This case control study aims at investigating the cardiovascular profile of Greek adolescents suffering from polycystic ovary syndrome (PCOS) by comparing them with age- and body mass index (BMI)- matched non-PCOS controls. Nineteen PCOS patients and eighteen non-PCOS controls (aged 13 to 23 years) were studied for: (i) bioreflex sensitivity (BRS), as a marker of cardiac function, (ii) carotid pulse pressure (PP) and subendocardial viability ratio (SEVR), as markers of arterial stiffness, and, (iii) intima medial thickness (IMT), as a marker of arterial thickness. Non- parametric statistical analysis showed significant differences between PCOS patients and controls in arterial stiffness measured by pulse pressure PP (P=0.006) and SEVR (P=0.0042). No differences were detected in BRS or IMT. As expected, a strong correlation of PP and IMT showed relations between cyclic stress and arterial remodeling (Spearmans Rho coefficient is - 0.603 P=0.023) in carotid (elastic) artery. The arterial stiffness results illustrate early onset of vascular dysfunction, predisposition to hypertension and metabolic syndrome in adolescents with PCOS.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology