ESPE Abstracts

ESPE Abstracts

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57th Annual ESPE (ESPE 2018)

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

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Fat, Metabolism and Obesity

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Fetal, Neonatal Endocrinology and Metabolism

hrp0089rfc6.7 | Fat, Metabolism and Obesity | ESPE2018

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hrp0089rfc6.2 | Fat, Metabolism and Obesity | ESPE2018

IGF-I at Four Months Associates to Visceral and Subcutaneous Adipose Tissue at 7 Years of Age

Kjellberg Emma , Roswall Josefine , Andersson Jonathan , Bergman Stefan , Kullberg Joel , Dahlgren Jovanna

Objectives and Study: Insulin-like growth factor I (IGF-I) regulates fetal and infant growth and is influenced by nutrition during infancy. Breast fed children have lower IGF-I levels than formula fed infants and the reason is partly explained by lower levels of protein and higher level of polyunsaturated fatty acids (PUFA) in breast milk compared to formula. Environmental factors, such as nutrition, have long-lasting influences on hormone secretion and on future metabolic hea...
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hrp0089rfc6.3 | Fat, Metabolism and Obesity | ESPE2018

Effect of the Melanocortin-4 Receptor Agonist, Setmelanotide, on Obesity and Hyperphagia in Individuals Affected by Bardet-Biedl Syndrome

Haws Robert M , Fletty Kristina L , McIntee Thomas J , Green Clayton , Pomeroy Jeremy , Hylan Michelle , Folster Cathy , Davis Elisabeth K , Brady Sheila M , Fiedorek Fred T , Yanovski Jack A

Background: Bardet-Biedl syndrome (BBS) causes early-onset extreme obesity and hyperphagia that is hypothesized to arise from leptin receptor dysfunction. Setmelanotide, a melanocortin-4 receptor (MC4R) peptide agonist, has been shown to induce weight loss in individuals affected by other rare genetic obesity disorders resulting from leptin-melanocortin pathway dysfunction upstream of MC4R.Objective: Report preliminary data on body weight, hunger scores,...
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hrp0089rfc6.4 | Fat, Metabolism and Obesity | ESPE2018

Functionality and Phenotypic Characteristics of Mutations in the Human Leptin Receptor

Nunziata Adriana , Funcke Jan-Bernd , Borck Guntram , von Schnurbein Julia , Lennerz Belinda , Moepps Barbara , Gierschik Peter , Fischer-Posovszky Pamela , Wabitsch Martin

Objective: Merge and standardize the scarce data on molecular and phenotypic findings of mutations in the human leptin receptor (LEPR) gene causing a rare form of severe early-onset obesity.Methods: We summarized functional and phenotypic traits of LEPR mutations reported in the literature in a structured and comprehensive manner. Additional data was obtained from 6 subjects of our outpatient clinic not reported so far. Functionality of mutations was ass...
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hrp0089rfc6.5 | Fat, Metabolism and Obesity | ESPE2018

High-Throughput Untargeted Plasma Metabolomics Unravels Gender Dimorphic Metabolic Trajectories in Naturally Conceived and ICSI Prepubertal Children

Telonis Aristeidis G , Gkourogianni Alexandra , Papassotiriou Ioannis , Konsta Maria , Papastamataki Maria , Margeli Alexandra , Bartzeliotou Anastasia , Mantzou Emilia , Kosteria Ioanna , Mastorakos George , Loutradis Dimitrios , Chrousos George P , Klapa Maria I , Kanaka-Gantenbein Christina

Background: Accumulating evidence has indicated that assisted reproductive technologies (ART) influence the metabolic physiology of the offspring, with a higher predisposition to metabolic disorders. Long-term metabolomic studies that separately consider males and females conceived with intra-cytoplasmic sperm injection (ICSI) vs naturally conceived (NC) children are needed. Previously, we had reported that ICSI-conceived prepubertal girls exhibit significant alterations in th...
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hrp0089rfc6.6 | Fat, Metabolism and Obesity | ESPE2018

Effects of Cherry’s Extract on Increased Osteclastogenesis in Obese Children

Faienza Maria Felicia , Corbo Filomena , Carocci Alessia , Catalano Alessia , Piacente Laura , Clodoveo Maria Lisa , Bortolotti Sara , Storlino Giuseppina , Colucci Silvia , Grano Maria , D'Amato Gabriele , Brunetti Giacomina

The accumulation of adipose tissue, especially visceral fat, represents a risk factor for reduced bone mineral density and spontaneous fractures. Several mechanisms have been proposed to explain the complex relationship between adipose tissue and bone. Obesity is associated with the production of inflammatory cytokines both by adipocytes and immune cells which may stimulate bone resorption and reduce bone strength. Studies in vitro and in vivo have reported t...
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