ESPE Abstracts

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Multiple studies have examined the relationship between BMI and timing of the onset of puberty. The more salient measure of this relationship may be adiposity, which can be represented by fat mass, BMI z-score, or waist-to-height ratio. The relationship of greater BMI or adiposity to earlier pubertal onset in girls is generally consistent, and several mechanisms have been proposed. These potential mechanisms include impact of adiposity on leptin concentrations, altere...

Central precocious puberty (CPP) may have endocrine and metabolic implications in adulthood. Long-term effects may be associated with the underlying neuroendocrine dysfunction leading to CPP, the GnRH analogue (GnRHa) therapy, or both. Data are conflicting on the long-term risk of polycystic ovarian syndrome in both treated and untreated women. Clinical hyperandrogenism has been more frequently reported in CPP women than in controls, with no significant difference between GnRH...

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