayla , Yıldırımoglu Canan

Background: Maturity onset diabetes of the young (MODY) is a group of monogenic disorders classically presenting in adolescence or young adults before the age of 25 years. MODY is a rare cause of diabetes.Methods: In this study, a panel of 23 MODY genes was screened. The Human Gene Mutation Database (HGMD), Clinvar, dbSNP and Exac database used for known or new variants causes MODY. Classification of variants performed according to ACMG 2015 Guidelines. ...

hrp0089p2-p078 | Diabetes &amp; Insulin P2 | ESPE2018

Protein and Fat Effects on Post - Prandial Glucose Responses among Egyptian Children and Adolescents with Type 1 Diabetes Mellitus

Arafa Noha , Hafez Mona , Anwar Ghada , Abdou Marise , Ibrahim Rania

Background: In the light of emerging recent researches and the use of continuous glucose monitoring it was shown that other nutritional properties of food, including fat, protein, and glycemic index (GI), can significantly affect postprandial glucose excursions. These findings highlight the need for alternative mealtime insulin dosing algorithms and have important implications for nutrition education and counseling in patients with diabetes.Objective and...

hrp0089p2-p079 | Diabetes &amp; Insulin P2 | ESPE2018

Amino Acids Plasma Profile in Children with Type 1 Diabetes

Dura-Trave Teodoro , Cortes-Castell Ernesto , Moya-Benavent Manuel , Chueca-Guindulain Maria Jesus , Berrade-Zubiri Sara , Nogueira-Lopez Javier

Background: Insulin deficiency inhibits protein synthesis and stimulates protein degradation, and then amino acids metabolism could be altered in diabetes mellitus.Objective: The aim of this study is to analyze amino acid plasma profile in a group of children with type 1 diabetes, and to evaluate its potential application as markers of metabolic control of the disease.Subjects/Methods: A clinical assessment and metabolic study (ami...

hrp0089p2-p080 | Diabetes &amp; Insulin P2 | ESPE2018

Betatrophin as a New Biomarker of Type 1 Diabetes Mellitus in Paediatrics

Ara Laura Bosch i , Villalba Adria , Murillo Marta , Fonolleda Mireia , Vazquez Federico , Rodriguez-Fernandez Silvia , Vives-Pi Marta , Bel Joan

Introduction: Type 1 Diabetes Mellitus (DM1) is an autoimmune disease resulting from the destruction of pancreatic β cells. After the diagnosis, up to 80% of patients spontaneously experience partial remission (PR) for months. New biomarkers are being studied, such as the betatrophin protein (ANGPTL8) of unknown function, but which could be involved in the evolution of DM1, in this phase of RP and even used as a therapeutic target.Methods: Observati...

hrp0089p2-p081 | Diabetes &amp; Insulin P2 | ESPE2018

Vitamin D Status among Children and Adolescent with T1DM

Khudhur Mohamed Firas , Jasim Waleed

Background: Vitamin D deficiency is currently a topic of intense interest, and is widely prevalent. Low vitamin D levels have been reported in many immune disorders as type 1 diabetes Mellitus (T1DM). AIM of this study is to assess the vitamin D status in T1DM children and adolescent in Karbala.Patients and methods: A case control study, a total of 171 subject, consisted of two groups; diabetic patients 121 cases (48 male and 73 female), aged 5–16 y...

hrp0089p2-p082 | Diabetes &amp; Insulin P2 | ESPE2018

IGF-1 Relationship with Growth Velocity in Precocious Puberty with GnRHa Treatment

Sahin Nursel Muratoglu , Cetinkaya Semra , Erdeve Senay Savas , Aycan Zehra

Background: Although it is reported that central precocious puberty (CPP) GnRH analogue (GnRHa) treatment decreases the growth velocity, its relation with IGF-1 is controversial. We aimed to investigate the effects of GnRHa treatment on IGF-1 level and the relationship between IGF-1 level and growth velocity (GV) in our study.Method: Forty-four girls with CPP, who started breast development before the age of 8 years, were enrolled in the study. IGF-1 lev...

hrp0089p2-p083 | Diabetes &amp; Insulin P2 | ESPE2018

Relation between Hypomagnesemia and Increased Level of HbA1c in Patients with Diabetes Mellitus

Kang Seokjin , Kim Heung Sik

Background: Hypomagnesemia is a frequent condition in patients with diabetes mellitus (DM). It could influence metabolic control in patients with DM. Relevant studies concern mainly adults and there are few data from the pediatric population. The aim of the present study was to evaluate magnesium levels and examine their possible association with glycemic control in pediatric patients with diabetes mellitus.Methods: In all, 36 patients with DM (type 1, 3...

hrp0089p2-p084 | Diabetes &amp; Insulin P2 | ESPE2018

PID1 Alters Antilipolytic Action of Insulin and Increases Lipolysis via Inhibited the Activation of AKT/PKA Pathway

Yin Chun , Xiao Yan

Objective: The aim was to investigate the mechanism for impaired control of lipolysis in obesity by investigating the effect of PID1 on insulin-induced activation of AKT/PKA/HSL pathway and lipolysis.Methods: First, CIDEC expression was detected in adipose tissue and blood insulin and glycerol levels were measured in high-fat diet-induced obese rats. Next, we examined the effect of different concentrations of insulin on lipolysis and AKT/PKA/HSL pathway ...

hrp0089p2-p085 | Diabetes &amp; Insulin P2 | ESPE2018

The Efficacy of Tri-ponderal Mass Index and Body Mass Index in Estimating Insulin Resistance, Hyperlipidemia and Impaired Liver Enzymes During Childhood and Adolescents

Akcan Nese , Obyed Moaaz , Salem Jana , Bundak Ruveyde

Body mass index (BMI) is used to diagnose obesity in children and adolescents. Recently, the tri-ponderal mass index (TMI) has been reported to be nearly stable throughout adolescence and estimate body fat levels more accurately than BMI especially in adolescents. Aim: To compare the efficacy of TMI and BMI in forecasting of insulin resistance, hyperlipidemia and impaired liver enzymes.Method: One hundred and forty-two overweight or obes...

hrp0089p2-p086 | Diabetes &amp; Insulin P2 | ESPE2018

Local Experience of Diabetes and Deafness

Ibrhim Reham , Abdullah Mohamed

Aim: There is a well described association between diabetes and deafness in many syndromes Collect baseline data about syndromes of diabetes and deafness in Sudan and the underline etiology.Methods: All records of patients with diabetes registered from (Jan.2006 to Dece.2015) were reviewed. Those confirmed to have deafness where further reviewed to find the etiology and management.Result: Ten cases of Wolfram syndrome were identifi...

hrp0089p2-p087 | Diabetes &amp; Insulin P2 | ESPE2018

Translating the A1C Assay into Estimated Average Glucose Values in Children with Type 1 Diabetes Mellitus

Sayed Ahmed Mohamed , Alyafei Fawzia , Soliman Ashraf , Algamal Mona

Objective: The A1C assay, expressed as the percent of hemoglobin that is glycated, measures chronic glycemia and is widely used to judge the adequacy of diabetes treatment and adjust therapy. Day-to-day management is guided by self-monitoring of capillary glucose concentrations (milligrams per deciliter or millimoles per liter) as well as by using continuous glucose monitoring systems (CGMS). We found a mathematical relationship between A1C and average glucose (AG) levels meas...

hrp0089p2-p088 | Diabetes &amp; Insulin P2 | ESPE2018

Relationship Between Residual Endogenous Insulin Secretion and Glycemic Control in Japanese Children and Adolescents with Type 1 Diabetes

Musha Ikuma , Kawana Hiroshi , Akatsuka Junya , Ohtake Akira , Amemiya Shin , Kikuchi Toru

Background: Difficulty of glycemic control varies among subjects with type 1 diabetes (T1D). Influence of residual endogenous insulin detected by serum C-peptide (CPR) levels has noted to be on glycemic control. Flush glucose monitoring (FGM) detects glucose concentration in intercellular fluid (sensor glucose) every 15 minutes to reveal daily glucose profiles.Aims: We tried to clarify the relationship between serum CPR and the excursion of blood glucose...

hrp0089p2-p089 | Diabetes &amp; Insulin P2 | ESPE2018

A Curious Case of Persistent Lactic Acidosis in a Child with Diabetic Ketoacidosis

Sng Andrew , Ng Nicholas , Hui-Lin Chin , Lim Yvonne

Summary: An 11 year old girl with poorly controlled type 1 diabetes mellitus (T1DM) presented with persistent lactic acidosis and transaminitis despite resolution of diabetic ketoacidosis (DKA), subsequently confirmed histologically to have glycogen hepatopathy (GH). This case describes a rare but known complication of poorly controlled DM and offers some novel insights in the management of GH.Clinical case: The patient had a history of poor compliance t...

hrp0089p2-p090 | Diabetes &amp; Insulin P2 | ESPE2018

An Unusual Case of an Exclusively Vegan Child with Diabetic Acidosis

Xatzipsalti Maria , Konstantakopoulos Sotiris , Kourti Afroditi , Anastasoudi Maria , Fafoula Olga , Limperatou Christina , Stamogiannou Lela , Vazeou Andriani

Case presentation: A 17 month old female child was transferred to our hospital from another hospital where she was admitted to the intensive care unit (ICU) due to cerebral edema, diabetic acidosis and severe dehydration. The patient had fever, polyuria, polydipsia and vomiting presented four days before admission. At her admission she was unconscious with dilated pupils, no reaction to painful stimuli (GCS 4/15) and Kussmaul breathing. Her initial blood glucose level was 391 ...

hrp0089p2-p091 | Diabetes &amp; Insulin P2 | ESPE2018

HLA-DQ Genotyping in Patients with Type 1 Diabetes Mellitus and Celiac Disease

Agrawal Neeraj , Bhandari Shweta , Andleeb Andleeb Zehra , Singh Usha

Objective and context: Celiac disease (CD) is a common autoimmune disorder in type 1 diabetes (T1D), ranging from 5–10% in Caucasian population. There is limited data on the prevalence of CD in T1D and its association with HLA-DQ in India. We studied the HLA genotyping in patients of T1DM with CD in India.Design: The study was done in case control design.Patients and measurements: In a cross-sectional study, 146 T1D patients a...

hrp0089p2-p092 | Diabetes &amp; Insulin P2 | ESPE2018

Hypertriglyceridemia in Type 1 Diabetes Children During Diabetic Ketoacidosis; Relation to DKA Severity and Glycemic Control

Fawaz Lubna , Musa Noha , AbdelAtty Sahar , Nassef Ahmed

Background: Diabetic ketoacidosis (DKA) is a common, life-threatening complication of type 1 diabetes (T1D). Insulin deficiency impairs lipoprotein lipase (LPL) resulting in elevated serum triglycerides (TG) that usually normalize after establishing IV insulin.Objectives: To study the prevalence of hypertriglyceridemia during DKA in T1D patients and assess its relation to DKA severity and glycemic control after 3 months.Methodology...

hrp0089p2-p093 | Diabetes &amp; Insulin P2 | ESPE2018

Acute Mononeuropathy in an 8-Year-Old-Girl with Newly Diagnosed Type 1 Diabetes

Giza Styliani , Litou Eleni , Kotanidou Eleni P , Koliatos Panagiotis , Kleisarchaki Angeliki N , Tzirtzipis Tasos , Tsinopoulou Vasiliki Rengina , Tihalas Athanassios , Evangeliou Athanassios , Galli-Tsinopoulou Assimina

Introduction: Neuropathy, as a complication of type 1 diabetes (T1D), is a heterogeneous group with chronic polyneuropathy being the most frequent form. Acute mononeuropathy is rare and its pathophysiology has not been elucidated.Purpose: To describe acute mononeuropathy during the course of severe ketoacidosis in an 8-year-old girl diagnosed with T1D.Case report: An 8-year old girl was admitted to the Emergency Department because ...

hrp0089p2-p094 | Diabetes &amp; Insulin P2 | ESPE2018

HLA-G Gene Promoter Methylation Status in Children and Adolescents with Type 1 Diabetes

Mouzaki Konstantina , Kotanidou Eleni P , Fragou Aikaterini , Giza Styliani , Taousani Maria , Serbis Anastasios , Eboriadou-Petikopoulou Maria , Tzimagiorgis Georgios , Galli-Tsinopoulou Assimina

Introduction: HLA-G gene is involved in the control of immune response. It plays a primary role on immune tolerance and may participate in controlling autoimmune responses serving as a potential independent susceptibility marker. HLA-G has been isolated in some secretory granules and on the cell surface of primary islet cells induced to secrete insulin. Subsequently, it could be hypothesized that HLA-G methylation at pancreatic islet could sustain T cell activation and onset o...

hrp0089p2-p095 | Diabetes &amp; Insulin P2 | ESPE2018

Impaired Adrenal Function in Pediatric Patients with Diabetes Mellitus Type 1 Evaluated with Low-Dose Synacthen Test

Kalymniou Marialena , Dimitriadou Meropi , Slavakis Aris , Christoforidis Athanasios

Background: Primary adrenocortical insufficiency (Addison’s disease) is reported to be five more times frequent in adult patients with type 1 diabetes mellitus (T1DM) than in the general population with a multifactorial aetiology involving autoimmune, inflammatory and metabolic mediators. Recent data indicate that more than half of children with T1DM show subnormal cortisol response. Subnormal cortisol response may impair the metabolic control of patients with T1DM as the...

hrp0089p2-p096 | Diabetes &amp; Insulin P2 | ESPE2018

The Incorporation of Available Technologies for Diabetes Care Among Different Worldwide Centers: The ESPE/ISPAD Working Group on Diabetes Technology Survey

Dovc Klemen , Shalitin Shlomit , Hanas Ragnar , Boughton Charlotte , Musolino Gianluca , Battelino Tadej , Nimri Revital , Phillip Moshe

Objective: International Societies for diabetes care are aiming to facilitate and improve the uptake of diabetes technologies. This survey investigated healthcare professional (HCP) evaluation of the role of technology in diabetes care within their centres.Methods: Between April to November 2017, 215 HCPs from six continents (132 Europe, 36 Asia, 23 North and 7 South America, 9 Africa and 8 Australasia) replied to an online survey and provided data for a...

hrp0089p2-p097 | Diabetes &amp; Insulin P2 | ESPE2018

Higher Percentage of Insulin Pump Users at Isle of Man (IOM) – Two Years Observational Data

Varshney Vineet , Kurien Anna , Unsworth Pam , Wallinger Catherine , Gangadharan Arundoss

Introduction: Insulin pump service has changed the outlook of diabetes management in children with diabetes. Studies have shown that better metabolic control is achievable even in patients with poor adherence to medical management. NICE in UK recommends the use of insulin pump for children with poor metabolic control, disabling hypoglycaemia and also when facing challenges with MDI insulin use. National Paediatric Diabetes Audit (NPDA) reports helps to measure our clinical per...

hrp0089p2-p098 | Diabetes &amp; Insulin P2 | ESPE2018

Use of Continuous Glucose Monitoring Systems in the Early Detection And Management of Cystic Fibrosis Related Diabetes in Children

Ogundiya Akinsola , Martin Marion , Katkat Nancy , Thomas Laura , Russell Joanne , Kandasamy Sudhakar , Sze Ng

Background: Development of cystic fibrosis–related diabetes (CFRD) is associated with worse pulmonary function, poorer nutritional status, more chest infections and increased mortality. In cystic fibrosis (CF) patients, abnormality of the 1 hour glucose during Glucose Tolerance test (GTT) is reported to be a better predictor of early CFRD and is associated with decline in pulmonary function compared to the 2-hour glucose level during GTT. We report a case series of 4 pati...

hrp0089p2-p099 | Diabetes &amp; Insulin P2 | ESPE2018

Metabolic Improvement Offered by Medtronic Minimed 640 G Associated to Transient Insulin Perfusion Suspension before Hypoglycemia in Young Patients with Type 1 Diabetes

Al Hage Chehade Ghada , Godot Cecile , Jourdon Isabelle , Lepage Nadine , Eve Schmidt Marie , Polak Michel , Beltrand Jacques

Objective: Fear of hypoglycemia interferes frequently with metabolic control of type 1 diabetes especially in patients under 5 years of age who are at high risk of hypoglycemia and low metabolic control. Medtronic Minimed 640 G insulin pump with Smart Guard technology (suspension of insulin perfusion in predictive hypoglycemia situations) appears to be an adequate system for these patients by reducing the risk of hypoglycemia.Research design and methods:...

hrp0089p2-p100 | Diabetes &amp; Insulin P2 | ESPE2018

The Glycemic Variability in Children with Diabetes Mellitus

Dianov Oleg , Lavrova Ekaterina , Gnusaev Sergey

The glycemic variability (GV) - is the scope of changes in blood glucose levels for a certain period of time. In patients with diabetes mellitus type 1 (DM1), GV are more pronounced, especially in children. The aim: analyze the glycemic variability in children with diabetes mellitus.Materials and methods: 126 children aged from 6 to 17 years with duration from DM 16 years were examined. Investigated: glycated hemoglobin (HbA1c), insulin ...

hrp0089p2-p101 | Diabetes &amp; Insulin P2 | ESPE2018

The Levels of Blood Glucose and Counting of Carbohydrate-Fat-Protein in Diabetic Children Using Pump with Aspart and Glulisine

Doğer Esra , Bozbulut Rukiye , Ercan Şebnem , Kılınc Uğurlu Aylin , Demet Akbaş Emine , Bideci Aysun , Camurdan Orhun , Cinaz Peyami

Introduction: In children with Type 1 diabetes, the insulin dose administered to, fasting blood sugar, the amount of food,contents and glycemic index can affect the postprandial blood sugar. Despite the intensive insulin therapy and carbohydrate (CHO) counting the expected improvements in glycemic control is not observed. Compared to other fast affecting analogues, Insulin glulisine has a faster onset of effect and a shorter duration. It has previously been reported that, in c...

hrp0089p2-p102 | Diabetes &amp; Insulin P2 | ESPE2018

A Novel Missense Variant, p.(Thr405Arg), in the SLC19A2 Gene in an Infant with Thiamine Responsive Megaloblastic Anemia Syndrome Presenting with Anemia and Diabetes but with Normal Hearing

Spehar Uroic Anita , Milenkovic Dragan , De Franco Ellisa , Rojnic Putarek Natasa , Krnic Nevena

Objectives: Thiamine responsive megaloblastic anemia syndrome (TRMA) is characterized by the clinical triad of megaloblastic anemia, non-immune diabetes mellitus and sensorineural deafness. It is a very rare autosomal recessive disease with an increased frequency in consanguineous marriages and isolated communities. The syndrome is due to intracellular thiamine deficiency which is the result of a defective high affinity low performance thiamine transporter pro...

hrp0089p2-p103 | Diabetes &amp; Insulin P2 | ESPE2018

Donohue Syndrome with Hypertrophic Cardiomyopathy

Buluş Derya , Doğer Esra , Sarıcı Dilek , Kayalı Şeyma , Uğurlu Aylin , Kalkan Gokhan

Donohue Syndrome is a rare and lethal autosomal recessive disease caused by mutations in the insulin receptor gene. It presents severe insulin resistance, fasting hypoglycemia, post-prandial hyperglycemia, intrauterine and postnatal growth retardation, dysmorphic features, hypertrichosis. The diagnosis of Donohue syndrome was based on the clinical characteristics, laboratory evaluation and determination of the INSR mutation. We report a Turkish female patient with genetically ...

hrp0089p2-p104 | Diabetes &amp; Insulin P2 | ESPE2018

Age and Exocrine Pancreatic Enzyme Requirements are Major Determinants for Carbohydrate Metabolism Impairment in Children Affected with Cystic Fibrosis

Escudero Janire , Uribe Amalia , Ramon Villa Jose , Argente Jesus , Martos-Moreno Gabriel A.

Introduction: Cystic fibrosis related diabetes (CFRD) is associated with a poorer nutritional status, respiratory function and an increase in mortality rate. Screening is recommended from age 10; however, prediabetic conditions are diagnosed earlier.Objectives: 1) To characterize the degree of carbohydrate metabolism impairment (CMI) in 50 CF patients. 2) To explore the association with clinical parameters as eventual predictors of these conditions.<...

hrp0089p2-p105 | Diabetes &amp; Insulin P2 | ESPE2018

Post-Prandial Hyperinsulinaemic Hypoglycaemia after Oesophageal Surgery in Children

Dastamani Antonia , Malhotra Neha , Guemes Maria , Morgan Kate , Rees Clare , Dattani Mehul , Shah Pratik

Introduction: Post-prandial hyperinsulinaemic hypoglycaemia (PPHH) is a recognised complication of various gastric surgeries in children, but rarely reported after oesophageal atresia repair. We report two children diagnosed with PPHH post-oesophageal surgery and the challenges of their management.Case 1: A 2-year-old boy diagnosed with oesophageal atresia at birth, was surgically repaired requiring six oesophageal dilatations the first year of life. At ...

hrp0089p2-p106 | Diabetes &amp; Insulin P2 | ESPE2018

Congenital Hyperinsulinism: Clinical and Molecular Characteristics – Fluorine-18-L-Dihydroxyphenylalanine Positron Emission Tomography (F-DOPA PET) Scan Results – Treatment Responses and Short Term Outcomes of 5 Patients

Turan Hande , Dagdeviren Cakir Aydilek , Cayir Atilla , De Franco Elisa , Ellard Sian , Sonmezoglu Kerim , Ercan Oya , Olcay Evliyaoglu Saadet

Aim: The most common cause of persistent hypoglycemia and related brain damage in infancy is congenital hyperinsulinism (CHI), due to inappropriate secretion of insülin by pancreatic βcells. The most frequent and most serious mutations are activating mutations in ABBC8 or KCNJ11 genes. Genetic analyses, which might predict the type of lesion, performed in early period and 18f dopa pet scanning are very valuable for treatment choice and follow-up of the patients. In t...

hrp0089p2-p107 | Diabetes &amp; Insulin P2 | ESPE2018

Congenital Hyperinsulinism in a Child with Alagille Syndrome

Khan Durray Shahwar , Dastamani Antonia , Antell Hannah , Shah Pratik

Background: Alagille syndrome (ALGS) is an autosomal dominant genetic disorder, with highly variable phenotype affecting multiple organs. Commonly presents in infancy or early childhood as cholestasis. Mutations in the notch signaling pathway ligand (JAG1) or its receptor (NOTCH2) lead to ALGS. This pathway is important for the pancreatic development. However,no cases of ALGS with Congenital Hyperinsulinism (CHI) have been reported to date.<p class="abste...

hrp0089p2-p108 | Diabetes &amp; Insulin P2 | ESPE2018

Severe Stress-Induced Subcutaneous and Intravenous Insulin Resistance in an Eight Year Old Boy with T1DM, Necessitating Seven Months of IV Insulin, Reversed after Psychiatric Treatment

Ommen CCN van , Hoorweg-Nijman JJG , Stuart H , Deschamps PKH , Stuart AA Verrijn

Background: Persistent severe insulin resistance (IR) in T1DM is infrequent, complex to handle and disabling. Genetic and epigenetic factors play a significant role in the pathophysiology of IR. This case report discusses the potential role of habitual and stress-inducing environmental factors in a school-aged boy with a neurodevelopmental disorder.Case report: We present an eight year old boy with a three year history of T1DM (GAD positive) regulated by...

hrp0089p2-p109 | Diabetes &amp; Insulin P2 | ESPE2018

A Case of Neonatal Diabetes Due to Pancreatic Hypoplasia

Karabouta Zacharoula , Katsafiloudi Maria , Bisbinas Vasiliki , Karametou Margarita , Karali Chrisa , Giannopoulos Andreas

Introduction: Neonatal diabetes mellitus (NDM) is a rare form of insulin-dependent monogenic diabetes mellitus (1/400,000 live births) diagnosed in the first six months of life. It can be either transient or permanent, with abnormalities in the parental chromosome 6q24 and with mutations in genes related to the ATP-sensitive potassium pump in the β-cell membrane respectively.Aim: We describe a male infant, 2.5 months old, diagnosed with NDM and panc...

hrp0089p2-p110 | Diabetes &amp; Insulin P2 | ESPE2018

Neonatal Diabetes Mellitus Caused by a Novel GLIS3 Mutation in Twins

London Shira , Elias-Assad Ghadir , Barhoum Marie Noufi , Felszer Clari , Paniakov Marina , Vainer Scott , Flanagan Sarah , Houghton Jayne , Rakover Yardena Tenenbaum

Background: GLIS3 is a transcription factor involved in the development of pancreatic β-cells, the thyroid, eyes, liver and kidneys. In the pancreas, GLIS3 is expressed at various stages of ductal and endocrine cell development, and is a critical regulator of β-cell development and insulin expression. Mutations in GLIS3 have been recently described as a rare cause of neonatal diabetes and congenital hypothyroidism (CH), reported in only 20 ...

hrp0089p2-p111 | Diabetes &amp; Insulin P2 | ESPE2018

Permanent Neonatal Diabetes, Hepatic Failure and Progressive Left Hemispheric Cerebral Atrophy in a Patient with Wolcott-Rallison Syndrome: A Clinical and Genetic Study from the State of Qatar

Al-Khawaga Sara , Hasnah Reem , Saraswathi Saras , Elawa Ahmed , Hussain Khalid

Background: Wolcott-Rallison syndrome (WRS) is a rare recessively inherited disorder characterized by insulin-dependent diabetes and multiple epiphyseal dysplasia. The disease is also characterized by recurrent episodes of hepatitis or hepatic failure, growth retardation and developmental regression. WRS is caused by biallelic mutations in EIF2AK3, encoding the eukaryotic translation initiation factor-2 kinase 3 (IEF2AK3). EIF2AK3 regulates the synthesis of u...

hrp0089p2-p112 | Diabetes &amp; Insulin P2 | ESPE2018

A Rare Case of Diabetes Mellitus Type 1 in a Child with Neurofibromatosis Type 1

Panoutsou Eleni , Oikonomakou Maria-Zoi , Vallianatou Markella , Koufoglou Eleni , Giannopoulou Sotiria , Eliopoulou Maria

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystemic neurocutaneous disorder characterized by an increased risk of benign and malignant tumor formation (neurofibromas, glioma and gastrointestinal stromal tumor). The incidence has been described to be around 1 in 2,500–3,500 live births, and the estimated prevalence is 1 in 4,000–5,000. Although it was first described by von Recklinghausen in 1882, the formal diagnostic criteria were pub...

hrp0089p2-p113 | Diabetes &amp; Insulin P2 | ESPE2018

Detection and Analysis of Glycometabolism Related Genes in Children Diabetes

Chen Lin QI , Wang Xiao Yan , Wu Hai Ying , Chen Ting , Chen Xiu Li , Sun Hui , Wang Feng Yun

Objective: To know more about the etiology and mechanism of antibody-negative diabetes, screening MODY pathogenicity genes and deepening understanding of islet autoantibody-negative diabetes, so as to individualized precision treatment.Methods: A total of 31 subjects with diabetes who had negative islet autoantibodies and C-peptide ≥0.3 ng/ml were collected. Another group was the type 1 diabetes control group, After informed consent obtained patien...

hrp0089p2-p114 | Diabetes &amp; Insulin P2 | ESPE2018

Gender Characteristics of Responsibility for Their Own Health of Adolescents with Type I Diabetes Mellitus

Kyrylova Olena , Budreiko Olena , Chumak Svitlana

Background: To achieve the compensation of type 1 diabetes, psychological factors that contain individual psychological characteristics of the patient’s personality, his emotional state and responsibility for his own health are important.Objective and hypotheses: The purpose of the study was to study the specifics of responsibility for the health of adolescents with type I diabetes of different sex, depending on the level of glycemic control (GC).</...

hrp0089p2-p115 | Diabetes &amp; Insulin P2 | ESPE2018

Favorable Outcome Despite Prolonged Hypoglycemic Episodes Following a Massive Insulin Overdose: A Case Series

Vollbach Heike , Gohlke Bettina , Schulte Sandra , Woelfle Joachim

Objective: To report on a pediatric case series of massive insulin overdose, its altered pharmacokinetics and the patients favorable outcome.Cases and results: Case 1: 300 IU of insulin aspart were subcutaneously injected into a non-diabetic eight-year-old boy within an extended suicide. After 16 hours he was found unconscious with generalized convulsions. The initial blood glucose concentration was below detection limit. It normalized o...

hrp0089p2-p116 | Diabetes &amp; Insulin P2 | ESPE2018

Effect of a Reduced Fluid Replacement Regimen on the Resolution of Diabetic Ketoacidosis (DKA) in Children

Hapuarachchi Danica Shanee , Ahmed Jaberuzzaman , Gevers Evelien , Moodambail Abdul , Thankamony Ajay

Background: A substantially reduced fluid replacement regimen was introduced in the ‘New’ British Society of Paediatric Endocrinology Diabetes (2015) compared to ‘Old’(2009) guideline for DKA management. However, data on varying fluid replacement regimens is limited and we explored this by comparing outcomes of the 2 guidelines on the resolution of DKA.Methods: In a retrospective audit of consecutively admitted patients (age <18 y...

hrp0089p2-p117 | Diabetes &amp; Insulin P2 | ESPE2018

Prevalence of and Risk Factors for Nonadherence to Insulin Among Paediatric Type 1 Diabetes Patients in Singapore

Chua Brandon , Stephanie Jamie , Lim XIn Yan , Poh Kar Men , Cheen McVin , Lim Soo Ting , Lek Ngee

Introduction: Nonadherence to insulin therapy is a significant problem worldwide, which is associated with poor health outcomes among patients with type 1 diabetes (T1D). It is important to identify the risk factors related to nonadherence to target those at higher risk of diabetic complications. In Singapore, there is a knowledge gap in understanding the risk factors for insulin nonadherence in paediatric patients with T1D.Objectives: To assess the prev...

hrp0089p2-p118 | Diabetes &amp; Insulin P2 | ESPE2018

“What do You Know About Your Diabetes?’: A Qualitative and Quantitative Study of Teenagers and Young Adults’ Understanding of their Disease

Malek Jehanne , Petit-Bibal Cecile , Denis Elsa , Eroukhmanoff Juliette , Filippo Gianpaolo De

Background: Type 1 diabetes (T1D) in teenagers is challenging: the constraints of diabetes add up to the specificities of a delicate age; moreover, this period of life is often associated with impaired metabolic control (i.e. higher hemoglobin A1c - HbA1c). Therapeutic Patient Education (TPE) enables people with chronic diseases to manage their illness and yields benefits in both health and financial terms. The first step of TPE approach is to make an “educational diagnos...

hrp0089p2-p119 | Diabetes &amp; Insulin P2 | ESPE2018

Parental Knowledge and Attitudes Toward Diabetes Mellitus Type 1: A Cross Sectional Study

Albanyan Norah , Albanyan Abdulhameed , Adel Ahmad , Zaiton Mohammed

Introduction: Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by absolute insulin deficiency, it’s usually diagnosed in children and adolescents. According to a recent report from the International Diabetes Federation, Saudi Arabia has 14,900 children with T1DM. The incidence is increasing over the last years with prevalence rates of 48 per 100,000 in the eastern region. Parents play an important role in the management of T1DM in children. As a result, ...

hrp0089p2-p120 | Diabetes &amp; Insulin P2 | ESPE2018

Identifying the Association of Depression and Diabetic Distress in Pakistani Patients Diagnosed with Type 1 Diabetes

Fatima Arooj , Zaidi Syed Sammar Abbas

Background and aims: Depression plays an important role among patients diagnosed with Type 1 Diabetes. It is believed that diabetes distress is recognised as major psychological issue in Pakistan. Our study aims to identify diabetes distress among Pakistani children patients diagnosed with type 1 Diabetes. We also aim to find out the relationship among depression, distress caused by Diabetes and glycemic control.Materials and methods: A cross sectional s...

hrp0089p2-p121 | Diabetes &amp; Insulin P2 | ESPE2018

Role of Breastfeeding in Prevention of Type 1 Diabetes in Pakistan

Fatima Arooj , Zaidi Syed Sammar Abbas

Background: Diabetes Mellitus is the leading cause of morbidity and mortality especially in under developed countries like Pakistan. In type 1 Diabetes, there is autoimmune destruction of β cells which is genetically transmitted. Various factors are responsible for this autoimmune process like early use of cow’s milk, allergic food, absence of breastfeeding and various other factors.Objective: Our study aims to investigate the role of breastfee...

hrp0089p2-p122 | Diabetes &amp; Insulin P2 | ESPE2018

A Young Type 1 Diabetic with Acute Hemichorea: Rare Central Nervous System Complications

Sng Andrew , Lin Jeremy , Zain Amanda , Lim Yvonne

A 20-year old lady with poorly controlled type 1 diabetes mellitus diagnosed since 9 years old, comorbidities of hyperlipidemia and steatohepatitis as well as a history of smoking, presented with an acute 2-day history of involuntary, writhing movements of her left upper and lower limbs. Physical examination confirmed left mild hemiparesis with hemichorea-athetosis. Emergent MRI brain demonstrated abnormal signal in the right caudate nucleus and lentiform nucleus (low T2W/FLAI...