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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

Poster Presentations

Diabetes & Insulin P1

hrp0089p1-p040 | Diabetes & Insulin P1 | ESPE2018

Poor Metabolic Control in Children and Adolescents with Type 1 Diabetes and Psychiatric Comorbidity

Sildorf Stine M , Breinegaard Nina , Lindkvist Emilie B , Tolstrup Janne S , Boisen Kirsten A , Teilmann Grete K , Skovgaard Anne Mette , Svensson Jannet

Objective: Type 1 diabetes in childhood is associated with an increased risk of psychiatric morbidities. We investigated predictors and diabetes outcomes in a pediatric population with psychiatric comorbidities.Research Design and Methods: Nationwide pediatric registerbased study. Data from the Danish national childhood diabetes register (DanDiabKids) and The National Patient Register were collected (1996–2015) for this population-based study. We us...

hrp0089p1-p041 | Diabetes & Insulin P1 | ESPE2018

Concealment of Type 1 Diabetes in Adolescence Affects Adherence to Treatment, Metabolic Control, and Quality of Life

Nir Judith , Leffler Nir , Nagelberg Nessia , Yacobovitz-Gavan Michal , Phillip Moshe , Oron Tal

Introduction: Type 1 diabetes (T1D) is one of the common chronic diseases of childhood. T1D management is affected both by physiological and behavioral factors. Some patients and their parents choose to conceal the disease from others. Concealment of disease status is not unique for T1D, and has been shown to adversely affect clinical outcomes, social support and well-being of patients with other chronic conditions. There is limited data on the effects of concealment of T1D in...

hrp0089p1-p042 | Diabetes & Insulin P1 | ESPE2018

Risky Behaviors of Adolescents with Type 1 Diabetes in Comparison with their Healthy Peers

Karavanaki Kyriaki , Kandyla Betina , Tzavara Chara , Tsitsika Artemis

Introduction: Adolescents with type 1 diabetes mellitus (T1D) may differ from their healthy peers with respect to risky behavior.Purpose: To explore the frequency of risky behaviors of T1D adolescents in comparison with healthy peers and associated factors.Patients and methods: The study population included 174 adolescents, of whom 58 T1D adolescents (mean±SD age 16.3±2.0 years, disease duration 6.7±3.5 years and HbA...

hrp0089p1-p043 | Diabetes & Insulin P1 | ESPE2018

The Effect of Social Burden on Paediatric Diabetes Outcomes

Sales-Luis Madalena , Smith Emma , Ajzensztejn Michal

Introduction: Type 1 diabetes has a major impact on not only the person diagnosed, but also their families/carers. Diabetes control is affected by many factors. Our diabetes patient cohort has a very high level of social burden which we feel impacts significantly on the management of their diabetes.Methods: We performed a retrospective analysis of all young people supported by the Evelina London Children’s Hospital diabetes team in 2017 looking at a...

hrp0089p1-p044 | Diabetes & Insulin P1 | ESPE2018

Parental Anxiety about Hypoglycemia of Children and Adolescents with Type 1 Diabetes Mellitus (T1DM) and the Associated Factors

Ntinou Evangelia , Barbouni Anastasia , Liveri Athanasia , Karavanaki Kyriaki

Introduction: The anxiety for hypoglycemia is a major stress factor for parents of children with T1DM and has been associated with poor diabetic control, reduced insulin doses and school-age children.Purpose: To determine the frequency and severity of parental anxiety for hypoglycemia and the associated factors.Patients and methods: The study included parents [21 (23.9%) fathers and 67 (76.1%) mothers] of 88 T1DM patients, with a m...

hrp0089p1-p045 | Diabetes & Insulin P1 | ESPE2018

Management of Diabetes During Ramadan Fasting in Children and Adolescents: Survey of Physicians’ Perceptions and Practices in the Arab Society of Paediatric Endocrinology and Diabetes (ASPED) Countries

Elbarbary Nancy , Deeb Asma , Habeb Abdelhadi , Beshyah Salem A

Background: Many Muslim adolescents and children insist on fasting during the holy month of Ramadan. There are limited data on the patterns of diabetes management specifically about children and adolescents.Aim: To ascertain the knowledge, attitude, and practices to the management of diabetes during Ramadan fasting among physicians who look after children and adolescents living with diabetes in Arab countries.Methods: An electronic...

hrp0089p1-p046 | Diabetes & Insulin P1 | ESPE2018

Phenotypes of Diabetes and Determinants of Glycemic Control and Diabetes Complications in Haitian Youth Living in Haiti

Dumas Marie-Pier , Sainvil Michele , Altenor Kelty , von Oettingen Julia Elisabeth

Background: In non-Caucasian youth residing in low-income settings, risk of mortality and rates of diabetes complications are substantially higher and clinical phenotypes may be distinct.Objectives: To assess the clinical presentation, glycemic control, and chronic complications of diabetes in Haitian youth residing in Haiti.Methods: Retrospective review between 01/2013–03/2018 of youth 0-25 years with diabetes followed at a c...

hrp0089p1-p047 | Diabetes & Insulin P1 | ESPE2018

Smoke Exposure and Cardio-metabolic Profile in Youth with Type 1 Diabetes

Calcaterra Valeria , Cena Hellas , Schiamo Luca Maria , Montalbano Chiara , Regalbuto Corrado , De Filippo Maria , Klersy Catherine , Larizza Daniela

Aim: To evaluate the relationship between smoking and metabolic parameters in patients affected by type 1 diabetes (T1D)Patients and methods: We enrolled 104 children and young adults (50 females and 54 males) with T1D (aged 16.4±8.6 years). The subjects were divided into three groups according to their smoking habits: no smoking (NS), passive smoking (PS), active smoking (AS). The physical examination of the participants included nutritional status...

hrp0089p1-p048 | Diabetes & Insulin P1 | ESPE2018

Menstrual Cycle Disorders in Young Women with Type 1 Diabetes Mellitus

Paschou Stavroula A , Vryonidou Andromachi , Melissourgou Marina , Kosteria Ioanna , Anagnostis Panagiotis , Goulis Dimitrios G , Chrousos George P , Kanaka-Gantenbein Christina

Background and aim: Epidemiologic observations suggest that women with type 1 diabetes mellitus (T1DM) often suffer from menstrual cycle disorders. There may also be a negative association between the age of onset of T1DM and the age of menarche. Delayed menarche, in turn, may be associated with increased risk for diabetic complications. The aim of this study was to prospectively investigate pathologic manifestations of reproductive function in young women with T1DM and their ...

hrp0089p1-p049 | Diabetes & Insulin P1 | ESPE2018

Life Changing Decisions due to Etiological Genetic Diagnosis in Families of Children with Maturity Onset Diabetes of the Young (MODY)

Bril Gherta , Vaxillaire Martine , Gruber Noah , Mazor-Aronovitch Kineret , Ben-Ami Michal , Ben-David Rachel Frumkin , Yeshayahu Yonathan , Sand Olivier , Bonnefond Amelie , Froguel Philippe , Pinhas-Hamiel Orit

Background: Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of disorders characterized by pancreatic beta-cell dysfunction, and usually referred to monogenic forms of diabetes mellitus to distinguish them from the more common type 1 (T1D) or type 2 diabetes (T2D). Fourteen different MODY genetic subtypes have been identified so far. Making a definite diagnosis is very challenging because of overlapping clinical phenotypes between diabetes subtypes. Neverth...

hrp0089p1-p050 | Diabetes & Insulin P1 | ESPE2018

NBAS Gene Mutation Causes Insulin-Dependent Diabetes Mellitus in a Patient with a Multisystem Disorder Consisting Immunodeficiency and Extremely Short Stature

Giatropoulou Sofia , Konig Rainer , Wudy Stefan A. , Speckmann Carsten , Kury Patrick , Fischer-Zirnsak Bjorn , Clemens Kamrath

We report the case of a 19 years old male patient suffering from a multisystem disease involving of the skeleton, connective tissue, immune system, brain and endocrine system due to compound-heterozygote mutations in the NBAS (Neuroblastoma amplified sequence) gene (c.5741G>A [p.(Arg1914His)]; c.6565_6566insT [p.(Glu2189Valfs*7)]), detected using whole-exome-sequencing. He has an immunodeficiency including decreased CD4+T-cells, B-cells and NK-cells with expanded ...

hrp0089p1-p051 | Diabetes & Insulin P1 | ESPE2018

Identification of Six Novel Mutations in Monogenic Diabetes and Congenital Hyperinsulinism and Detected by Targeted-Exome Sequencing in Korea

Kun Cheon Chong , Young Yoon Ju

Objectives: Monogenic diabetes and congenital hyperinsulinism (CHI) and are common disorders of glucose-regulated insulin secretion in childhood, with 13 causative genes known for MODY and 10 causative genes identified for CHI. Genetic testing for monogenic diabetes and CHI is important for patient care. We aimed to delineate genetic and clinical manifestations of monogenic diabetes and CHI diagnosed by targeted-exome sequencing (TES).Methods: Nine proba...

hrp0089p1-p052 | Diabetes & Insulin P1 | ESPE2018

Genetic Susceptibility to Type 1 Diabetes in Children: Analysis of Polymorphisms rs1990760 – IFIH1, rs20541 – IL13, rs231775 – CTLA 4

Goralczyk Aleksandra , Bossowski Artur , Goscik Joanna , Wawrusiewicz-Kurylonek Natalia , Bossowska Anna , Kretowski Adam

Background: Type 1 Diabetes is influenced by genetic and environmental factors. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene polymorphism and The interferon induced helicase domain 1 (IFIH1) gene are known to be associated with T1DM, but have not been established in a Caucasian children population yet. The interleukin 13 (IL13) gene polymorphisms impact on the development of Type 1 DM in children has not been reported yet.Objective and hypotheses: To e...

hrp0089p1-p053 | Diabetes & Insulin P1 | ESPE2018

Neonatal Diabetes as a First Symptom of IPEX Syndrom

Brandt Agnieszka , Okońska Maja , Hennig Matylda , Mysliwiec Małgorzata , Młynarski Wojciech

Introduction: Immunodysregulation polyendocrinopathy enteropathy x-linked syndrome (IPEX) is characterized by systemic autoimmunity, typically beginning in the first year of life. Most commonly triad of symptoms of diarrhea, dermatitis and endocrinopathy is present.Case report: Presentatlion of male patient, born with body weight 3840 grams and 10 points in Apgar scale. In 13th day of life vomitting and tachypnoe were noted and in laboratory tests hyperg...

hrp0089p1-p054 | Diabetes & Insulin P1 | ESPE2018

CpG Methylation Status Changes within the Protein Tyrosine Phosphatase Non-Receptor Type 22 Gene Promoters in Children and Adolescents of Greek Origin with Type 1 Diabetes

Mouzaki Konstantina , Giza Styliani , Kotanidou Eleni P. , Fragou Aikaterini , Taousani Maria , Eboriadou-Petikopoulou Maria , Tzimagiorgis Georgios , Galli-Tsinopoulou Assimina

Introduction: Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a well-established genetic locus of type 1 diabetes (T1D). The aim of the present study is to compare the methylation level of PTPN22 between children and adolescents of Greek origin with T1D and healthy controls.Patients and Methods: Twenty T1D participants and 20 age-/gender-matched healthy youngsters were enrolled. DNA was extracted from white blood cells, the...

hrp0089p1-p055 | Diabetes & Insulin P1 | ESPE2018

Wolfram Syndrome Case with Hypergonadotropic Hypogonadism: A Novel Mutation

Uzan Tatlı Zeynep , Direk Gul , Hepokur Mervenur , Hatipoglu Nihal , Akın Leyla , Kendirci Mustafa , Kurtoglu Selim

Introduction: A rare cause of diabetes mellitus is Wolfram Syndrome, which arises from mutations in wolframin gene found on chromosome 4. Optic nerve atrophy, diabetes insipidus, sensorineural deafness, psychiatric problems can accompany diabetes mellitus, so it can be also named as DIDMOAD syndrome. Hypergonadotrophic hypogonadism can be rarely observed in Wolfram syndrome. A case of novel homozygous mutation in the wolframin gene has been reported because of concomitant rare...

hrp0089p1-p056 | Diabetes & Insulin P1 | ESPE2018

Different Clinical Findings in Maturity Onset Diabetes of the Young due to B-Lymphocyte Kinase Gene Mutations

Guven Ayla , Yildirimoglu Canan

Background: B-Lymphocyte kinase gene (BLK) gene acts on insulin synthesis and secretion, and mapped locus on chromosome 8p23. Monogenic diabetes due to BLK gene mutation is very rare and it’s named as MODY11. We aimed to present differences in clinical, laboratory and treatment of the patients with BLK mutations.Methods: OGTT performed in six patients. A panel of 23 MODY genes was screened. Patients with BLK</e...

hrp0089p1-p057 | Diabetes &amp; Insulin P1 | ESPE2018

Three New Gene Variants (PTPRD, SYT9, and WFS1) Related to Korean MODY Children Decrease Insulin Secretion in Human Pancreatic Beta Cells

Jang Kyung-Mi , Moon Jung-Eun , Lee Su-Jeong , Lee Gi-Min , Ko Cheol-Woo

Background & objective: Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic β-cell function. MODY has been identified in Asian populations, however, there is a big discrepancy in the genetic locus between Asian and Caucasian patients with MODY. We previously reported that mutations in PTPRD, SYT9 and WFS1 have been identified in Ko...

hrp0089p1-p058 | Diabetes &amp; Insulin P1 | ESPE2018

Comprehensive Genetic Testing Shows One in Five Children with Diabetes and Non-Autoimmune Extra-Pancreatic Features Have Monogenic Aetiology

Patel Kashyap A , Colclough Kevin , Nuri Ozbek Mehmet , Yildiz Melek , Guran Tulay , Kocyigit Cemil , Acar Sezer , Siklar Zeynep , Atar Muge , Johnson Matt B , Flanagan Sarah E , Ellard Sian , Mine Cizmecioglu Filiz , Berberoglu Merih , Demir Korcan , Catli Gonul , Bas Serpil , Akcay Teoman , Demirbilek Huseyin , Weedon Michael N , Hattersley Andrew T

Background/Aim: Diabetes with extra-pancreatic features in children can have a monogenic aetiology. Single gene testing is undertaken when children present with the characteristic clinical features suggestive of the underlying aetiology. We aim to assess the utility of comprehensive genetic testing for all monogenic diabetes genes in children with diabetes and any non-autoimmune extra-pancreatic features from a population with a high rate of consanguinity.<p class="abstext...

hrp0089p1-p059 | Diabetes &amp; Insulin P1 | ESPE2018

Impact of Diabetes During Pregnancy in Women Affected with GCK-MODY on Neonatal Health Outcome

Brandt Agnieszka , Wołoszyn-Durkiewicz Anna , Buraczewska Marta , Kopacz-Petranyuk Katarzyna , Myśliwiec Małgorzata

Introduction: Gestational diabetes is one of the most common medical disorders and may cause numerous maternal and fetal complications. It constitutes one of the most frequent pregnancy health problems and may cause wide range of complications such as: preterm births, congenital defects, sacral agenesis, hypertrophic cardiomyopathy, metabolic changes and macrosomia in neonates. Therefore, early detection and implementation of guideline-based screening tests, are crucial. One o...

hrp0089p1-p060 | Diabetes &amp; Insulin P1 | ESPE2018

IPEX as a Result of Mutations in FOXP3 Two Case Reports and Review of the Literature

Zhu Qiong , Wang Chunlin

Background: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations in the Forkhead/winged helix transcription factor (FOXP3) gene and is a rare disorder that increasingly has gained attention as a model of genetic autoimmunity. We report two Chinese families with IPEX and the sequencing of the FOXP3 gene.Methods: Two unrelated Chinese cases with IPEX were investigated. In case 1, the proband was a 4 month-y...

hrp0089p1-p061 | Diabetes &amp; Insulin P1 | ESPE2018

The Prevalence of Autonomic and Peripheral Neuropathy in Children and Adolescents with Type 1 Diabetic Mellitus (T1D) and Its Association with the Homozygous Status of Z-2/Z-2 Polymorphism of the Aldose Reductase Gene (AKR1B1) in the Polyol Pathway

Kallinikou Dimitra , Tsentidis Charalampos , Kekou Kyriaki , Louraki Maria , Kanaka-Gantenbein Christina , Kanavakis Emmanouil , Karavanaki Kyriaki

Introduction: Diabetic neuropathy (DN) significantly reduces patients’ quality of life and increases cardiovascular death risk. However, it is the least recognized complication of diabetes. Z-2/Z-2 polymorphism of the aldose reductase (AKP1B1) gene increases the expression of the relative enzyme and is likely to contribute to DN expression.Purpose: To study the prevalence of DN in T1D children and adolescents and its associations with the h...

hrp0089p1-p062 | Diabetes &amp; Insulin P1 | ESPE2018

Establishment of Iron Overload Insulin Cell Model and the Effect Induced by Iron Overload on Oxidative Stress

Zhang Lina , Liang Liyang , Meng Zhe , Hou Lele , Liu Zulin

Objective: To establish INS-1 cell iron overload model, and study the effect on proliferation, insulin-secretion and oxidative stress change.Methods: INS-1 cells were cultured in either normal or high glucose medium. Both groups were treated with different concentrations of (5, 10, 20, 40, 80 μmol/l respectively) of ferric ammonium citrate (FAC). Number and state of the cells were detected by trypan blue staining. Labile iron pool (LIP) were calcula...

hrp0089p1-p063 | Diabetes &amp; Insulin P1 | ESPE2018

Glucose Intolerance in Survivors of Childhood Hematologic Disorders

Lee Seonhwa , Choi Yujung , Kim Seul ki , Ahn Moonbae , Chun Min-Kyo , Kim Shinhee , Cho Wonkyoung , Cho Kyoungsoon , Jung Minho , Suh Byungkyu

Purpose: To investigate overall characteristics of glucose intolerance in childhood survivors of hematologic diseases and suggest risk factors which increase A1c (glycated hemoglobin) level.Methods: Based on a retrospective review of 394 children who were diagnosed with acute leukemia or aplastic anemia between 2015 and 2016 under the age of 15, glucose intolerance was observed in 14 patients. A definition of glucose intolerance was A1c above 5.7%. Auxol...

hrp0089p1-p064 | Diabetes &amp; Insulin P1 | ESPE2018

Efficacy of Mecasermin Treatment and Long-Term Survival in a Child with Leprechaunism

Maggio Maria Cristina , Barbetti Fabrizio , Vitaliti Marcello , Ragusa Saveria Sabrina , Vitaliti Giuliana , Corsello Giovanni

Homozygous mutation of Insulin receptor (INS-R) gene cause an extremely rare disease called Leprechaunism, and induce intrauterine growth restriction with poor postnatal growth, hyperinsulinemia, postprandial hyperglycaemia, pre-prandial hypoglycaemia, typical facies, lack of subcutaneous fat, thick skin, hypertrichosis, macrogenitosomia in males. The survival is severely compromised in these patients. Treatment with diazoxide could ameliorate glycaemic control, however these ...

hrp0089p1-p065 | Diabetes &amp; Insulin P1 | ESPE2018

Evaluation of Diabetes Related Complications and Endothelial Dysfunction in Adolescents with Type 1 Diabetes

Metwally Nehad , Macken Alan , O'Regan Myra , Fitzgerald Helen , McDonnell Ciara , O'Gorman Clodagh S , Molloy Eleanor , Roche Edna F

Introduction: Patients with type 1 diabetes (T1D) are at high risk of developing vascular complications. Endothelial dysfunction is considered the early reversible stage in the development of diabetes related vascular disease. Early detection and management of endothelial dysfunction can delay or even prevent the development of vascular complications.Aim: Endothelial dysfunction is associated with poor metabolic control in adolescents with T1D. Based on ...

hrp0089p1-p066 | Diabetes &amp; Insulin P1 | ESPE2018

Complexities in the Management of New-Onset Diabetes after Transplantation (Nodat) in an Adolescent with Senior-Loken Syndrome

Bowen Philippa , Garde Alison , Adams Rebekah , Velleman Sophie , Inward Carol , Giri Dinesh

Background: New-Onset Diabetes after Transplant (NODAT) is a well characterized entity in adult population but less described in paediatric and adolescent population. The development of NODAT is associated with reduced graft function. The consensus for its management is largely available for adult population with a lack of specific guidelines applicable to the paediatric population.Case: A 16-year-old patient with an established renal failure and visual ...

hrp0089p1-p067 | Diabetes &amp; Insulin P1 | ESPE2018

Insulin Resistance Parameters in Children Who Were Born Very Preterm and Adequate for Gestational Age

Garcia Hernan , Poggi Helena , Arancibia Monica , Peredo Soledad , Trincado Claudia , Moore Rosario , D'Apremont Ivonne , Andrade Daniela , Sifaqui Sofia , Ossa JT , Campino Carmen , Carvajal Cristian , Fardella Carlos , Baudrand Rene , Solari Sandra , Allende Fidel , Martinez-Aguayo Alejandro

Background: Very preterm neonates are at risk for metabolic syndrome later in life. Our objective was to compare anthropometric measures and insulin resistance variables between children who were born very preterm (VPT, <32 gestational weeks) and term (T, >37 gestational weeks), and adequate for gestational age (AGA).Methods: In this cross-sectional cohort study we recruited 113 children 5.0 to 8.5 years old from the preterm clinic of our institu...

hrp0089p1-p068 | Diabetes &amp; Insulin P1 | ESPE2018

Impact on Final Height of Functional Insulin-Therapy in Type 1 Diabetes Mellitus Pediatric Patients – Experience from a Portuguese Pediatric Endocrinology Unit

Serra-Caetano Joana , Dias Ana Lopes , Ferraz Ana , Lages Adriana , Miranda Patricia , Cardoso Rita , Dinis Isabel , Mirante Alice

Introduction: Type 1 diabetes mellitus (1DM) has well known long term vascular and neuropathic complications. It has also been described a positive effect of good glycemic control on physical growth and pubertal development, achieved with improvement of insulin-therapy.Aim: To evaluate the effect of functional insulin-therapy on final height in children with type 1 diabetes mellitus.Methods: Retrospective analysis of a cohort of po...

hrp0089p1-p069 | Diabetes &amp; Insulin P1 | ESPE2018

Triglyceride Glucose Index as a Predictor of Impaired Glucose Tolerance in Overweight and Obese Adolescents

Phatarakijnirund Voraluck , Kooanantkul Chula , Sanor Warissara , Numbenjapon Nawaporn , Mungklarat Pacharin

Background: Triglyceride glucose (TyG) index, a product of fasting triglyceride and glucose, was widely used as an alternative tool for identifying insulin resistance in adults but not in children. Recent study in children showed association between the TyG index and HOMA-IR and a usefulness of TyG index as a surrogate marker of insulin resistance among adolescents.Objective: To evaluated the potential role of the TyG index as a predictor of impaired glu...

hrp0089p1-p070 | Diabetes &amp; Insulin P1 | ESPE2018

Birth Weight in Offsprings of Mothers with Gestational Diabetes Mellitus due to Mutations in GCK Gene

Zubkova Natalia , Burumkulova Fatima , Petrukhin Vasily , Plechanova Margarita , Panov Anton , Ulyatovskaya Victoria , Makretskaya Nina , Tiulpakov Anatoliy

Background: The prevalence of MODY2 in the gestational diabetic population has been estimated to be approximately 2%. Risk of macrosomia in GCK/GDM cases depends on maternal glycemic control and fetal mutation status. However, the fetal genotype is unknown before birth. We assessed the effects of insulin therapy on the birth weight of children born to mothers with GCK mutations.Objective and hypotheses: The study included 38 patients with GDM due to GCK ...

hrp0089p1-p071 | Diabetes &amp; Insulin P1 | ESPE2018

Review and Audit of Diabetes Control in Children and Young People with Diabetes Using the FreestyleLibre Flash Glucose Scanning System (FGS)

Zahid Aisha , Sachdev Pooja , Denvir Louise , Randell Tabitha , Drew Josephine

Background: The Freestyle Libre Flash Glucose Scanning System (FGS) is a glucose sensing technology device for people with diabetes to monitor plasma glucose levels, reducing the need for routine fingerpricks. The device is worn on the upper arm and produces graphs displaying glucose levels over a period of time. Trials of the Freestyle Libre device have been utilised at Nottingham Children’s Hospital (NCH), providing the device is used safely. Potential for most benefit ...

hrp0089p1-p072 | Diabetes &amp; Insulin P1 | ESPE2018

Increasing Use of Continuous Glucose Monitoring (CGM) Among Youth with Type 1 Diabetes (T1D): Icomparison of Youth from the T1D Exchange (T1DX) and the DPV Initiative

Miller Kellee , Hermann Julia , Maahs David , Hofer Sabine , Foster Nicole , Holl Reinhard

Objectives: To assess change in rates of pediatric CGM use over the past 5 years across demographic and clinical characteristics and association with hemoglobin A1c (HbA1c), data from 2 registries were compared: the US-based T1DX and the German/Austrian DPV.Methods: Registry participants in DPV and T1DX aged <18yrs with T1D duration ≥ 1yr with available data in any of the following years were included in the analysis (N for each year by registr...

hrp0089p1-p073 | Diabetes &amp; Insulin P1 | ESPE2018

Efficacy of Real-time Continuous Glucose Monitoring in Type 1 Diabetic Pre-school and School Children Treated with Multiple Daily Injections

Schiaffini Riccardo , Rapini Novella , Pellicano Grazia , Patera Patrizia Ippolita , Ciampalini Paolo , Matteoli Maria Cristina , Deodati Annalisa , Cianfarani Stefano

Background: Young children affected by Type 1 Diabetes (T1D) are prone to glucose fluctuations and hardly reach a stable glycometabolic control, especially when treated with a Multiple Daily Insulin Injections (MDI) scheme. The recent Real-Time Continuous Glucose Monitoring (RT-CGM) System, Dexcom G5, the only available device registered for non-adjunctive insulin intervention, potentially facilitates a better management of the disease. Evidence regarding CGM effectiveness amo...

hrp0089p1-p074 | Diabetes &amp; Insulin P1 | ESPE2018

Catheter Site Selection and Anthropometric Measurements at Subjects with Type 1 Diabetes and Continuous Subcutaneous Insulin Infusion

Xatzipsalti Maria , Vakaki Marina , Mentesidou Lida , Kourti Afroditi , Patouni Konstantina , Choundala Anna , Stamogiannou Lela , Vazeou Andriani

Introduction: The selection of the insulin catheter length for pump T1D users is based mainly on age and though different sites for insertion have been suggested, it is not clear what the ideal site is according to each person’s body type and subcutaneous fat.Aid: Aid of the study is to identify the proper sites for insulin catheter insertion according to subcutaneous fat and anthropometric characteristics.Methods: Study group...

hrp0089p1-p075 | Diabetes &amp; Insulin P1 | ESPE2018

Open Source Artificial Pancreas Systems Used from Bulgarian Children and Young People with Diabetes

Konstantinova Maia , Kozak Milos , Radev Radoslav , Pandova Rositza , Dimova Hristina , Georgiev Rumen

Introduction: The new technologies in diabetology improved not only HbA1c, but also ‘Time in range’, ‘Glycemic variability Index ‘/GVI/, and ‘Patient’s Glycemic Status’ /PGS/. Parents of children and patients with diabetes demonstrated impatience for artificial pancreas systems /APS/. They initially created ‘Nightscout’ platform for remote monitoring of the glucose sensors and then – Do It Youself Open Source Artificial Pancrea...

hrp0089p1-p076 | Diabetes &amp; Insulin P1 | ESPE2018

National Survey of Usage of Continuous Glucose Monitoring in Children and Adolescents at Non Reimbursed Setting

Bazdarska Yuliya , Iotova Violeta , Mladenov Vilhelm , Boyadzhiev Veselin , Petrova Chayka , Halvadjian Irina , Savova Radka , Popova Galina , Koleva Reni , Moskova Mariyana , Kaleva Nartsis , Nedyalkova Diana

Background: Continuous glucose monitoring (CGM) correlates with optimal control in both children and adults with type 1 diabetes (T1D) regardless of type of treatment. CGM plays a major role in decreasing the time spent in hypoglycemia and hyperglycemia, and achieving better quality of life.Aim: To evaluate the usage and benefits of out-patient CGM and assess parents’ attitudes to it at a non-reimbursed setting.Methods: A tota...

hrp0089p1-p077 | Diabetes &amp; Insulin P1 | ESPE2018

Additional Insulin is Necessary to Prevent Rise in Blood Glucose after Fat-protein-rich Meals in Type 1 Diabetes

Schweizer Roland , Herrlich Susann , Losch-Binder Martina , Glokler Michaela , Heimgartner Magdalena , Liebrich Franziska , Meszner Katja , Muckenhaupt Tina , Schneider Angelika , Ziegler Julian , Neu Andreas

Background: High amounts of protein in meals increase blood glucose in patients with type 1 diabetes. Fat delays the increase of blood glucose. Till now we do not know the amount of insulin necessary to prevent the increase of blood glucose after a fat and protein rich meal (FPRM).Aim: To find the Insulin dosage to normalize glucose level after a FPRM.Patients: Sixteen patients with type 1 diabetes (mean±SD; Age 19.7±2.7 ...

hrp0089p1-p078 | Diabetes &amp; Insulin P1 | ESPE2018

Efficacy of Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Childhood Type 1 Diabetesefficacy of Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Childhood Type 1 Diabetes

Pei Zhou , Sun Chengjun , Wang Hongsheng , Zhai Xiaowen , Luo Feihong

Objective: To observe and analyze the efficacy and safety of autologous stem cell transplantation (AHSCT) in children with type 1 diabetes.Methods: Twelve children were enrolled in our study who were newly diagnosed as type 1 diabetes in Children’s Hospital of Fudan University from Sep 2009 to Dec 2011. Changes in the exogenous insulin requirement were observed and HbA1C and C peptide level were measured before and after AHSCT.<p class="abstext"...

hrp0089p1-p079 | Diabetes &amp; Insulin P1 | ESPE2018

A Novel SLCA16A1 Mutation in an Infant with Hypoglycemia and Severe Metabolic Ketoacidosis

Hasnah Reem , Al-Khawaga Sara , Saraswathi Saras , Haris Basma , Saeed Amira , Sharari Sanaa , Mohammed Idris , Hussain Khalid

Background: Recurrent episodes of ketoacidosis with or without hypoglycemia have been reported with homozygous or heterozygous mutations in the solute carrier family 16 member 1 (SLC16A1) gene. This gene encodes for the monocarboxylate transporter 1 (MCT-1) which plays a key role in lactate, pyruvate and ketone body transport.Objective(s): To describe the youngest patient with a novel SLC16A1 gene who presented with recurrent episodes of ketoacidosis and...

hrp0089p1-p080 | Diabetes &amp; Insulin P1 | ESPE2018

Successful Transition to Sulfonylurea Therapy in Infant with Neonatal Diabetes, Developmental Delay, Epilepsy (DEND Syndrome) due to F132L ABCC8 Mutation

Tikhonovich Yulia , Zubkova Natalia , Petryaikina Elena , Ribkina Irina , Garyaeva Irina , Tiulpakov Anatoly

Introduction: The heterozygous activating mutations in the KCNJ11 and ABCC8 are the commonest causes of permanent neonatal diabetes mellitus (PNDM). The most severe clinical form of NDM is DEND syndrome. Besides diabetes mellitus such patients show severe developmental delay, hypotonia and therapy-resistant epilepsy. To our knowledge only some cases of DEND syndrome due to ABCC8 mutations are sulfonylurea-responsive. Here we report case of DEND syndrome due t...

hrp0089p1-p081 | Diabetes &amp; Insulin P1 | ESPE2018

ZFP57-associated Transient Neonatal Diabetes is Responsive to Oral Sulfonylurea Treatment

Reinauer Christina , Jonasson Annemarie , Harmsen Stefani , Debinski Pierre , Soditt Volker , van Afferden Sonia , Mayatepek Ertan , Bergmann Carsten , Meissner Thomas , Kummer Sebastian

Background: Transient neonatal diabetes (TNDM) is commonly caused by a methylation loss in the 6q24 region, either in isolation or as multiple-loci demethylation due to ZFP57 gene mutation. TNDM is biphasic; usually resolves after 2–3 months but often recurs between age 4 and late adolescence.Case: The boy was born at 38 weeks of gestation (birth weight 3340 g, healthy consanguineous Turkish parents, unremarkable pregnancy). He presented at...

hrp0089p1-p082 | Diabetes &amp; Insulin P1 | ESPE2018

The Comparison of the Occurrence of Beta Cells Autoantibody and Regulatory T Cells (CD4+CD25+FoxP3+) in Patients with Type 1 Diabetes Mellitus, their Siblings and Healthy Children

Sieniawska Joanna , Krzewska Aleksandra , Ben-Skowronek Iwona

Background: Regulatory T cells (Treg) of phenotype CD4+CD25+FoxP3+ involves active suppression of excessive immune response. The population of Treg cells from patients with type 1 diabetes (DM1) have numeric and functional abnormalities. Although there are many reports of investigations on human and animal populations, the role of regulatory T cells in the development of type 1 diabetes is still unclear.Objective and hypotheses: The aim of the study is t...

hrp0089p1-p083 | Diabetes &amp; Insulin P1 | ESPE2018

HERV-W-Env Protein Expression in Pediatric Type 1 Diabetes Patients

Bouthors Therese , Elowe-Gruau Eglantine , Diaz-Escagedo Patricia , Antoniou Maria-Christina , Stoppa-Vaucher Sophie , Levet Sandrine , Medina Julie , Demolder Amandine , Perron Herve , Hauschild Michael

Introduction: The envelope protein of Human Endogenous Retrovirus type W (HERV-W-Env) has been shown to be associated with type 1 diabetes (T1D) pathogenesis in adults patients. This protein is expressed in pancreas of T1D patients and it seems to correlate with macrophage infiltrations. In vitro and in vivo studies have demonstrated that HERV-W-Env inhibits insulin secretion and promotes hyperglycemia. Furthermore, HERV could be implicated in other auto-immune disorders. The ...

hrp0089p1-p084 | Diabetes &amp; Insulin P1 | ESPE2018

The Comparison of the Occurrence of Beta Cells Autoantibody and Natural Killer Cells in Patients with Type 1 Diabetes Mellitus, Their Siblings and Healthy Children

Sieniawska Joanna , Krzewska Aleksandra , Ben-Skowronek Iwona

Background: Natural killer cells are a type of cytotoxic lymphocyte critical to the innate immune system. NK cells from patients with type 1 diabetes (DM1) have numeric and functional abnormalities. However, little is known about the number of NK cells in healthy siblings of children with DM1.Objective and hypotheses: The aim of the study is to compare the population of NK cells and the correlation between NK cells and beta cells autoantibody in healthy ...

hrp0089p1-p085 | Diabetes &amp; Insulin P1 | ESPE2018

T- and B-Lymphocytes Levels in Children with Type 1 Diabetes in Association with Candida Infection

Elkina Stanimira , Blajeva Svetla , Halvadzhiyan Irina , Botzova Venetziya , Petrova Chayka

Although type 1 diabetes (T1D) is most common autoimmune chronic metabolic disease in childhood, data about the role of T-Lymphocytes (T-Ly) and B-Lymphocytes (B-Ly) in children after the diabetes onset are still controversial. The aim of the study was to evaluate the serum levels of T– and B-Ly in children with T1D as a predisposing factor for genital candidiasis (GC).Material: We studied 71 children with T1D at the age of 6 to 18 years, divided in...

hrp0089p1-p086 | Diabetes &amp; Insulin P1 | ESPE2018

Coincidence of Newly Diagnosed Type 1 Diabetes Mellitus with Enteroviruses and Respiratory Tract Viruses

Karaoglan Murat , Eksi Fahriye , Keskin Mehmet , Karaoglan İlkay

Background: Viruses, which trigger and promote islet cell destruction, cause type 1 diabetes mellitus (T1DM). However, the existence of a cause-and-effect relationship is under debate. The aim of this study was to investigate sero-epidemiological and molecular evidence of enteroviruses and respiratory viruses in patients with newly diagnosed T1DM during cold season.Methods: This study included 40 children with newly diagnosed T1DM and 30 healthy children...

hrp0089p1-p087 | Diabetes &amp; Insulin P1 | ESPE2018

Investigation into β-cell Adaptation During Puberty

Castell Anne-Laure , Ethier Melanie , Fergusson Grace , Ghislain Julien , Poitout Vincent

Background: Puberty is a time of hormonal changes that are associated with insulin resistance. Although insulin sensitivity is restored at the end of puberty in healthy youth, it does not resolve in obese adolescents leading to an increase of cardio metabolic disease such as type 2 diabetes. In response to an increase in insulin demand, as during pregnancy or obesity-induced insulin resistance, β-cells increase their functional mass to maintain glucose homeostasis. Howeve...

hrp0089p1-p088 | Diabetes &amp; Insulin P1 | ESPE2018

The Shape of the Glucose Curve and Time to Glucose Peak During an Oral Glucose Tolerance Test as Indicators of Beta Cell Function in Obese Adolescents

Sabolić Lavinia La Grasta , Stipančić Gordana , Šepec Marija Požgaj

Introduction: Morphological characteristics of the glucose concentration curve during an oral glucose tolerance test (OGTT) may reflect differences in insulin secretion and sensitivity. Whether the shape of the glucose curve and time to peak glucose concentration can be used as indicators of beta cell function and markers of type 2 diabetes risk in obese adolecents is still uncertain.Aims/hypothesis: The purpose of this cross-sectional study was to asses...

hrp0089p1-p089 | Diabetes &amp; Insulin P1 | ESPE2018

Features of T2DM in Adolescents with Low Titer of ICA and IAA

Eremina Irina , Kuraeva Tamara , Zilberman Lubov , Peterkova Valentina

Purpose: To assess the prevalence of pancreatic autoantibodies (Ab) and their impact on the course of type 2 diabetes mellitus (DM2) in adolescents.Materials and methods: ICA, GADA, IA-2 and IAA were measured in 66 patients with DM2. Depending on the presence of autoantibodies (Ab) patients were divided into 2 groups: Ab- and Ab+. HLA-typing was carried out in 45 patients. The secretion of C-peptide in the standard carbohydrate brea...

hrp0089p1-p090 | Diabetes &amp; Insulin P1 | ESPE2018

Increasing Trend of Fasting Plasma Glucose Levels and Impaired Fasting Glucose in Non-Diabetic Korean Youth and Young Adults: A Nationally Representative Population-Based Study

Lee Jieun , Ah Lee Young , Hyun Kim Jae , Yong Lee Seong , Ho Shin Choong , Won Yang Sei

Objectives: Diabetes in children and young adults is increasing worldwide. However, the study of change in fasting glucose among general pediatric and young adult population was lacking. The aim of this study was to investigate the secular trend of fasting plasma glucose (FPG) levels in non-diabetic Korean youth and young adults and to evaluate the change in the proportion of impaired fasting glucose (IFG).Methods: Study subjects were Korean youth aged 1...

hrp0089p1-p091 | Diabetes &amp; Insulin P1 | ESPE2018

Screening for T2D in High Risk Egyptian Children and Adolescents Using Strip HbA1c and OGTT

Hafez Mona , Musa Noha , Mansour Mona , Hamdy Heba

Background: The prevalence of type 2 diabetes (T2D) is significantly increased in pediatric population, which is affected by obesity worldwide. The progression of insulin resistance to T2D in obese children has been shown to be faster than in adults. Therefore, screening for T2D seems meaningful especially in high risk groups such as children and adolescents with obesity, family history of T2D, and those with clinical features of insulin resistance (hypertension, dyslipidemia,...

hrp0089p1-p092 | Diabetes &amp; Insulin P1 | ESPE2018

Association of the Sizes and Composition of HDL with Hepatic Steatosis in Adolescents with Type 2 Diabetes (T2D)

Antonio Orozco Morales Jose , Torres Tamayo Margarita , Medina Urrutia Aida , Gabriel Juarez Rojas Juan , Reyes Barrera Juan , Jorge Galarza Esteban , Dies Suarez Pilar , Medina Bravo Patricia

Background: Type 2 diabetes (T2D) is an emerging disease in the pediatric population. The association between T2D and non-alcoholic fatty liver disease (NAFLD) has been described; this increases the risk of coronary heart disease (CHD). Recent evidence suggests that sizes and composition of HDL may be more important that HDL-C levels in predicting CHD. There is not data regarding the HDL subclasses distribution and composition in T2D youths with hepatic steatosis (HE).<p c...