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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

Rapid Free Communications

Fetal, Neonatal Endocrinology and Metabolism

hrp0089rfc7.1 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2018

Next Generation Sequencing Results in 142 Patients with Congenital Hyperinsulinism

Gubaeva Diliara , Melikyan Maria , Vasiliev Eugeny , Petrov Vasily , Tiulpakov Anatoly

Congenital hyperinsulinism (CHI) is a life-threatening disorder characterized by hypoglycemia due to dysregulated secretion of insulin from pancreatic β-cells. Genetic diagnosis is essential for patient management. NGS technologies give the ability to generate large amounts of sequence data in a relatively short amount of time. We report next generation sequencing (NGS) results in 142 patients (66 boys, 76 girls) with CHI seen at Endocrine Research Centre (Moscow...

hrp0089rfc7.2 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2018

Outcomes of a Quality Improvement Project Integrating Continuous Glucose Monitoring Systems into the Routine Management of Neonatal Hypoglycaemia

McGlacken-Byrne Sinead , Jenkinson Allan , O'Neill Roisin , Murphy John

Introduction: Empirical research studies suggest that continuous glucose monitoring systems (CGMS) are safe and could optimize neonatal hypoglycaemia management. However, they need to be tested within resource-limited, time-constrained clinical practice. CGMS was piloted in our Level 3 Neonatal Intensive Care Unit (NICU) in June 2017. Five key barriers to its effective implementation were identified: i) Lack of NICU staff confidence in device usage ii) Infant discomfort during...

hrp0089rfc7.3 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2018

Central Venous Cathether-Associated Thrombosis in Children with Congenital Hyperinsulinism

Yau Daphne , Salomon-Estebanez Maria , Chinoy Amish , Murray Philip G , Banerjee Indi

Introduction: Congenital hyperinsulinism (CHI) is the most common cause of hypoglycaemia in infancy caused by dysregulated insulin secretion. The management of severe hypoglycaemia often requires the administration of high dextrose-containing fluids through a central venous catheter (CVC). However, CVCs carry the risk of complications including thrombosis. We sought to determine the incidence of CVC-associated thrombosis in patients with CHI and examine associated risk factors...

hrp0089rfc7.4 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2018

Expression of MIR-576-5p in Umbilical Cord as a Novel Biomarker for the Identification of Catch-up Growth in Small-For-Gestational-Age Infants

Bassols Judit , Mas-Pares Berta , Bonmati Alexandra , Xargay-Torrent Silvia , Carreras-Badosa Gemma , Lizarraga-Mollinedo Esther , Martinez-Calcerrada Jose-Maria , de Zegher Francis , Ibanez Lourdes , Lopez-Bermejo Abel

Background: Early catch-up growth, between birth and age two years, in infants born small-for-gestational-age (SGA) is a risk factor for the development of cardiometabolic diseases in adulthood. The basis and mechanisms underpinning catch-up growth in SGA newborns are unknown.Objectives: We aimed to investigate the catch-up predictive ability of cord blood miRNAs in SGA infants.Methods: MicroRNA PCR Human Panels were used to study ...

hrp0089rfc7.5 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2018

Alteration of Renal Corticosteroid Signaling Pathways in Preterm Infants: Neonatal Adaptation and Developmental Programming of Hypertension

Dumeige Laurence , Nehlich Melanie , Lhadj Christophe , Viengchareun Say , Xue Qiong-Yao , Pussard Eric , Lombes Marc , Martinerie Laetitia

Introduction: Prematurity, a worldwide health issue, is often associated with renal tubular immaturity leading to major salt loss, whose mechanisms remain poorly understood. Moreover, these premature infants are prone to develop hypertension early in adulthood.Objective: To study the ontogenesis of renal mineralocorticoid and glucocorticoid signaling pathways in preterm infants and to evaluate their respective role during neonatal adaptation and in the e...

hrp0089rfc7.6 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2018

Assessment of Pituitary Stalk Anatomy by T2 DRIVE without Gadolinium in Pituitary Diseases

Napoli Flavia , Godano Elisabetta , Morana Giovanni , Di Iorgi Natascia , Pistorio Angela , Allegri Anna Elsa Maria , Gastaldi Roberto , Calcagno Annalisa , Patti Giuseppa , Gallizia Annalisa , Notarnicola Sara , Giaccardi Marta , Noli Serena , Severino Mariasavina , Tortora Domenico , Rossi Andrea , Maghnie Mohamad

Objectives: To evaluate the potential diagnostic role and sensitivity of T2-weighted DRIVE sequence in pituitary stalk (PS) identification and measurements in patients with hypothalamic-pituitary disorders. The degree of agreement and reliability between standard pre- and post-contrast T1-weighted images and T2-DRIVE will be tested in a large group of patients with pituitary dysfunction.Design: We searched for pituitary MRI reports using ‘T2-DRIVE&#...