ESPE Abstracts

Introduction: Dichotomous nature of current definition of metabolic syndrome (MS) in youth results in loss of information. On the other hand, the complex calculation of continuous MS scores using standardized residuals in linear regression (Z scores) or factor scores of principal component analysis (PCA) is demanding and highly impractical for clinical use. Recently, a novel, easily calculated continuous MS score called Pediatric siMS score (PsiMS score) was developed based on the IDF MS criteria for the pediatric population. Database including data on 153 obese children and adolescents was used for score development. Results showed that PsiMS score calculated using formula: (2xWaist/Height) + (Glucose(mmol/l)/5.6)+ (triglycerides(mmol/l)/1.7)+ (Systolic BP/130)−(HDL(mmol/l)/1.02) showed high correlation with most of the complex continuous scores calculated using sum of Z scores or factor scores of PCA (0.792–0.901). Complex metabolic syndrome scores require advanced statistical software, limiting their use in everyday clinical practice. The development of PsiMS score overcomes these issues, since it correlates highly with complex scores, while being simple and easy to calculate. Also, PsiMS score is not sample specific, meaning that scores from different studies can be compared, as well as changes in score of a single patient.

Objective: To demonstrate the usefulness of PsiMS score calculation in research and everyday clinical practice.

Method: Examples of different clinical scenarios, including significant changes in cardiometabolic risk factors in individual obese subjects with metabolic syndrome will be presented, illustrating the benefits of easily quantifying metabolic syndrome in everyday clinical setting for both patients and physicians.

Conclusion: PsiMS score represents a practical and accurate score for quantification and evaluation of MS in the obese youth.