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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

hrp0089p2-p376 | Thyroid P2 | ESPE2018

Long Term Monitoring of Graves Disease in Children and Adolescents: Single Center Experience

Tunc Selma , Koprulu Ozge , Ortac Hatice , Nalbantoğlu Ozlem , Dizdarer Ceyhun , Demir Korcan , Ozkan Behzat

Introduction: Antithyroid Drugs (ATD) are generally preferred at the onset of treatment with no consensus on the duration of ATD (propylthiouracil, methymasole) treatment Graves disease in children.Objective: Examining the effectiveness of ATD treatment on children and adolescents and determining the risk factors of remission and relapse.Method: A total of 45 cases with ages varying between 1–18 years diagnosed with Graves dis...

hrp0089p2-p377 | Thyroid P2 | ESPE2018

Effects of Thyroid Autoimmunity on Non-Alcoholic Fatty Liver Disease in Euthyroid Girls with Hashimoto’s Thyroiditis

İşguven Pınar , Ersavaş Dilek , Ersavaş Mehmet , Elmas Bahri

Introduction and Aim: The aim of this study was to investigate whether autoimmune Hashimoto’s thyroiditis (HT) increases the incidence of non-alcoholic fatty liver disease (NAFLD). In addition, the relationship between autoimmunity and the following factors was evaluated: Body Mass Index (BMI), body parameters measured by Bioelectric Impedance Analysis (BIA), and metabolic syndrome parameters.Methods: 43 newly diagnosed euthyroid girls with HT (14.4...

hrp0089p2-p378 | Thyroid P2 | ESPE2018

The Prevalence of Clinically Significant Anti-TPO Positivity in Children with HLA-Conferred Susceptibility to Type 1 Diabetes

Saare Liisa , Peet Aleksandr , Tillmann Vallo

Background: The increased prevalence of anti-thyroid peroxidase antibodies (anti-TPO) and autoimmune thyroiditis in children with type 1 diabetes (T1D) has been previously well described. However, the necessity for screening for anti-TPO in children who have not been diagnosed with T1D yet, but have a HLA-conferred susceptibility to T1D, has not been reported. A 3% prevalence of anti-TPO in healthy children has been shown in studies using a cut-off value of >100 kU/L for c...

hrp0089p2-p379 | Thyroid P2 | ESPE2018

Encephalopathy Associated with Autoimmune Thyroid Disease: A Case Report

Lantigua Hector , Yafi Michael

Background: Encephalopathy associated with autoimmune thyroid disease (EAATD) is very rare in pediatrics. Contributing factors include: Sudden change is thyroid levels, cerebral vasculitis,endothelial inflammation or immune complex deposition, global cerebral hypoperfusion, as well as cerebral tissue-specific autoimmunity.The case: A 16-year-old female was diagnosed with hyperthyroidism and treated with Radio Iodine Ablation (RIA). Her total T4 level was...

hrp0089p2-p380 | Thyroid P2 | ESPE2018

Celiac Disease Screening Should be Routinely Offered in Pediatric Population with Autoimmune Thyroid Disease

Resta Maria , Triantafyllou Panagiota , Agakidis Charalampos , Maliachova Olga , Christoforidis Athanasios

Background and Hypothesis: Autoimmune thyroid disorders (AITD), including Hashimoto’s Thyroiditis (HT) and Grave’s disease (GD), are known to cluster with other autoimmune disorders (AID). There seem to exist both a pathophysiological basis of immunomodulator genes and epidemiological indications of a higher prevalence of AID including Celiac disease (CeD) in patients with AITD, compared to that in the healthy pediatric population. CeD is asymptomatic in a large prop...

hrp0089p2-p381 | Thyroid P2 | ESPE2018

Autoimmune Thyroiditis in Klippel-Feil Syndrome with Arnold Chiari and Syringomyelia

Guidoni Elisa , Lotti Federica , Geronzi Ursula , Arianna Sorrentino Laura , Municchi Giovanna

Introduction: Klippel-Feil Syndrome (KFS), prevalence of 1:40000, is characterized by congenital fusion of cervical vertebrae; three major features are short neck, low hairline at the back of the head and a limited range of motion in the neck. The phenotypic expression is variable, presenting with other vertebral abnormalities (congenital high scapula, scoliosis, kyphosis, spina bifida, hemivertebrae) or extra skeletal symptoms such us deafness, renal, heart or neurological ab...

hrp0089p2-p382 | Thyroid P2 | ESPE2018

Neonatal Monitoring of Newborns Born from Mothers with Graves’ Disease: Results of a Retrospective Monocentric Study

Dumaine Cecile , Crepon Sophie Guilmin , Pages Justine , Chevenne Didier , Rosenblatt Jonathan , Storey Caroline , Martinerie Laetitia , Carel Jean-Claude , Zenaty Delphine , Leger Juliane , Simon Dominique

Background: Neonates born from mothers with Graves’ disease are at risk to develop hyperthyroidism due to placental transmission of TSH-receptor antibodies. Neonatal hyperthyroidism should be effectively diagnosed and treated to prevent severe complications of this disease (cardiac symptoms, poor weight gain, severe neurological manifestations).Objectives: To describe the post-natal follow-up of neonates born from women with Graves’ disease.</p...

hrp0089p2-p383 | Thyroid P2 | ESPE2018

A Successful Switch Experience from High-dose PTU to MMI on Day 4 of Graves’ Thyroid Storm in a 14-Year-Old Girl

Shinohara Hiroyuki , Iwabuchi Atsushi , Yamada Akiko , Kai Tomomi , Kamoda Tomohiro

Background: The standard pharmacological treatment strategy of thyroid storm according to 2016 Japan Society of Pediatric Endocrinology Guideline. Although thiamazole (MMI) is recommended be used as the first choice in Graves’ disease, the effect of propylthiouracil (PTU) to block the conversion from T4 to T3 in peripheral tissues encourages clinicians to use against thyroid storm in its very early phase, and switch to MMI later. Nevertheless, the optimal timing of the sw...

hrp0089p2-p384 | Thyroid P2 | ESPE2018

Graves’s Disease During Pregnancy: The Impact on the Fetus and the Newborn

Belin Florine , Rodrigue Danielle , Claire Claire , Bouvattier , Teinturier Cecile , Fouati Khadidja , Linglart Agnes , Lambert Anne-Sophie

Introduction: Graves’s disease is frequent in women, its prevalence being 0.5–2% and its incidence 0.1–1% during pregnancy. Both TSH anti-receptor antibodies and the synthetic antithyroid drugs cross the placenta, increasing the risk of hypo- and/or hyperhtyroidism. Our objective is to describe the thyroid status of fetus and newborns from women with Graves’s disease referred to our Department.Materials and methods: We included childr...

hrp0089p2-p385 | Thyroid P2 | ESPE2018

Thyroid Hormone Receptor β (THRB) Mutation: Two New Cases of Heterozygous Mutation with Significant Family History

Blackburn James , Senniappan Senthil , Giri Dinesh

Introduction: Resistance to thyroid hormone (RTH) is a relatively uncommon disorder that is usually associated with mutations in thyroid hormone receptor (THR) beta, although rarely THR alpha mutations have been described. RTH beta (RTHB) is often inherited in an autosomal dominant pattern. We describe two cases of RTHB to highlight the significant variations in both clinical presentation and family history.Case 1: A 2 year old patient ...

hrp0089p2-p386 | Thyroid P2 | ESPE2018

Triac Treatment Response to Thyroid Hormone Resistantance

Cinaz Peyami , Uğurlu Aylin Kılınc , Doğer Esra , Akbaş Emine Demet , Bideci Aysun , Camurdan Orhun

Aim: Resistance to thyroid hormone (RTH) is a disease characterized by decreased sensitivity to thyroid hormone in the peripheral tissues such as cell membrane, metabolism, or nuclear receptor. In THRB gene mutation induced RTH, the effect of T3 on TRβ mutant receptors in the liver and the pituitary decreased, on TRα receptors located in the brain and heart increased. Triac’s activity is similar to T3.Case: A 1-month-old girl patient was a...

hrp0089p2-p387 | Thyroid P2 | ESPE2018

Phenotype and Genotype of Four Patients with Thyroid Hormone Resistance Syndrome due to Mutations in the THRB Gene

Toumba Meropi , Neocleous Vassos , Fanis Pavlos , Skordis Nicos , Phylactou Leonidas A , Tanteles George A , Kyriakidou-Himonas Marinella , Picolos Michalis

Background: Resistance to thyroid hormone (RTH) is a dominantly inherited rare disorder (1:40000) mainly due to mutations in the THRB gene that lead to a decreased end-organ responsiveness to thyroid hormone. Clinical and molecular characteristics of four patients with RTH are described.Patients and methods: Four patients from three non-related families were studied; two boys (8.3 and 9.2 years old) and 2 adults (35 year old male and 27 year old...

hrp0089p2-p388 | Thyroid P2 | ESPE2018

Clinical Course in a Girl with Two hTPO Mutations – Homozygous c.1268G>A (p.Gly393Arg) and Heterozygous c.208C>G (p.Ala70Pro): 27 Years of Follow Up

Stoeva Iva , Mihova Kalina , Koleva Reni , Zheliaskov Mitko , Stoilov Boris , Kaneva Radka

Of the several genetic defects responsible for thyroid dyshormonogenesis, mutations in TPO gene are the most prevalent causes of inherited defects in CH. Prevalent mutations are in exons 8-11 (catalytic site).Case presentation: Girl, born at 16d after term, before the introduction of the neonatal screening, with asphyxia, BL 55 cm, BW 4 kg. Because of insufficient weight gain, feeding difficulties, prolonged jaundice she was referred to a pediatric endoc...

hrp0089p2-p389 | Thyroid P2 | ESPE2018

A Neurological Disease Mimicking Central Hypothyroidism: MCT8 Deficiency

Demirbas Ozgecan , Eren Erdal , Tarim Omer

Introduction: Monocarboxylate transporter 8 (MCT8) is necessary for the transport of T3 to neurons. The case presented here is a male infant with neuromotor retardation initially treated for central hypothyroidism who showed no benefit from treatment and a final diagnosis of MCT8 deficiency was made.Case report: A male infant at 13 months of age was brought to the clinic because he was unable to sit without support. The perinatal history revealed that he...

hrp0089p2-p390 | Thyroid P2 | ESPE2018

Multinodular Goiter in Childhood: Look for DICER1 Mutation

Suteau Valentine , Isabelle Souto , Natacha Bouhours-Nouet , Maryam Azgal , Justine Bailleul , Marie-Neige Campas , Aurelie Donzeau , Patrice Rodien , Regis Coutant

Introduction: Multinodular goiter (MNG) is a common disorder of the thyroid gland, characterized by thyroid enlargement due to the development of multiple hyperplastic nodules. It is infrequent in children. Here, we present the case of two families with novel DICER1 mutations and familial history of nodules in adolescence.Observations: A 10-year-old female presented a MNG. TSH, Free T3, Free T4 were in the normal range and thyroid autoantibodies were neg...

hrp0089p2-p391 | Thyroid P2 | ESPE2018

Application of Elastography in Assesment of Different Benign Thyroid Lesions in Children and Adolescents

Borysewicz-Sańczyk Hanna , Dzięcioł Janusz , Sawicka Beata , Florczykowska Patrycja , Przychodzen Małgorzata , Bossowski Artur

Introduction: Elastography is a noninvasive imaging technique based on estimation of the tissue flexibility. There are two methods of elastography: Static Elastography and Shear Wave Elastography. Scale of deformation under pressure is presented as a colourful map – elastogram, where red colour signify soft tissues, green colour signify middle tough tissues and blue colour signify tough tissues. Analysis of elastograms enable us to present results as ROI1/ROI2 index. In a...

hrp0089p2-p392 | Thyroid P2 | ESPE2018

Clinical Characteristics and Predictive Factors for the Detection of Thyroid Cancer in Children with Thyroid Nodules

Suh Junghwan , Choi Han Saem , Kwon Ah Reum , Chae Hyun Wook , Kim Duk Hee , Kim Ho-Seong

Thyroid nodules in children are less common than adults. However, pediatric thyroid nodules have higher rate of malignancy compared with adults, and also have increased risk of metastasis and recurrence. In this study, we analyzed clinical features, laboratory findings, and thyroid ultrasound (US) of children with thyroid nodules to determine predictive factors of thyroid cancer. Total 268 patients under 18 years of age with thyroid nodule whom visited Severance Children’...

hrp0089p2-p393 | Thyroid P2 | ESPE2018

Thyroid Nodules in Prader-Willi Syndrome

Grugni Graziano , Minocci Alessandro , Sartorio Alessandro , Crino Antonino

Objectives: Prader-Willi syndrome (PWS) is a complex multisystem disorder due to loss of expression of paternally derived genes in the PWS critical region on chromosome 15q11-q13. The majority of the cases are due to the deletion of this region (del15), while 20–30% are caused by a maternal uniparental disomy of chromosome 15 (UPD15). The clinical picture is characterized by neonatal hypotonia and feeding difficulties in early infancy, early development of hyperphagia wit...

hrp0089p2-p394 | Thyroid P2 | ESPE2018

Early Medullary Thyroid Carcinoma (MTC) in an Infant with Multiple Endocrine Neoplasia Type 2B (MEN2B, RETS Mutation codon 891)

Alkhalaf Fawziya , Soliman Ashraf

Introduction: An age-related progression from C-cell hyperplasia to medullary thyroid carcinoma (MTC) is associated with various germ-line mutations in the rearranged during transfection (RET) proto-oncogene that could be used to identify the optimal time for prophylactic surgery. In 207 patients from 145 families there was a significant age-related progression from C-cell hyperplasia to MTC. Thus, early diagnosis and prevention are particularly crucial....

hrp0089p2-p395 | Thyroid P2 | ESPE2018

Serum Level of Biotin Rather than the Daily Dose is the Main Determinant of the Interference on Thyroid Function Assays in Patients with Biotinidase Deficiency

Paketci Ahu , Kose Engin , Calan Ozlem Gursoy , Acar Sezer , Teke Pelin , Demirci Ferhat , Abacı Ayhan , Demir Korcan , Arslan Nur , Bober Ece

Introduction: High doses of biotin are reported to cause incorrect results in various immunoassays in some patients. However, there is no systematic study regarding biotin interference in childhood.Aim: To assess thyroid function with different methods in subjects with biotinidase deficiency, to determine the factors causing interference, and to investigate the efficiency of the methods for overcoming interference.Method: The study...

hrp0089p2-p396 | Thyroid P2 | ESPE2018

Thyroid Function Tests and Affecting Factors in Twins and Triplets

Kelesoglu Emre , Atay Zeynep , Abali Saygin , Atay Enver , Turan Murat , Gundogdu Semra , Ceran Omer

Aim: To evaluate thyroid function tests and affecting factors in twin and triplet newborns.Method: 655 newborns from 320 multiple gestations (305 twins/15 triplets) were evaluated retrospectively with respect to thyroid function tests (FT4, TSH). The effects of birth order, birth weight SDS, gestational age, maternal thyroid disease, gestational diabetes, assisted reproduction, dopamine were analysed.Results: Gestational age was 25...

hrp0089p2-p397 | Thyroid P2 | ESPE2018

Hypothyroidism in a Child During Treatment with Nivolumab for a Glioblastoma

H Birkebaek Niels , Dahl Christine

Objective: The programmed cell death 1 protein (PD1) is a T lymphocyte membrane receptor, which when bound to its ligand PD – L1 inactivates the cytotoxic T lymphocyte, thereby down regulating the immune response. Cancer may upregulate PD – L1 on the cell surface, further downregulating the immune response. Nivolumab, a so called check point inhibitor, is a PD1 antibody, and when bound to PD1 keep the cytotoxic T lymphocyte active. Cytotoxic T lymphocyte activation b...

hrp0089p2-p398 | Thyroid P2 | ESPE2018

Diagnosis and Clinical Course of Amiodarone Induced Hyperthyroidism in Three Adolescent Patients

Gesing Julia , Hoppmann Julia , Gebauer Roman , Pfaffle Roland , Bertsche Astrid , Kiess Wieland

Amiodarone induced hyperthyroidism is a known side effect of amiodarone treatment. In the pediatric population long-term amiodarone treatment is rarely indicated because of its severe side effects including thyroid function impairment and therefore treatment is restricted to therapy resistant arrhythmias. In the literature scarce data is available on management and therapy of amiodarone induced thyroid dysfunction at a young age. We present three adolescent patients developin...

hrp0089p2-p399 | Thyroid P2 | ESPE2018

Allogenic Bone Marrow Transplantation in Children: Effect on Thyroid Function

Vlachopapadopoulou Elpis Athina , Paisiou Anna , Stergiotis Stefanos , Ioannidou Eleni Dikaia , Goussetis Eugenios , Kafetzi Maria , Kitra Vassiliki , Michalacos Stefanos

Objective: To report the incidence of thyroid dysfunction of patients who underwent allogenic BMT during childhood.Patients and Methods: Eighty-two patients (56 boys) who were transplanted from an HLA matched donor at a mean age of 7.5±4.8 years (range 0.18–17.5 years) were followed prospectively having measurements of fT4, TSH twice yearly, using chemiluminescence. Patients with elevated TSH higher than 8 μIU/ml had a repeat evaluation in...

hrp0089p2-p400 | Thyroid P2 | ESPE2018

Follow-up in Children with Non-obese and Non-autoimmune Subclinical Hypothyroidism

Ergin Zeynep , Savas-Erdeve Senay , Kurnaz Erdal , Cetinkaya Semra , Aycan Zehra

Introduction: Subclinical hypothyroidism is a form of thyroid dysfunction in which TSH level is high while serum free thyroxin (fT4) and free triiodothyronine (fT3) are within normal reference range. In this study, it was aimed to investigate effects of subclinical hypothyroidism on anthropometric characteristics, blood pressure, glucose and lipid metabolism by evaluating course of subclinical hypothyroidism during follow-up without treatment.<p class...

hrp0089p2-p401 | Thyroid P2 | ESPE2018

Clinical Management of Childhood Hyperthyroidism: A Longitudinal Study at a Single Center

Dos Santos Tiago Jeronimo , Martos-Moreno Gabriel , Munoz-Calvo Maria , Pozo Jesus , Rodriguez-Artalejo Fernando , Argente Jesus

Background: The approach to clinical management of Graves’ disease (GD) is debatable.Objective: This study aimed to identify predictors of remission in pediatric GD.Methods: A longitudinal study of 36 children and adolescents with Graves’ disease followed from 1997 to 2017 at a single pediatric tertiary hospital was performed. Clinical and biochemical parameters, including comorbidities, treatment with anti-thyroid drugs ...

hrp0089p2-p402 | Thyroid P2 | ESPE2018

Association of Thyroid Stimulating Hormone and Free Thyroxine with Cardiometabolic Risk Factors in Euthyroid Korean children and Adolescents Aged 10–18 Years: The Korean National Health and Nutrition Examination Survey 2015

Lim Jung Sub , Shim Young Suk , Kim Eun Young

Objective: The present study aimed to evaluate the association of free thyroxine (FT4) and TSH with insulin resistance indices in euthyroid Korean children and adolescents using nationally representative data.Methods: A total of 259 children and adolescents were included in data from The Korean National Health and Nutrition Examination Survey 2015.Results: TSH levels were significantly positively associated with HOMA-IR (β...

hrp0089p2-p403 | Thyroid P2 | ESPE2018

Asymptomatic Hyperthyrotropinaemia in Children, Does it Correlate to true Thyroid Gland Dysfunction?

Kappou Kalliopi , Bisbinas Vasiliki , Karabouta Zacharoula

Introduction: Thyroid stimulating hormone (TSH) abnormalities are a frequent laboratory test finding, which may hinder thyroid dysfunction. One of the most accurate laboratory methods for testing thyroid function (TFTs) is the radioimmunoassay (RIA) method. RIA is an immunoassay that uses radiolabelled molecules in a stepwise formation of immune complexes. It is a very sensitive in vitro assay technique used to measure concentration...

hrp0089p2-p404 | Thyroid P2 | ESPE2018

Hearing Loss Among Patients with Congenital Hypothyroidism

Almagor Tal , Nachtigal Dan , Sharoni Zohara , Elias-Assad Ghadir , Hess Ora , Havazelet Gilad , Tenenbaum-Rakover Yardena

Background: A high rate of hearing impairment has been reported in patients with congenital hypothyroidism (CH). However, this association has only been explored in a few studies with inconclusive findings.Objectives: To assess the prevalence of hearing impairment among patients with CH and determine whether hearing impairment is related to delay in supplemental therapy, etiology of CH or other parameters.Methods: Audiometry was un...

hrp0089p2-p405 | Thyroid P2 | ESPE2018

Predictors of Permanent Congenital Hypothyroidism in Children

Yoon Ju Young

Background: Congenital hypothyroidism (CH) is one of most common endocrine disease in childhood. If unteated, it is one of the leading causes of childhood intellectual disability. CH can be permanent, or can be transient in which thyroid function is spontaneously recovered. It is also known that among children with congenital hypothyroidism, the proportion of transient cases is higher in preterm than in full term babies. But there are few, if any, large studies which evaluated...

hrp0089p2-p406 | Thyroid P2 | ESPE2018

Absence of Uptake on Scintigraphy Does Not Always Correlate with Athyreosis: Re-evaluation of Patients Diagnosed with Athyreosis Over a 10 Year Period in the Republic of Ireland

McGrath N , Hawkes CP , Ryan S , Mayne P , Murphy NP

Background: Thyroid imaging is recommended to determine the aetiology of congenital hypothyroidism (CHT). Currently scintigraphy is the gold standard imaging modality. Negative scinitigraphy despite the presence of thyroid tissue may lead to a spurious diagnosis of athyreosis. Few centres routinely perform both scinitgraphy and ultrasound so that the incidence of misclassified athyreosis is unknown.Aim: To describe the incidence of sonographically normal...

hrp0089p2-p407 | Thyroid P2 | ESPE2018

Bannayan-Riley-Ruvalcaba Syndrome with PTEN Mutation in a Patient Affected by Congenital Hypothyroidism due to TPO Gene Alteration

Vincenzi Gaia , Vigone Maria Cristina , Peroni Elena , Saracco Luca , Paesano Pier Luigi , Maggiore Riccardo , Mari Gilberto , Patricelli Maria Grazia , Weber Giovanna

We present the case of a 7-year-old female affected by permanent congenital hypothyroidism and Bannayan-Riley-Ruvalcaba syndrome. The patient was born at 31+4 gestational weeks because of premature rupture of membranes. At birth her auxological parameters were adequate for gestational age with a 75th percentile head circumference. She was diagnosed with congenital hypothyroidsm (TSH 1016 mcu/ml, FT4 <0.4 ng/dl) with an in situ gland caused by a homozygous mutation...

hrp0089p2-p408 | Thyroid P2 | ESPE2018

The Congenital Hypothyroidism Screening Programme in a Sigle Italian Centre: a 5-Years Retrospective Study

Maggio Maria Cristina , Ragusa Saveria Sabrina , Aronica Tommaso Silvano , Granata Orazia Maria , Gucciardino Eleonora , Corsello Giovanni

Congenital hypothyroidism (CH) occurs in approximately 1:2000–1:3000 newborns in Italy. Lowering of the TSH cut-off was the most important factor contributing to the increase of CH incidence in Italy. The aim of this study is the determination of the prevalence of CH in northwest Sicily, evaluated by the single screening centre of the Children Hospital ‘G. Di Cristina’, ARNAS, Palermo. From January 2013 to December 2017, 79.699 newborns were screened testing TSH...

hrp0089p2-p409 | Thyroid P2 | ESPE2018

Do Insulin Like Growth Factors also Influence Growth in Children with Congenital Hypothyroidism: A Cohort Analysis

Yadav Sangita , Goel Ruchi , Mantan Mukta , Mishra T K

Introduction: Congenital Hypothyroidism if not treated timely presents with growth & developmental delay. Thyroid hormones and Growth hormone- Insulin like growth factor 1 axis (GH-IGF-1) together are critical for somatic and skeletal growth. Hypothyroidism and derangement in this axis leads to profound growth retardation and delayed skeletal maturation. Limited studies suggest that thyroxine directly regulates IGF-1 independent of GH in congenital hypothyroidism.<p cl...

hrp0089p2-p410 | Thyroid P2 | ESPE2018

Study of Hearing Function in Children with Congenital Hypothyroidism Attending Alexandria University Children’s Hospital

Elsayed Shaymaa , Wafa Ehsan , Elmoazen Doaa , Elsayed Haidy

Introduction: Congenital hypothyroidism (CH) is the most common congenital endocrine disorder in childhood and is one of the most common preventable causes of mental retardation. Thyroid hormones (TH) are essential for normal development of auditory system. Deficiency of TH during fetal and early postnatal sensitive periods of ear development, results in various degree of congenital hearing impairments or even in deafness if TH substitution is not instituted within a critical ...

hrp0089p2-p411 | Thyroid P2 | ESPE2018

Awareness of the Risks of Acquired Iodine Deficiency in Strict Vegan Diets

Brandt Agnieszka , Cheung Moira , Sakka Sophia , Ajzensztejn Michal , Hulse Tony

Background: Iodine deficiency is the most common cause of acquired hypothyroidism worldwide but rare in developed countries. Incidence of iodine deficiency may be rising due to increased popularity of vegan diets. There is minimal information on official health promotional webpages alerting to this risk.Case presentation: We present a 2.5yr old boy and his 6yr old sister from a family who adhere to a strict vegan diet and additional dietary restriction i...

hrp0089p2-p412 | Thyroid P2 | ESPE2018

Thyroid Function in the Korean Obese Children and Adolescents: Korea National Health and Nutrition Examination Survey 2013 to 2015

An Youngmin , Eun Lee Ji , Ju Suh Young

Purpose: In recent years, there has been an increasing focus on thyroid function in pediatric obese patients, but no nationwide study evaluating the relationship between thyroid function and obesity has yet been conducted in Korea. We aimed to evaluate thyroid dysfunction in obese Korean children.Methods: We analyzed the association between obesity and thyroid hormone levels among 975 Korean boys and girls aged 10–18 years, who participated in the K...