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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece


Special Symposia: Nutrition and Growth

hrp0089ss1.1 | Special Symposia: Nutrition and Growth | ESPE2018

It is not Just the Growth Hormone-IGF-I Axis

Nilsson Ola

For decades, the dominant conceptual framework for understanding short and tall stature was centered on the GH-IGF-I axis. However, recent findings in basic molecular and cellular biology and in clinical genetics have uncovered a vast array of other regulatory systems that control skeletal growth and an accompanying vast array of genetic defects outside the GH-IGF-I axis that can cause disorders of linear growth. As a result, the traditional view of short or tall stature that ...

hrp0089ss1.2 | Special Symposia: Nutrition and Growth | ESPE2018

Fascinating Growth Phenomena: What Causes Individual Catch-up Growth and Population Secular Change?

Wit Jan M

Catch-up growth (CUG) is characterized by a period of supranormal height velocity following a transient period of growth inhibition. The two classical hypotheses on the mechanism are the neuro-endocrine hypothesis (a central mechanism that would recognize the degree of mismatch between actual size and target size) and the growth plate hypothesis (local regulation of growth according to a preset cellular program of senescence, characterized by decreasing growth proliferation ra...

hrp0089ss1.3 | Special Symposia: Nutrition and Growth | ESPE2018

Interaction between Nutrition, the Endocrine System and the Growth Plate

Phillip Moshe

ChildrenÂ’s linear growth is a complex process determined by genetic and environmental factors. It is well known that nutrition influences linear growth, but the precise mechanisms by which nutrition interact with height gain was never fully elucidated. In the present lecture, the way by which nutrition affects linear growth will be discussed. Specifically, we will discuss the effect of nutrition on the GH- IGF-1 axis and its local effect on the chondrocytes of the epiphys...