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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

Poster Presentations

Pituitary, Neuroendocrinology and Puberty P3

hrp0089p3-p284 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Infant with Osteogenesis Imperfecta and Panhypopituitarism: A Case Report

Arliena Amin , Zaini Azriyanti Anuar

Background: Osteogenesis imperfecta (OI) is a genetic disorder mostly associated with mutation in one of the two genes encoding a chains of collagen type 1 (COL1A1 and COL1A2). Severity of the symptoms varies widely, caused by increase bone fragility and low bone mass. However, there is no direct relation reported in osteogenesis imperfecta and panhypopituitarism.Clinical case: Nineteen months old boy was clinically diagnosed with osteogenesis i...

hrp0089p3-p285 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Panhypopituitarism with Tall Stature Diagnosed in a 20 Years Old Boy

Forrester Andrea , Cecchi Griselda , Perez Guadalupe , Soria Luciana , Masllorens Francisca , Juarez Sofia , Vallone P.M. Constanza , Grassi Magdalena

Background: Growth hormone plays a primary role in stimulating postnatal growth by way of insulin-like growth factor 1 (IGF1) which is produced in the liver in response to GH. A deficiency of GH arrests maturation during childhood, and the stature of such subjects is generally much shorter than the average stature. However, some cases of GH deficiency attain normal stature as adults.Case presentation: A 20 years old man was referred for a further evaluat...

hrp0089p3-p286 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Post-Traumatic Hypopituitarism Caused by Pituitary Stalk Transection

Ruszała Anna , Wojcik Małgorzata , Krystynowicz Andrzej , Wyrobek Łukasz , Starzyk Jerzy B

Common cause of hypopituitarism is congenital, genetically determined abnormality called pituitary stalk interruption syndrome (PSIS). It is characterised by hypoplastic anterior pituitary gland with thin or absent infundibulum and ectopic posterior pituitary location in MRI examination. Post-traumatic hypopituitarism may mimic this image. We present 7 years and 10 months old girl who was admitted to Pediatrics Institute due to hypoglycemia during an acute gastroenteritis. Hyp...

hrp0089p3-p287 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Invasive Macroprolactinoma with Cabergoline Induced Cerebrospinal Fluid Rhinorrhoea in Childhood

Dastamani Antonia , Ederies Ashraf , Aquilina Kristian , Dorward Neil , Korbonits Marta , Spoudeas Helen

Background: Nonsurgical development of nasal cerebrospinal fluid (CSF) leaks may occur in the setting of pituitary adenomas, especially following a favorable response of invasive prolactinomas to initiation of Dopamine Agonist (DA) therapy, but this has not previously described in children.Case description: A girl of Srilankan origin, aged 13.8 years, whose parents spoke no English, presented with headaches and secondary amenorrhea. Pituitary MRI reveale...

hrp0089p3-p288 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Bilateral Optic Nerve Hypoplasia Revealing Septo Optic Dysplasia or De Morsier Syndrome: A Case Report

Yamina Aribi , Meriem Bensaleh , Lila Brakni , Zoubir Sellal , Aicha Lachkhem , Samia Ouldkablia

Background: Septo-optic dysplasia (SOD) is a congenital affection characterized by classic triade: optic nerve hypoplasia, hypothalamic-pituitary endocrine deficits and mdline abnormalities of the brain. It is typically diagnosed in infancy and has a variable presentation.Case presentation: The patient is an 5 year old Algerian girl. At birth, bilateral congenital nystagmus and strabism was noted? Right blindness was suspected by parents at age of 2 year...

hrp0089p3-p289 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Investigating Malnutrition Among Children Diagnosed with Neuroendocrine Tumors Receiving Chemotherapy in a Tertiary Care Hospital of Pakistan

Fatima Arooj , Zaidi Syed Sammar Abbas

Background: Children under 25 diagnosed with neuroendocrine tumors often suffer from Malnutrition which raises the risk of infections. Being immunocompromised, there is a marked reduction on quality of life (QoL) and health outcome. Malnutrition also enhances the incidence of postoperative complications such as delayed wound healing, wound dehiscence, morbidities and mortalities.Aims: To investigate malnutrition among children diagnose with neuroendocrin...

hrp0089p3-p290 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

An Interesting Etiology in Childhood Central Diabetes Insipidus HIBERNOMA

Ergur Ayca Torel , Aslan Ayla , Canhilal Ece

Introduction: Central Diabetes Insipitus (CDI) results from the inability to secrete ADH secreted by the neurohypophysis system to control water-electrolyte metabolism. In the etiology of CDI many congenital and acquired CNS tumors, infiltrative diseases,infections, autoimmune events, head trauma and idiopathic can be responsible. In this article, a child case with CDI due to intracranial occurence which is very rare in etiology is presented and the approach and follow up are ...

hrp0089p3-p291 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Neonatal Panhypopituitarism with Hypoglycemia, Edema, Inspiratory Stridor and Cholestasis

Momm Benita , Nitsch Alexander , Hammer Elke

We report the case of a female newborn, first child of healthy, non-consanguineous parents, born at 42+0 weeks of gestation, who was admitted 21 h after birth with severe hypoglycemia, hypothermia, decreased muscle tone, inspiratory stridor and edema. The course included poor feeding and failure to thrive, hyperbilirubinemia and cholestasis. Infectious or metabolic diseases were ruled out by clinical and laboratory investigations. Hormonal evaluation confirmed the diagnosis of...

hrp0089p3-p292 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

MRI Changes in Time after Cranial Irradiation, and their Relation with Pituitary Function in Survivors of Childhood Medulloblastoma

van Ommen CCN , van Iersel L , Lequin MH , Clement SC , Janssens GOR , Boot AM , Caron HN , Claahsen-van der Grinten HL , Granzen B , Han KS , Michiels E M , van Trotsenburg ASP , Vandertop WP , van Vuurden DG , Kremer LCM , Schouten-van Meeteren AYN , van Santen HM

Background: Hypothalamic-pituitary (HP) deficiencies are frequent in childhood brain tumor survivors (CBTS) after cranial radiation. There is currently no consensus on the most optimal way to screen for HP dysfunction regarding diagnostic tests or time interval. It is not known whether MRI changes in time in the HP-region or in brain volume are predictive of HP dysfunction.Aim: To quantify changes in the HP-region and in brain volume on MRI in CBTS after...

hrp0089p3-p293 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Two Identical Twins … But not in Everything. A Difficult Diagnosis

Damia Chiara Maria , Gallo Dario , Partenope Cristina , Pitea Marco , Fioretti Lorenzo , Adavastro Marta , Pajno Roberta , Weber Giovanna , Barera Graziano

GR and GT are diamniotic monochorial preterm twins (32 GA), both AGA (GR: W -1 SDS, L -1.5 SDS; GT: W and L 0 SDS), with normal karyotype and array-CGH on amniotic fluid, with no major complications associated to prematurity. At birth GT presented bilaterally cryptorchidism associated with micropenis, GR presented normal male genitalia. In the first year of life a severe growth deceleration in length (from -3SDS to -5 SDS) was observed, mainly after six months of life in both ...

hrp0089p3-p294 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Growth Hormone Deficit Associated to Complex Arteriovenous Malformation – Case Report

Mogoi Mirela , Velea Puiu Iulian , Paul Corina

Background: Arteriovenous malformations (AVMs) are rare in kids, estimated to represent 3% of all AVMs. They tend to rupture more frequently than in adults and, usually, are brought to attention after rupture, as the most common non-traumatic intracerebral hemorrhage. AVMs could also present with recurrent seizures or headaches. Their optimal management remains controversial.Case report: We present the case of a 4.5 y old boy, presented in our department...

hrp0089p3-p295 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Does Acquired Hypothyroidism Lead to Precocious Puberty?

Aydın Dilek , İşguven Pınar , Aydın Engin

Introduction: Hypothyroidism without treatment usually leads to delayed puberty in pediatric patients, sometimes it may rarely lead Van Wyk Grumbach syndrome (VWGS) which is characterized by isosexual precocious puberty. Exact mechanism of VWSG is unknown. High thyroid stimulating hormone (TSH) levels may directly effect on follicular stimulating hormone (FSH) receptors and lead precocious puberty. Interestingly simple thyroid hormone replacement therapy resolves symptoms in t...

hrp0089p3-p296 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Analysis of Influencing Factors on Bone Maturation in Girls with Central Precocious Puberty (CPP)

Lee Gi-Min , Moon Jung-Eun , Lee Su-Jeong , Kim Hyeon-A , Ko Cheol-Woo

Background & objective: The occurrence of CPP seems to be increasing in our clinical practice thesedays. It is known that CPP causes socio-psychological disturbances relating to early pubertal changes and finally leads to a significant decrease in the final adult height because of premature closure of the growth plate. This study was conducted to see major factors affecting to the bone maturation, which is closely related to the final adult height in girls with CPP.<p ...

hrp0089p3-p297 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Is Prematüre Adrenarch Associated with Precocıous Puberty via Kisspeptin?

Albayrak Aysun , Direk Gul , Uzan Tatlı Zeynep , Nur Hepokur Merve , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Aim: Premature pubarche is defined as the start of axillary and pubic hair before age 9 in boys and 8 in girls. 10 times more common in girls than boys. Central precocious puberty is a condition due to early activation of hypothalamic-pituitary- gonadal axis associated with breast development before age 8 in girls and testicular volume growth before age 9 in boys. Despite this axle is not known exactly which hormones are respnsible for the activation, the role of kisspeptin&#1...

hrp0089p3-p298 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Distinct Presentations of McCune Albright Syndrome, Report of Two Cases

Yesiltepe Mutlu Gul , Kabataş Eryilmaz Sema , Ceylaner Serdar , Hatun Sukru

McCune-Albright Syndrome is a rare genetic disorder characterized by triad of polyostotic fibrous dysplasia of bone, precocious puberty and café au lait skin pigmentation. It is resulted from an activating mutation in the GNAS gene encoding the alpha subunitof stimulatory G protein. Here we present two cases with McCune Albright syndrome presenting with different clinical findings.Case 1: A 7-year and 6 month-old girl presented with breast ...

hrp0089p3-p299 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

A Case of Atypical McCune-Albright Syndrome with Vaginal Bleeding

Adji Tjahjono Harjoedi

Background: McCune-Albright syndrome (MAS) is a rare, heterogenous, clinical condition caused by a rare genetic mutation. The disorder is more common in females and is characterized by a triad of cutaneous, bone and endocrine abnormalities.Case Presentation: We report a girl with MAS, presenting initially with vaginal bleeding at the age of 12 months. Ultrasonography revealed bilateral ovarian cysts and ureteral and ovarian enlargement. Bone age rapidly ...

hrp0089p3-p300 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Evaluation of Cases with Pubertal Gynecomastia

Nur Peltek Kendirci Havva , Demir Emre

Introduction and Aim: Pubertal gynecomastia is the transient proliferation of glandular tissue in breasts of men without any endocrin pathology. Relatively higher levels of estrogen than plasma testosteron levels and imbalance between tissue estrogen and testosteron levels are considered to be important in pathogenesis. In this study it is aimed to determine the clinical and laboratory properties of our patients who were diagnosed as pubertal gynecomastia and compare with heal...

hrp0089p3-p301 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

A Case of Central Diabetes Insipidus Developed 4 Years after the Non-CNS-Risk Unifocal Bone Lesion of Langerhans Cell Histiocytosis

Nakatani Hisae , Miyai Kentaro , Takasawa Kei , Kashimada Kenichi , Morimoto Akira , Nagasawa Masayuki , Oshiba Akihiro

Background: Langerhans cell histiocytosis (LCH) is a rare disease with an incidence of less than 10 per million, and characterized by the clonal proliferation of pathogenic Langerhans cells. The clinical courses are diverse, ranging from spontaneously remitting single organ disease to life-threatening multisystem involvement. One of the serious complications of LCH is diabetes insipidus (DI), and patients with CNS-risk lesions had higher cumulative incidence of DI. On the othe...

hrp0089p3-p302 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Effect of Triptoreline in Patients with Central Precocious Puberty at Children’s Hospital 1, Ho Chi Minh City, Vietnam

Huynh Loan , Tran Huyen

Precocious puberty is defined by the development of secondary sexual characteristics before the age of 8 in girls and before the age of 9 in boys. If not diagnosed and treated at an early stage, precocious puberty can compromise final adult height and trigger psychological disturbances. Gonadotropin- releasing hormone analogs (GnRHa) contributes to achievement of target final height by reducing the acceleration of bone maturation.Objectives: To analyze c...

hrp0089p3-p303 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Morning Basal Luteinizing Hormone, A Good Screening Tool for Diagnosing Central Precocious Puberty

Hyuk Jung In , Min Lee Dong

Background: The current standard method to diagnose central precocious puberty(CPP) is gonadotropin releasing hormone stimulation test (GnRHST). But, it is inconvenient for children because of time-consuming and multiple samples. This study aimed to present utility of morning basal luteinizing hormone (LH) for the screening of central precocious puberty with emphasis on the influence of diurnal variation.Methods: This study is a retrospective review of 1...

hrp0089p3-p304 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

A 2-Year-Old Boy with Epiphysis Tumor and Precocious Puberty

Osokina Irina

Epiphysis inhibits formation and secretion of the most pituitary hormones and at the first turn gonadotropins. Frequency of epiphysis tumors, pinealomas in children is 2.5% of all verified tumors of brain. 75% of epiphysis tumors are malignant. Endocrinological disturbances can be the first signs of pinealoma. In 10% cases there is precocious puberty syndrome. A 2.5 year-old boy presented to the endocrinology department with an 16-month history of accelerated physical developm...

hrp0089p3-p305 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Central Precocious Puberty as a Result of Hypotalamus Hamartoma

Osokina Irina

Presentation of case: A 3-year-old boy with central precocious puberty as a result of the organic lesion of brain (hamartoma of hypotalamus). Complains.Increased height velocity, masculinization, fast growth of external genitalia, frequent erections, acne, low voice. Medical history. The baby was born with weight 3400 g. The age of the mother at birth of the child was 23 years. The breast feeding 6 months. In the age of 24 months boy started to grow very fastly. In the age of ...

hrp0089p3-p306 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Precocious Puberty as a Result of Ectopic Hormone-Producing Tumor

Osokina Irina

Ectopic hormone products are typical for cancerous cells. Cancerous cells can produce ACTH, lipotropin, alfa-melanocytostimulating hormone, beta-endorfin, vasopressin, oxytocin, insuline, glucagon, gastrin, secretin, VIP, calcitonin, hypothalamic releasing-hormones, prolactin, parathyroid hormone, growth hormone, chorionic gonadotropin, growth factors. In the majority of ectopic hormone-producing tumor cases clinical symptoms are absent. This is explained by the fact that tumo...

hrp0089p3-p307 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Premature Adrenarche and Pseudohypoparathyroidism – Mechanistically Linked or Coincidence?

Odone Jessica , Yadlapalli Kumar , Burren Christine

Aims: To describe a case of premature adrenarche with pseudohypoparathyroidism, an as yet unreported combination.Case: An otherwise well 8 year old girl presented to a Paediatric Endocrine Clinic with early pubic hair development suggestive of Premature Adrenarche. Blood tests revealed hypocalcaemia, elevated phosphate and highly elevated parathyroid hormone (PTH) level, giving a biochemical diagnosis of pseudohypoparathyroidism. She had normal stature (...

hrp0089p3-p308 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Efficacy of Ziyin Xiehuo Granules and Zishen Qinggan Granules in girls with Partial Precocious Puberty: A Multicenter, Randomized, Single-Blinded, Controlled Trial

Sun Wen , Han Xinhui , Yu Jian , Wang Yonghong , Yan Weili

Objective: To evaluate the effect of Ziyin Xiehuo granules (ZYXH) and Zishen Qinggan granules (ZQ7G) on partial precocious puberty (PPP).Methods: The present study was a multicenter, randomized, single-blinded, positive-controlled trial. A total of 143 patients were assigned to either the ZYXH group or the ZQ7G group using a random number table. The ZYXH group received ZYXH three times daily for 6 months, while the ZQ7G group received ZQ7G three times da...

hrp0089p3-p309 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

GLP-1 Receptor Agonist in a Patient with Craniopharyngioma-Related Obesity

Antoniou Maria-Christina , Diaz-Escagedo Patricia , Bouthors Therese , Elowe-Gruau Eglantine , Stoppa-Vaucher Sophie , Messerer Mahmoud , Hauschild Michael

Introduction: Glucagon-like peptide 1 (GLP-1) receptor agonists have been successfully used in adults with hypothalamic obesity, showing a BMI decrease and metabolic profile improvement. Data on GLP-1 receptor agonist treatment for children and adolescents is limited. Herein, we present a clinical case of a male adolescent treated with GLP-1 receptor agonist for hypothalamic obesity, secondary to craniopharyngioma.Case report: A 15.8 year-old boy (Height...

hrp0089p3-p310 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Poland’s Syndrome and Hypogonadotropic Hypogonadism

Stancampiano Marianna Rita , Meroni Silvia Laura Carla , Lascio Alessandra Di , Gianninoto Moira , Russo Gianni

Poland’s syndrome is characterised by unilateral absence or hypoplasia of the pectoralis muscle, associated with the ipsilateral malformation of the hand. The syndrome is usually sporadic and occurs in about 1:32.000 live births. Poland’s syndrome has been described associated with other abnormalities, including renal aplasia or hypoplasia, hemivertebra, Klippel-Feil syndrome and Moebius’ syndrome. In literature are reported six cases of Moebius syndrome associa...

hrp0089p3-p311 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Congenital Hypopituitarism Associated with Complex Cranio-Vertebral Junction Anomalies

Valenzise Mariella , Pitrolo Elda , Biasi Michele , Santucci Simona , Wasniewska Malgorzata , Luca Filippo De

Background: Abnormalities of cervical spine have been described in association with pituitary anomalies in the context of malformative syndromes with midline defects. Several genes are involved in the control of pituitary gland development, differentiation and function. In particular, the presence of os odontoideum has been reported in one case of pituitary hypoplasia, associated with leg anomalies, renal dysplasia and no aberrations of the BMP4, BMP2 and PTX1 genes. In anothe...

hrp0089p3-p312 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Premature Thelarche Followed by Acute Lymphoblastic Leukemia in a 1.5 Year Old Girl

Krstevska-Konstantinova Marina , Stamatova Ana , Kuzevska-Maneva Konstandina , Kocheva Svetlana , Conevska Biljana , Martinova Kata , Jovanovska Aleksandra

Introduction: Premature thelarche is considered a benign condition of breast development in prepubertal girls. It usually resolves after a certain period of time.Materials and methods: A 1.5 year old girl was referred to the pediatric Endocrinology department due to breast development which appeared two months prior to the visit.Results: Upon clinical examination the patient had Tanner breast stage M2-3 bilaterally, but otherwise a...

hrp0089p3-p313 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Two Cases of Non-syndromic Congenital Unilateral Hypoplasia in One Family

Stamatova Ana , Kuzevska-Maneva Konstandina , Sukareva-Angelovska Elena , Gucev Zoran , Tasic Velibor , Hofele Julija , Krstevska-Konstantinova Marina

Introduction: Micromastia or breast hypoplasia is a condition which is described as postpubertal underdevelopment of a woman’s mammary tissue. Breast hypoplasia may be congenital or acquired. The defect can be isolated or associated with other pathology, including syndromes and chest wall anomalies, it can also be unilateral or bilateral. Unilateral congenital breast hypoplasia is a rare anomaly of breast development, whose incidence is unclear.Meth...

hrp0089p3-p314 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Klinefelter Syndrome with Ambiguous Genitalia in a Child

Faizi Muhammad , Rochmah Nur , Purwana Arie

Background: Klinefelter Syndrome (KS) is the most common sex chromosome disorder in males caused by additional X chromosome. It is characterized by progressive testicular failure. KS patient usually have complete male sexual differentiation without genital ambiguity. The prevalence of KS is 1 in 660 males which only 10% are detected before or during puberty, and about two third so fall men with X-chromosome polyploidies fail to be identified during their lifetime.<p class=...

hrp0089p3-p315 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

The Change in Growth’s Velocity in Patients with Premature Puberty Receiving Treatment with Analogues of Lyuliberin

Berseneva Olga , Bashnina Elena , Turkunova Mariia

Background: Suppression of hypothalamic-pituitary-gonadal system activity by luliberin analogues in premature sexual development of the central genesis is accompanied by a decrease in growth’s velocity, sexual development and progression of bone age.Aim: Study of the effectiveness of gonadotropin-releasing hormone agonist therapy, their influence on the physical developmentMethods: 66 patients were treated by triptorelin. Idio...

hrp0089p3-p316 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

The Efficacy of Treatment in Vietnamese Children with Central Precocious Puberty

Tuong Vy Vo , Huy Luan Nguyen , Vu Quynh Huynh Thi

Background: Central Precocious Puberty (CPP) may be lead to consequences such as limitation adult stature, sexual abuse, and emotional distress. GnRH agonist therapy in patients with CPP has been demonstrated in increasing adult height and improving emotional distress in puberty stage.Objective: Evaluating the efficacy of treatment in patients with central precocious puberty after one year in Children Hospital 2, Vietnam in 7 years, from 01/2017 to 12/20...

hrp0089p3-p317 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

The Characteristics of Central Precocious Puberty at Children’s Hospital 2 in Vietnam

Vu Quynh Huynh Thi , Le An Pham , Minh Hong Nguyen Thi , Huy Tru Vu

Objectives: To describe the characteristics of central precocious puberty in patients at Children’s Hospital 2, Vietnam from 1/2010 to 12/2016.Method: Cross – sectional analysis.Results: There were 504 cases of central precocious puberty. The mean age was 7.6±1.4 years old; most of them were females (females/males: 71/1). The rate of overweight or obesity was 52.4%, accelerated height was recorded in 64.2%. The most ...

hrp0089p3-p318 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

SIG (Special Interest Group)-ENDOPED/RUTE (Brazil): Seven Years Integrating Pediatric Endocrinology Centers throughout the Country

Arrais Ricardo Fernando , Alves Cresio Aragao Dantas , Junior Gil Guerra , Castro Luiz Claudio Goncalves , Filho Geraldo Miranda Graca , Kopacek Cristiane , Damiani Durval , Junior Raphael Del Roio Liberatore , Punales Marcia Khaled

Introduction: Telemedicine, or the use of CIT (Communication and Information Technology) to deliver and/or share medical remote assistance and knowledge, is of paramount importance, mainly in large countries, with social and economic disparities, as Brazil, by means of teleconferences, webconferences, webcasts and use of a wide range of interactive technologies, helping activities of assistance and professional health education. One of the activities provided by our RUTE (Univ...

hrp0089p3-p319 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

The Relationship Between Prolactin and Development of Puberty in Girls with Early Breast Development

Lee Seong Yong

Background: Prolactin (PRL) stimulates mammary glands and milk production in adult women. Also, high PRL level causes gonadal dysfunction by suppression of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH).Purpose: The aim of this study was to evaluate, if any, the relationship between PRL level and development of puberty in girls with precocious breast development.Methods: One hundred and ten girls with onset of b...

hrp0089p3-p320 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Central Precocious Puberty Appeared in Infancy Period in a Patient of Sotos Syndrome

Cetin Tuğba , Ceylaner Serdar , Şıklar Zeynep , Berberoğlu Merih

Background: Sotos syndrome is a rare syndrome; with distinctive clinical findings include typical facial appearance, learning disability; and overgrowth. Advanced bone age can be detected in some cases while precocious puberty reported only in two cases until now.Case: A 6,5 months of age male infant admitted to clinic with neuromotor delay and macrogenitalia. He was second child of unrelated healthy parents, and birth-weight was 4200 g. In physical exa...

hrp0089p3-p418 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Clinical and Endocrinological Manifestations of Partial Ectopic Posterior Pituitary: A New Imaging Entity

Ybarra Marina , Hafiz Rawan , Robinson Marie-Eve , Oettingen Julia von , Bui Helen , Saint-Martin Christine

Objective: To describe six cases of possible partial ectopic posterior pituitary gland (PEPP) seen on head magnetic resonance imaging (MRI) and their associated clinical and endocrinological manifestations.Methods: This is a single-center case series, from a tertiary public university health center in Montreal, Canada. Cases of children with possible PEPP were selected prospectively from 2005 to 2017, based on head MRI findings. Medical history, exam fi...