ESPE Abstracts (2018) 89 P-P2-297

Polycystic Ovary Syndrome Metabolic Syndrome Predisposition in Puberty

Styliani Geronikoloua,b, Flora Bacopouloua, Stavros Chryssanthopoulosb & Dennis Cokkinosb

aFirst Department of Paedaitrics, National and Kapodistrian University of Athens Med School, Aghia Sophia Hospital, Athens, Greece; bBiomedical Research Foundation of The Academy of Athens, Athens, Greece

This case control study aims at investigating the cardiovascular profile of Greek adolescents suffering from polycystic ovary syndrome (PCOS) by comparing them with age- and body mass index (BMI)- matched non-PCOS controls. Nineteen PCOS patients and eighteen non-PCOS controls (aged 13 to 23 years) were studied for: (i) bioreflex sensitivity (BRS), as a marker of cardiac function, (ii) carotid pulse pressure (PP) and subendocardial viability ratio (SEVR), as markers of arterial stiffness, and, (iii) intima medial thickness (IMT), as a marker of arterial thickness. Non- parametric statistical analysis showed significant differences between PCOS patients and controls in arterial stiffness measured by pulse pressure PP (P=0.006) and SEVR (P=0.0042). No differences were detected in BRS or IMT. As expected, a strong correlation of PP and IMT showed relations between cyclic stress and arterial remodeling (Spearman’s Rho coefficient is - 0.603 P=0.023) in carotid (elastic) artery. The arterial stiffness results illustrate early onset of vascular dysfunction, predisposition to hypertension and metabolic syndrome in adolescents with PCOS.

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