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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

Poster Presentations

Fat, Metabolism and Obesity P2

hrp0089p2-p123 | Fat, Metabolism and Obesity P2 | ESPE2018

Allopurinol Ameliorates Non-Alcoholic Fatty Liver Disease in Rats

Anil Korkmaz Huseyin , Aktug Huseyin , Atila Dincer , Barisik Vatan , Arslan Nur , Erbas Oytun

Background: Hyperuricemia has been found to be associated with non-alcoholic fatty liver disease (NAFLD).Aim: The aim of this study was to evaluate whether allopurinol affects the course of experimental NAFLD in rats.Study Design: Mature, albino Sprague Dawley rats were fed water containing 30% fructose without ethanol for up to 8 weeks. After demonstration of steatosis in the 8th week, either allopurinol or saline was administered...

hrp0089p2-p124 | Fat, Metabolism and Obesity P2 | ESPE2018

Relationships of Dietary Intake and Sugar Rich Products Consumption with Hepatic Fat Content and Insulin Resistance among Children with Overweight/Obesity: The PREDIKID Study

Aranaza Lide , Diez-Lopez Ignacio , Medrano Maria , Oses Maddi , Huybrechts Inge , Ortega Fran B , Labayen Idoia

Pediatric non-alcoholic fatty liver disease (NAFLD) has increased in parallel with childhood obesity. Dietary habits, particularly products rich in sugars, may influence both hepatic fat content and insulin resistance. Hence, the aim of the current study was to examine the associations of the consumption of dietary foods (cereals, fruits and vegetables, meat and meat products, dairy products, fish and shellfish, total and added sugars) and composition (macronutrients and fiber...

hrp0089p2-p125 | Fat, Metabolism and Obesity P2 | ESPE2018

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Egyptian Obese Children and Adolescents: Relation to Hypertension Risk

Hamza Rasha , Elkabbany Zeinab , Kamal Tarek , Sedhom Mina

Background: Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies have examined the contribution of ACE candidate genes for development of the obesity-hypertension phenotype early in life.Aim: To screen Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in the gene encodi...

hrp0089p2-p126 | Fat, Metabolism and Obesity P2 | ESPE2018

Serum Calprotectin Level in Children: Marker of Obesity and Its Metabolic Complications

Calcaterra Valeria , Amici Mara De , Silvestri Annalisa De , Michev Alexandre , Montalbano Chiara , Regalbuto Corrado , Schiano Luca Maria , Cena Hellas , Larizza Daniela

Aim: Circulating levels of calprotectin have been reported in obesity-related chronic low-grade inflammation in adults, but has not been evaluated in pediatric population. We investigated serum calprotectin in overweight and obese children and its association with metabolic comorbidities.Methods: We enrolled 131 children (11.7±4.1 years). According to BMI, the subjects were divided into three groups: obese >95th percentile; overweight BMI 75th&#...

hrp0089p2-p127 | Fat, Metabolism and Obesity P2 | ESPE2018

Pediatric Continuous Metabolic Syndrome Score (PsiMS score): Use in Everyday Clinical Practice

Vukovic Rade , Soldatovic Ivan , Milenkovic Tatjana , Mitrovic Katarina , Todorovic Sladjana , Plavsic Ljiljana

Introduction: Dichotomous nature of current definition of metabolic syndrome (MS) in youth results in loss of information. On the other hand, the complex calculation of continuous MS scores using standardized residuals in linear regression (Z scores) or factor scores of principal component analysis (PCA) is demanding and highly impractical for clinical use. Recently, a novel, easily calculated continuous MS score called Pediatric siMS score (PsiMS score) was developed based on...

hrp0089p2-p128 | Fat, Metabolism and Obesity P2 | ESPE2018

Leptin and Cytokines are Not the Best Markers for Metabolic S

Cuartero Beatriz Garcia , Vergaz Amparo Gonzalez , Lacalle Concepcion Garcia , Escudero Veronica Sanchez , Salado Laura Sanchez , Larramendi Carmen Hernando de

Introduction: Leptin, some cytokines and triglycéride/colesterol -HDL ratio (TG/C-HDL ratio) are markers of insulin-resistance in children and adolescents with overweight/obesity. Due to the high prevalence of this pathology it’s necessary to find and easy and better routinely marker that identify these patients in the outpatient clinic. Previous results demonstrated that TG/C-HDL ratio >2 was a better predictor of metabolic syndrome (sensitivity 100%; specificit...

hrp0089p2-p129 | Fat, Metabolism and Obesity P2 | ESPE2018

Early-Life Risk Factors and Their Association with Hypertension in Spanish Children and Adolescents

Perez-Gimeno Gloria , Ruperez Azhara I , Gil-Campos Mercedes , Leis Rosaura , Aguilera Concepcion M , Gil Angel , Moreno Luis A , Bueno-Lozano Gloria

Introduction: In the last years, the prevalence of high blood pressure (HBP) has increased in children, contributing to raise the risk of future cardiovascular disease. It is known that family history, pregnancy characteristics and type of feeding in the first months of life are of great importance in the prevention of diseases in the offspring. In this study we aimed to investigate the association between early life risk factors and HBP in children and adolescents.<p clas...

hrp0089p2-p130 | Fat, Metabolism and Obesity P2 | ESPE2018

A Rare Case of Diabetes Mellitus in an Adolescent: Partial Lipodystrophy

Ozen Samim , Ata Aysun , Gokşen Damla , Akıncı Barış , Tuncer Canan Altay , Darcan Şukran

Introduction: Lipodystrophies are heterogeneous group of disorders; characterized by congenital or acquired loss of fat tissue. These disorders can causes severe metabolic complications during childhood. Case: 10.5 years old girl admitted to our clinic due to pigmented lesions on her body. She was investigated due to sclerotic lesions on her legs when she was 8 years old and was diagnosed as scleroderma and methotrexate was initiated. On physical examination weight was 47 kg (...

hrp0089p2-p131 | Fat, Metabolism and Obesity P2 | ESPE2018

Visfatin, RBP4 and STRA6 polymorphisms’ in relation with Childhood Obesity

Pascanu Ionela , Pop Raluca , Vasilache Simona , Marginean Oana , Moldovan Valeriu , Banescu Claudia

Background: Several visfatin, retinol binding protein 4(RBP4) and high affinity receptor for RBP4, STRA6 (stimulated by retinoic acid) single nuclear polymorphisms’ (SNP) have been investigated regarding their relationship with obesity with controversial results.Aim: To analyze the association of two specific SNP for visfatin, RBP4 and STRA6 with anthropometric markers of obesity in children.Material and method: A case control...

hrp0089p2-p132 | Fat, Metabolism and Obesity P2 | ESPE2018

Characteristics of Blood Lipids in Boys with Hypoandrogenia

Budreiko Olena , Kosovtsova Ganna , Nikitina Larisa

Discussed in literature is primarily the impact of late-onset hypogonadism in men as a factor of development of endothelial dysfunction, insulin resistance and systemic inflammation, while the pathogenic role of hypoandrogenia in development of metabolic disorders in male individuals during puberty currently remains undetermined.Aim of research: To determine characteristics of lipid profile in adolescent boys with hypoandrogenia.Ma...

hrp0089p2-p133 | Fat, Metabolism and Obesity P2 | ESPE2018

Tri-Ponderal Mass Index: A Good Anthropometric Index to Evaluate Adiposity in Children and Adolescents

Klunder Miguel Klunder , Peregrina Myrna Bravo , Gonzalez Desiree Lopez , Clark Patricia , Lora America Liliana Miranda

Background: The adiposity measurement by reliable methods such as dual X-ray absorptiometry (DXA) is not feasible in routine medical care and instead of this, the anthropometric methods are used. However, these methods could be inaccurate to estimate the body fat content. Additionally, in pediatric patients, some anthropometric indexes requires percentiles or Z-scores for their interpretation, like the body mass index (BMI) or the waist circumference (WC). Although anthropomet...

hrp0089p2-p134 | Fat, Metabolism and Obesity P2 | ESPE2018

Serum Spexin Concentrations in Adolescent Females with Metabolic Syndrome, Polycystic Ovary Syndrome and Anorexia Nervosa

Bacopoulou Flora , Efthymiou Vasiliki , Apostolaki Despoina , Tsitsimpikou Christina , Tsarouhas Konstantinos , Darviri Christina , Mantzou Aimilia

Background: Spexin is a novel hormone that may potentially impact food intake, weight regulation and body adiposity. Circulating spexin has been associated with obesity and insulin resistance indices in women.Objective: The aim of this study was to determine serum spexin concentrations in adolescent females with metabolic syndrome, with polycystic ovary syndrome (PCOS), with anorexia nervosa as well as in healthy controls, and explore possible relationsh...

hrp0089p2-p135 | Fat, Metabolism and Obesity P2 | ESPE2018

A Simple Relaxation Exercise Reduces Stress in Obese Youth - A Path to a Healthy Lifestyle?

Stasinaki Aikaterini , Buchter Dirk , Shih C.-H. I. , Heldt Katrin , White Catherine , Ruegger Dominic , Filler Andreas , Gindrat Pauline , Durrer Dominique , Brogle Bjorn , Farpour-Lambert Nathalie , Kowatsch Tobias , L'Allemand Dagmar

Introduction: Lack of impulse control and impaired stress regulation may explain the development of obesity and its challenging therapy, already in youth. To improve self-regulation of overweight adolescents and subsequently their weight status, we tested, whether a biofeedback relaxation exercise decreases stress and whether relaxation services implemented in a novel Smartphone App supported intervention have effects on stress and weight outcomes.Method...

hrp0089p2-p136 | Fat, Metabolism and Obesity P2 | ESPE2018

Dyslipidemia and Its Related Factors in Chinese Children and Adolescents with Turner Syndrome

Huang Siqi , Chen Hongshan , Du Minlian , Li Yanhong , Ma Huamei , Chen Qiuli , Zhang Jun , Guo Song

Turner syndrome is associated with insulin resistance, increased incidence of type II diabetes, and hypertension, all of which are cardiovascular risk factors. The purpose of this study was to evaluate the lipid profile of Chinese girls with untreated Turner syndrome, (aged 2 to 15 years; 50.9% 45,XO) and age-matched, normal girls. A total of 108 girls with Turner syndrome and 99 normal girls had lipid profile measurements, including cholesterol, triglycerides,high-density lip...

hrp0089p2-p137 | Fat, Metabolism and Obesity P2 | ESPE2018

Severity, Duration and Phenotype of Obesity Promote Precocious Cardiovascular Sonographic Alterations in Childhood Obesity

Corica Domenico , Aversa Tommaso , Oreto Lilia , Calabro Maria Pia , Longobardo Luca , Catalfamo Marta , Alibrandi Angela , Luca Filippo De , Wasniewska Malgorzata

Introduction: Childhood obesity is known to be associated with an increased risk of cardiovascular and metabolic complications in adulthood.Objectives: To evaluate precocious cardiovascular sonographic modifications in a cohort of overweight (OW) and obese (OB) children and adolescents brought to Outpatient Clinic of Pediatric Endocrinology for first evaluation, compared with normal weight controls. 2) To investigate the association between clinical and ...

hrp0089p2-p138 | Fat, Metabolism and Obesity P2 | ESPE2018

Physical Activity Determined by Accelerometry Before and After an Integral Treatment Program in Children with Abdominal Obesity

Azcona Maria Cristina , Morell Lydia , Ochotorena Amaia , Ana Ojeda , Leon Jose Luis , Prados Monica , Chueca Maria , Marti Amelia , GenoI Other members Grupo

Introduction: Physical activity (PA) is one of the treatments to promote weight loss in children with obesity. The WHO advices to perform moderate to vigorous (MV) PA during 60-min daily. It is necessary to measure the effect of increasing PA and the adherence to therapy.Aims: To evaluate PA using accelerometry at the onset and after 8 weeks of treatment with nutritional intervention and increase in PA.Patients, material and method...

hrp0089p2-p139 | Fat, Metabolism and Obesity P2 | ESPE2018

The Associations Between Neck – and Upper Arm Circumference with Cardiometabolic Risk Over Traditional Risk Factors in Adolescents - Data from Five EUROPEAN Countries (PreSTART-Study)

Weihrauch-Bluher Susann , Petroff David , Brady Emer M. , Gray Laura J. , Ribeiro Rogerio T. , Vergara Mitxeltorena I. , Gerasimidi-Vazeou Diana A. , Davies Melanie J.

Background: Prevalence and severity of obesity and associated comorbidities are increasing in adolescents. Data on neck and upper arm (UA) circumference in addition to established anthropometric measures to define cardiometabolic risk are limited to date.Methods: Data from Phase I of the EU-funded PreSTART-study (trial registration number NCT02545140) was applied. Demographic, clinical, biochemical and lifestyle data were collected in adolescent...

hrp0089p2-p140 | Fat, Metabolism and Obesity P2 | ESPE2018

Sex-related Differences and Effect of Puberty on Metabolic Syndrome in Obese Children and Adolescents

Guzzetti Chiara , Ibba Anastasia , Casula Letizia , Pilia Sabrina , Loche Sandro

Introduction: Metabolic syndrome (MS) is a known complication of obesity. It is still unclear whether gender and puberty influence the prevalence of MS in children and adolescents.Objective: Aim of the study was to evaluate the effect of gender and puberty on the prevalence of MS and on cardiovascular risk factors (CVRF) in obese children and adolescents.Patients and Methods: 1437 obese patients (age 9.7 (2.2–17.9) ys; 660 Mal...

hrp0089p2-p141 | Fat, Metabolism and Obesity P2 | ESPE2018

Associations between Total Leptin, Bio-inactive Leptin, Soluble Leptin Receptor and Anthropometrics in Children with Severe Early-onset Obesity (SEOO) – the German-Polish Study (EOL-GPS)

Zachurzok Agnieszka , Malecka-Tendera Ewa , Petriczko Elzbieta , Mazur Artur , Pridzun Lutz , Flehmig Bertram , Schnurbein Julia von , Ranke Michael B. , Wabitsch Martin , Brandt Stephanie

Background: Severe early-onset obesity (SEOO) in children is more frequently observed in subjects with genetic disorders of which those of leptin pathway can be analyzed biochemically and genetically.Objectives: The aim of the study was to investigate anthropometrics and leptin parameters, specifically searching for bio-inactive leptin, in children with SEOO.Methods: Study cohort includes children ...

hrp0089p2-p142 | Fat, Metabolism and Obesity P2 | ESPE2018

Children with Obesity are Taller in Early Childhood with Subsequent Catch-down Growth Until Adolescence

Kempf Elena , Vogel Tim , Kratzsch Jurgen , Vogel Mandy , Landgraf Kathrin , Sergeyev Elena , Kiess Wieland , Stanik Juraj , Korner Antje

Context: Childhood obesity is supposed to affect growth and development in children but there is uncertainty with regard to dynamics and potential causes. We analyzed differences in age-related growth patterns of obese and normal-weight children and their association with circulating endocrine and metabolic factors.Objective/Design: In a large German childhood cohort from Leipzig including 7986 children (22793 data sets) we compared cross-sectional and l...

hrp0089p2-p143 | Fat, Metabolism and Obesity P2 | ESPE2018

The Relationship between Anthropometric Measurements and Breast Milk Ghrelin and Nesfatin-1 Levels in Infants with Small for Gestational Age

Filibeli Berna Eroğlu , Karabulut Melike , Aksun Saliha , Catlı Gonul , Dundar Bumin Nuri

Introduction: It has been suggested that adipokines found in breast milk and may be effective in early growth of infants.Purpose: It was aimed to evaluate the relationship between total ghrelin (TGh) and nesfatin-1 levels in breast milk with anthropometric measurements in the first 4 months of life in infants with small for gestation age (SGA) showing fast growth pattern.Method: A total of 20 SGA and 20 control infants with appropr...

hrp0089p2-p144 | Fat, Metabolism and Obesity P2 | ESPE2018

Efficacy, Safety and Tolerability of Liraglutide, GLP-1 Analogue, in Indian Adolescent Population with Obesity

Sethi Aashish , Ramachandran Smita , Kochar Inderpal

Introduction: Liraglutide is a long-acting glucagon-like peptide-1 receptor agonist which directly stimulate POMC neurons and inhibit neuropeptide-Y and Agouti-related peptide neurons of the arcuate nucleus resulting in appetite suppression. It has been approved in adult population for obesity.Aim: To assess the Efficacy and Safety of Liraglutide in Indian Adolescent obese population.Materia...

hrp0089p2-p145 | Fat, Metabolism and Obesity P2 | ESPE2018

The Effect of Exclusive Breastfeeding and Formula Feeding on Body Composition During the First Two Years of Life

de Fluiter Kirsten , Acton Dennis , Hokken-Koelega Anita

Background: Early gain in fat mass (FM) might be influenced by type of feeding. Excessive gain in FM during the first three months of life is associated with an increased risk for adiposity and cardiovascular diseases. This three-month period is also known as the critical window for adiposity programming.Aims: To investigate differences in body composition between exclusively breastfed (BF) and formula fed (FF) infants from birth to 24 months.<p clas...

hrp0089p2-p146 | Fat, Metabolism and Obesity P2 | ESPE2018

Body Composition and Cardiovascular Function in Pre-adolescent Children of South Asian and White European Origin: Relationship to Maternal Status in Pregnancy

Whatmore Andrew , Khan Sophia , Vyas Avni , Maresh Michael , Cruickshank Kennedy , Clayton Peter

South Asian (SA), British-born adults have increased cardiovascular (CV) risk factors compared to White Europeans (WE). Early detection of CV risk may allow intervention. The Manchester HAPO (Hyperglycaemia and Adverse Pregnancy Outcomes) cohort showed babies of SA origin were born significantly shorter, lighter and had a lower mean BMI SDS than those of WE origin. We now report ethnic differences in body composition and CV markers in childhood. Measurements on 102 children (5...

hrp0089p2-p147 | Fat, Metabolism and Obesity P2 | ESPE2018

Relation Between Cardiac Function and Anthropometric Parameters in Overweight and Obese School Boys

Furdela Viktoriya , Pavlyshyn Halyna

Introduction: Approximately 42 million children under the age of five are overweight or obese worldwide. Being overweight or obese at a young age is linked to several health and economic consequences and it is, therefore, important to study causes and risk factors and identify the best prevention and treatment strategies. The result of previous epidemiological study of 277 school boys in Ternopil city demonstrated that the prevalence of overweight and obesity among pupils are ...

hrp0089p2-p148 | Fat, Metabolism and Obesity P2 | ESPE2018

Evaluation of Hydration Status of Obese Children – A Pilot Study

Akif Celik , Nurcan Cebeci Ayse

Background: Although adequate hydration is recommended for healthy nutrition, the link between less water consumption and obesity is not exactly known. It was demonstrated that less hydrated adults had a higher body mass index (BMI). Data in children are rather limited. Our aim was to compare the hydration status between obese and non-obese children.Subjects and methods: Children aged between 7 and 18 years who had a BMI over 2 standard deviation score (...

hrp0089p2-p149 | Fat, Metabolism and Obesity P2 | ESPE2018

Galanin is Positively Correlated with Insulin Resistance and Triglyceride Levels in Obese Children

Acar Sezer , Paketci Ahu , Kume Tuncay , Demir Korcan , Calan Ozlem Gursoy , Bober Ece , Abacı Ayhan

Introduction: Galanin is a neuropeptide involved in the regulation of food intake and glucose homeostasis. The objective of this study was to assess the relation of serum galanin levels with anthropometric and metabolic parameters in obese and healthy children.Material and methods: This cross-sectional study consisted of 38 obese children (mean age, 11.9±3.0 years) and 30 healthy children (mean age, 11.4±2.0 years). Clinical and biochemical [gl...

hrp0089p2-p150 | Fat, Metabolism and Obesity P2 | ESPE2018

Brown Adipose Tissue in Prepubertal Children: Associations with Sex and With the Sequence of Prenatal Growth Restraint and Postnatal Catch-up

Malpique Rita , Gallego-Escuredo Jose Miguel , Sebastiani Giorgia , Villarroya Joan , Lopez-Bermejo Abel , de Zegher Francis , Villarroya Francesc , Ibanez Lourdes

Background/objectives: Individuals born small-for-gestational age (SGA), especially those who experience postnatal catch-up growth, are at increased risk for developing endocrine-metabolic abnormalities before puberty. In adults, brown adipose tissue (BAT) has been associated with protection against metabolic disorders, such as obesity, type 2 diabetes and dyslipidaemia. Here, we assessed for the first time whether BAT activation differs between prepubertal children born SGA o...

hrp0089p2-p151 | Fat, Metabolism and Obesity P2 | ESPE2018

The Age of Pubertal Onset Correlates with Pubertal Growth Pattern and Body Weight Change in Girls

Li Yan-Hong , Du Min-Lian , Ma Hua-Mei

Background: Precocious puberty in girls may result in loss of FAH, and particularly may relates to obesity when entering adulthood. However,The influence of the timing of pubertal onset on the FAH and the change of body weight during pubertal stages is still controversial.Objective: The research is to investigate the pubertal growth pattern and the change of BMI levels in girls with ICPP and those who have normal onset of puberty but at different ages.</...

hrp0089p2-p152 | Fat, Metabolism and Obesity P2 | ESPE2018

Does Late Sleeping Time Results Increased Bedtime Snack? What is the Risk of this in Childhood Obesity?

Yılmaz Mehmet Mustafa , Gunay Fatih , İlarslan Nisa Eda Cullas , Yılmaz Ozlem , Ateş Funda Seher Ozalp , Kose Serdal Kenan , Atalay Semra , Bilir Pelin

Objective: Several studies have shown that sleep plays an important role as a modulator of metabolic homeostasis. Indeed, hundreds of studies have been published to examine the relationship between insufficient sleep, late bedtime and obesity. We have studied bedtime snack as another parameter. We suggested that it may be a risk factor for obesity. When we looked at the literature, we could not find any study about bedtime snack in childhood, but there are a few studies in adu...

hrp0089p2-p153 | Fat, Metabolism and Obesity P2 | ESPE2018

Early BMI Trajectory Classes are Linked to Distinct Body Fat Partitioning Later in Childhood

Michael Navin , Ying Ong Yi , Sadananthan Suresh Anand , Aris Izzuddin M , Tint Mya Thway , Lun Wen Yuan , Wei Pang Wei , Ling Loy See , Soh Shu-E , Shek Lynette Pei-Chi , Yap Fabian Kok Peng , Tan Kok Hian , Godfrey Keith M , Gluckman Peter D , Chong Yap Seng , Karnani Neerja , Kramer Michael S , Eriksson Johan G , Fortier Marielle V , Velan S Sendhil , Lee Yung Seng

Background: Growth patterns in infancy and early childhood have been linked to risks of obesity and cardiometabolic disorders in adulthood. Body fat partitioning, particularly increased fat accumulation at ectopic sites, has been strongly associated with cardiometabolic disorders. However, the lack of precise body composition measures in prior longitudinal birth-cohort studies has made it difficult to ascertain if early growth patterns could result in consolidation of distinct...

hrp0089p2-p154 | Fat, Metabolism and Obesity P2 | ESPE2018

Hair Cortisol Concentrations in Overweight and Obese Children and Adolescents

Genitsaridi Sofia , Karampatsou Sofia , Papageorgiou Ifigeneia , Mantzou Aimilia , Paltoglou Georgios , Kourkouti Christie , Papathanasiou Chryssanthi , Kassari Penio , Nicolaides Nicolas C , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents a major health problem of our century that has reached epidemic proportions globally during the last decades. In obese subjects, a relatively high cortisol output in urine has been observed compared to nonobese individuals. However, cortisol concentrations in blood, saliva, and urine in association with obesity have not been consistent across studies. Hair cortisol concentrations (HCC) determined in scalp hair provide...

hrp0089p2-p155 | Fat, Metabolism and Obesity P2 | ESPE2018

Associations between Body Fat Mass and Internalizing and Externalizing Behaviors and Anxiety in Children and Adolescents

Christaki Eirini , Bastaki Despoina , Valavani Eleni , Kanaka-Gantenbein Christina , Bosciero Dario , Chrousos George , Pervanidou Panagiota

Introduction: Body composition analysis is a painless, bloodless and highly informative method of assessing health indicators that can be used extensively in the pediatric population. This is particularly important granted that the prevalence of childhood obesity has been increasing at a fast pace worldwide. Increased adiposity in children and adolescents is an important issue for children’s growth and psychologic development. Assessing the psychosocial status of children...

hrp0089p2-p156 | Fat, Metabolism and Obesity P2 | ESPE2018

Pharmacotherapy and the Effects on LDL Levels and Growth in 2 Children with Severe Familial Hypercholesterolemia

Venkatesh Sreedharan Aravind , Yap KP Fabian

Background: Familial Hypercholesterolemia (FH) is an autosomal dominant disorder causing increased levels of total and LDL cholesterol (LDL-C). When onset is in early childhood, it is associated with higher risk of coronary heart disease and hence the emphasis on early identification and strict management to improve the life expectancy. Of the two types of FH, the homozygous variant is the most severe form associated with extremely high levels of LDL.Aim...

hrp0089p2-p157 | Fat, Metabolism and Obesity P2 | ESPE2018

Brown Tumors in Children on Hemodialysis

Miteva Polina , Roussinov Dimitar , Dimitrova Kremena , Shumnalieva Russka

Introduction: Secondary hyperparathyroidism is a serious and expected complication in almost every patient with chronic kidney disease (CKD). Nevertheless brown tumors formed by osteoclasts are rarely found in this subtype of patients and are extremely rare in children with CKD. The most common localizations of brown tumors are the jaw and long bones. We aimed to present three clinical cases of brown tumors in children with CKD on hemodialysis observed in a single dialysis cen...

hrp0089p2-p158 | Fat, Metabolism and Obesity P2 | ESPE2018

The Role of Fibroblast Growth Factor 21 and Irisin in the Pathogenesis of Obesity in Childhood and Adolescence

Karampatsou Sofia-Iliada , Genitsaridi Sofia-Maria , Papageorgiou Ifigeneia , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents a major health problem that reached epidemic proportions in the last decades. Obesity is characterized by an increase in the adipose tissue, which leads to chronic inflammation and release of adipokines, like Fibroblast Growth Factor 21 (FGF21). On the other hand, intense exercise results in decreased adipose tissue, which leads to the release of proteins, the myokines, like irisin. In obesity a resistance in FGF21 an...

hrp0089p2-p159 | Fat, Metabolism and Obesity P2 | ESPE2018

Serum NAMPT Levels are not Associated with Parameters of Liver Function in Children and Adolescents

Penke Melanie , Schuster Susanne , Dietz Yvonne , Garten Antje , Grafe Nico , Karlas Thomas , Wiegand Johannes , Korner Antje , Kiess Wieland

Background/Aim: Serum NAMPT (nicotinamide phosphoribosyltransferase) levels are altered in adult patients with non-alcoholic fatty liver disease (NAFLD). However, less is known about NAMPT serum levels children and adolescents and their association with parameters of liver function.Methods: Blood and anthropometric data of 416 children and adolescents who participated in the LIFE Child Study Leipzig were collected. Serum NAMPT (Adipogen) and cytokeratin-...

hrp0089p2-p160 | Fat, Metabolism and Obesity P2 | ESPE2018

Obesogenic Environment and Their Influence on Adiposity on Mexican Children and Adolescents

Lopez-Gonzalez Desiree , Wells Jonathan , Reyes-Delpech Pamela , Avila-Rosano Fatima , Ortiz-Obregon Marcela , Gomez-Mendoza Frida , Clark Patricia

Introduction: Obesity is the main public health problem in Mexico. Several factors have been described as explanations, mainly: increased sedentarism and caloric intake. Such environment has been described as “obesogenic”. The aim of this study was to describe the relationship between the components of such obesogenic environment and the adiposity of Mexican children and adolescents.Methods: We carried a population-based cross-sectional study o...

hrp0089p2-p161 | Fat, Metabolism and Obesity P2 | ESPE2018

Metabolic Alterations and Weight Status in Children at 8 Years: A Prospective Cohort Study

Riano-Galan Isolina , Fernandez-Somoano Ana , Rodriguez-Dehli Cristina , Venta Obaya Rafael , Tardon Adonina

Background: Prevalence of childhood obesity (OB) represents a major public health concern, given the tracking of body weight from childhood to adult age and obesity-related morbidity.Objective: To describe prevalence of overweight (OW) and OB in children at 8 years and investigate relationship with metabolic alterations (lipid profile and insulin resistance).Methods: 485 pregnant mothers recruited between 2004-2007 and 409 children...

hrp0089p2-p162 | Fat, Metabolism and Obesity P2 | ESPE2018

Correlation of Dietary Habits with Systolic Blood Pressure in Healthy Children

Efthymia Katsa Maria , Batsikoura Maria , Dolianiti Loukia , Vasilopoulos Vasileios , Eleni Kougioumtzi Dimoliani Dafni , Dimopoulos Ioannis , Paola Rojas Gil Andreea

Background: Pediatric hypertension is a risk factor for adult hypertension and cardiovascular disease which entails the necessity of early detection.Aim: To investigate how nutrition habits are correlated with systolic blood pressure (SBP) in health children and adolescent population.Methods: 1395 children and adolescents from Greece were enrolled to participate in the research. A specially designed questionnaire regarding to eatin...

hrp0089p2-p163 | Fat, Metabolism and Obesity P2 | ESPE2018

Evaluation of Voiding Dysfunction in Obese Children

Nur Asilturk Havva , Ozhan Bayram , Yuksel Selcuk

Obesity is a common public health problem. Secondary complications are increasing with the increase in the prevalence of obesity. Studies on the effect of obesity on the urinary system in children continue and are limited. In this study, it was aimed to evaluate the relationship between childhood obesity and lower urinary tract dysfunction (LUTD) with metabolic and anthropometric measures. 400 obese children between 6 and 18 years of age who had a body mass index ≥95 per...

hrp0089p2-p164 | Fat, Metabolism and Obesity P2 | ESPE2018

Comparison of Antropometric and Biochemical Parameters in Obese Children with or without Primary Headache

Akin Onur , Arslan Mutluay

Aim: The objective of our study was to investigate the physical examination and laboratory findings in obese children with or without primary headaches.Methods: A total of 161 children, aged 8-18, with obesity (90 female and 71 male) and primary headache, admitted to pediatric endocrinology and pediatric neurology department between 2013 and 2018 were evaluated retrospectively. Participants were divided into subgroups as with tension headache and migrain...

hrp0089p2-p165 | Fat, Metabolism and Obesity P2 | ESPE2018

The Protective Effect of Exclusive Breastfeeding for overweight/Obesity in Children with High Birth Weight

Kim Hae Soon , Lee Jung Won , Lee Myeongjee , Ha Eun-Hee , Kim Young Ju

Background and objectives: A positive association between birth weight and BMI among children and adolescents has been shown in many populations. Several studies have indicated that breastfed children have lower risk of childhood obesity. Therefore, the aim of this study was to investigate the BMI trajectory according to birth weight status and protective effect of breastfeeding on overweight/obesity prevalence in children 6 years of age.Methods: A retro...

hrp0089p2-p166 | Fat, Metabolism and Obesity P2 | ESPE2018

Determinants and Consequences of Exaggerated Adrenarche in Simple Obesity

Schepper Jean De , Vanbesien Jesse , Verheyden Stephanie , Anckaert Ellen , Gies Inge

Obese children are at risk for increased DHEAS production, which is assumed to arise from hyperinsulinemia, hyperleptinemia, increased IGF-1 production or chronic low grade inflammation. Exaggerated adrenarche is suspected to be a forerunner of polycystic ovary syndrome in girls, but its consequences in obese boys are less well studied. In this study we evaluated the presence of exaggerated adrenarche in a cohort of obese boys and girls and investigated whether obese children ...

hrp0089p2-p167 | Fat, Metabolism and Obesity P2 | ESPE2018

Metabolic Alteration in Patients Affected by PseudoHypoParathyroidismo 1a (PHP1a): A Preliminary Data

Fintini Danilo , Ubertini Graziamaria , Scire Giuseppe , Covertino Alessio , Bocchini Sarah , Deodati Annalisa , Cappa Marco

Pseudohypoparathyroidism (PHP) is a rare disease characterized by hormone resistance due to defect of the α subunit of the stimulatory G protein (Gsα). Hypocalcemia due to parathyroid hormone (PTH) resistance is common. PHP1a determined by maternal LoF mutations in GNAS, presents severe obesity as early feature with increased risk of developing metabolic derangement during life. The aim of the study was to evaluate the metabolic alteration in a population of...

hrp0089p2-p168 | Fat, Metabolism and Obesity P2 | ESPE2018

Weight Loss Outcomes in Two-Year Multidisciplinary Lifestyle Intervention Program Involving Obese Children and their Parents

Krnic Nevena , Uoic Anita Spehar , Bogdanic Ana , Kubat Katja Dumic , Pavic Eva , Putarek Natasa Rojnic

Background: Increasing prevalence of obesity requires improvement in current therapeutic approaches. Multidisciplinary lifestyle intervention programs involving both children and their parents are showing promising results.Aim: To compare the efficacy of family-based multidisciplinary program with standard weight loss counseling program in obese children.Methods: The intervention group consisted of 119 obese children with BMI 85 kg...

hrp0089p2-p169 | Fat, Metabolism and Obesity P2 | ESPE2018

Relationship between Glucose and Lipid Metabolism, Inflammatory Factors and Adipokines in Children with Obesity

Chen Ruimin , Ouyang Qian , Yuan Xin , Ai Zhuanzhuan , Cai Chunyan , Lin Xiangquan , Zhang Ying , Yang Xiaohong

Objective: To investigate the co-relationship among glucolipid metabolism and inflammation, adipokines in obese and normal weight children.Methods: Children aged 5 to 15 year-old were collected. Fasting venous blood samples were collected to test liver function, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), fasting plasma glucose (FPG) and insulin. The inflammatory marker...

hrp0089p2-p170 | Fat, Metabolism and Obesity P2 | ESPE2018

Development of Resistance to Sorafenib, a Multikinase Inhibitor, in Hepatocellular Carcinoma is Mediated by SIRT

Garten Antje , Grohmann Theresa , Barnikol-Oettler Anja , Kluckova Katharina , Lavery Gareth , Kiess Wieland , Penke Melanie

Background/aim: Sorafenib® is a multi-kinase inhibitor and one of the few systemic treatment options for patients with advanced hepatocellular carcinomas (HCCs). Resistance to Sorafenib® develops frequently and could be mediated by the NAD dependent deacetylase sirtuin (SIRT) 1, a master regulator of cellular energy metabolism and stress responses. We aimed to find out if Sorafenib® treatment depends on changes in cellular NAD le...

hrp0089p2-p171 | Fat, Metabolism and Obesity P2 | ESPE2018

Gender and Pubertal Tendencies of Plasma leptin and Dopamine Levels Depending on TaqIA DRD2 Gene Polymorphism in the Different Pediatric Obesity Classes

Viazava Liudmila , Solntsava Anzhalika , Aksionava Alena , Dashkevich Alena

Study aim was to evaluate the contribution of DRD2 gene TaqIA polymorphism, plasma leptin and dopamine concentrations to obesity development in children with different adiposity classes, depending on gender and pubertal stage.Materials and methods: 223 children aged from 11 to 17.9 years were involved in the retrospective one-stage analysis, 179 of them were randomly genotyped in the TaqIA of DRD2 gene and blood dopamine (BD) concentrations were detected...

hrp0089p2-p172 | Fat, Metabolism and Obesity P2 | ESPE2018

Iron Metabolism Disorders in Prepubertal Obese Children with and Without NAFLD

Giannini Cosimo , Polidori Nella , Primavera Marina , Bagordo Marika , Mohn Angelika , Chiarelli Francesco

Background: Childhood obesity is associated with non-alcoholic fatty liver disease (NAFLD). Previous studies in obese adult and pubertal children with NAFLD have shown that chronic inflammation/oxidative stress and insulin resistance might induce iron metabolism disorders, characterized by increased Hepcidin and Ferritin levels and decreased serum Iron levels. However, data evaluating these findings in a well selected population of obese prepubertal children are still missing....

hrp0089p2-p173 | Fat, Metabolism and Obesity P2 | ESPE2018

Familial Hypercholesterolemia Due to Homozygous LDLRAP1 Mutation: Variability of Phenotype and Response to Medical Therapy

Panou Evangelia , Schumacher Johannes , Woelfle Joachim

Background: Familial hypercholesterolemia (FH) leads to markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and is associated with a significantly increased cardiovascular mortality already in childhood and adolescence. FH is caused by dominant mutations in the genes encoding LDL-receptor (LDLR), ApoB-100 and protein convertase subtilin/kexin9 (PCSK9), whereas rarely recessive forms due to mutations in LDL receptor adaptor protein 1 (LDLRAP1...

hrp0089p2-p174 | Fat, Metabolism and Obesity P2 | ESPE2018

CAN Triponderal Mass Index be a New Indicator in the Predicting Cardiometabolic Risk in Obese Adolescents?

Cingoz Gulten , Filibeli Berna Eroğlu , Dundar Bumin Nuri , Catlı Gonul

Introduction: BMI is claimed to be unreliable in the determination of body fat rate and cardiometabolic risk. Troublesome and reproducibility low measurements like waist circumference, waist circumference/height rate are used in the evaluation of cardiometabolic risk. Triponderal mass index (TMI; weight/height3), however, is suggested to be superior BMI in determining body fat rate and obesity.Purpose: In this study TMI’s relationship wit...

hrp0089p2-p175 | Fat, Metabolism and Obesity P2 | ESPE2018

Social Networks, Social Support and Weight-Related Outcomes among Adolescents

Ybarra Marina , Yu Jennifer , Kakinami Lisa , Mathieu Marie-Eve , Henderson Melanie , Barnett Tracie

Introduction: People’s weight-related behaviors may be influenced by their personal social network (SN), notably via family and friends’ behavioral modelling and motivational social support (SS).Objective: We examined the cross-sectional relation between social network-based social support (SS) and weight-related outcomes among adolescents ina pilot study within the QUALITY cohort, a longitudinal study investigating the natural...

hrp0089p2-p176 | Fat, Metabolism and Obesity P2 | ESPE2018

Identification of A Novel Homozygous Mutation in BBS10 in Five Children With Bardet-Biedl Syndrome

Yilmaz Gulay Can , Keskin Ece , Sobu Elif

Bardet-Biedl syndrome (BBS) is a rare and multisystemic disorder characterized by rod-cone dystrophy, post-axial polydactyly, learning difficulties, renal abnormalities, obesity and hypogonadism. The disorder is genetically heterogeneous. To date, 21 genes present on different chromosomes have been mapped. The most common genes are BBS1 (locus 11q13) and BBS10 (locus 12q21.2). We aimed to report two family with five affected children with typical clinical features of Bardet-Bi...

hrp0089p2-p177 | Fat, Metabolism and Obesity P2 | ESPE2018

The Effects of the Birth Weight on the Fat Distribution and Fatness Parameters of the Body

Hatipoğlu Nihal , Direk Gul , Hepokur Merve Nur , Tatlı Zeynep Uzan , Cicek Betul , Unalan Demet , Mazıcıoğlu M. Mumtaz , Ozturk Ahmet , Kurtoğlu Selim

The weight of birth affects the weight status and fat distribution in the later period of life. It is suggested that both low and high birth weight pose a risk for cardiometabolic diseases. In this study, the effects of birth weight on body fat mass and body fat distribution parameters during childhood and adolescence period were evaluated.Method: In this cross-sectional study, 4581 children ages between 6-17 years at primary and secon...

hrp0089p2-p178 | Fat, Metabolism and Obesity P2 | ESPE2018

Oxidative Homeostasis Dysregulation May Promote Pathogenesis of Cardio-metabolic Complications in Childhood Obesity

Corica Domenico , Aversa Tommaso , Ruggeri Rosaria Maddalena , Cristani Mariateresa , Panasiti Ilenia , Luca Filippo De , Wasniewska Malgorzata

Introduction: Advanced glycation end-products (AGEs) are heterogeneous groups of irreversible adducts resulting from non-enzymatic glycation and glyoxidation of proteins, lipids, and nucleic acid. AGEs and its cell receptor RAGE have been involved in the pathophysiology of cardiovascular and metabolic diseases. Interaction of AGEs with RAGE results in an increased generation of oxygen radicals and increased expressions of pro-inflammatory cytokines. Circulating soluble AGE rec...

hrp0089p2-p179 | Fat, Metabolism and Obesity P2 | ESPE2018

Body Composition Parameters, Systemic Inflammation and Metabolic Syndrome Manifestations in Children and Adolescents

Christaki Eirini , Pervanidou Panagiota , Bastaki Despoina , Valavani Eleni , Kanaka-Gantenbein Christina , Boschiero Dario , George Chrousos

Introduction: Increased adiposity has been associated with smoldering systemic inflammation and metabolic syndrome manifestations, leading to further morbidity by increasing the risk for type 2 diabetes mellitus and cardiovascular disease in adults. Similar analyses have not been performed systematically in children and adolescents.Hypothesis: This study investigates the interrelations between body composition parameters and indices of inflammation and m...

hrp0089p2-p180 | Fat, Metabolism and Obesity P2 | ESPE2018

Relationships between Obesity Parameters and Urinary Concentrations of Phthalates and Phenols in Korean Girls

Kim Shin-Hye , Choi Man Ho , Hong Youngmin , Park Mi-Jung

Background: Humans are exposed to a variety of endocrine disruptors (EDs), including phthalates and phenol substitutes, in daily life. Previous studies have suggested the association between individual EDs and the risk of obesity, however, studies on the effects of multiple EDs have been extremely limited. We investigated the associations of urinary 12 phthalates, 3 polycyclic aromatic hydrocarbons, and 26 phenol substitutes with adiposity measures in Korean girls.<p class...