Background: In this study, we aimed to investigate the relationship between single-gender Korean references for non-high-density-lipoprotein cholesterol (non-HDL-C) and metabolic syndrome (MetS) in childhood.
Methods: A total of 5,742 Korean children aged 1018 years who participated in a national survey were included. The subjects were classified into three groups based on single-gender non-HDL-C levels as follows: <120 mg/dl (desirable), ≥120 and <150 mg/dl (borderline high), and ≥150 mg/dl (high).
Results: Males in the borderline high non-HDL-C group had odds ratios (ORs) of 2.86 (95% CI, 2.303.56) for elevated triglycerides (TG), 1.73 (1.081.79) for reduced high-density lipoprotein cholesterol (HDL-C) and 1.73 (1.082.78) for MetS compared with males in the desirable non-HDL-C group after adjusting for covariates. Males in the high non-HDL-C group had ORs of 1.65 (1.142.41) for elevated blood pressure (BP), 6.21 (4.279.05) for elevated TG, and 3.29 (1.497.26) for MetS compared with males in the desirable non-HDL-C group. Females in the borderline high non-HDL-C group had ORs of 3.03 (2.433.76) for elevated TG, 1.63 (1.132.35) for reduced HDL-C, and 4.53 (2.478.31) for MetS compared with females in the desirable non-HDL-C group. Females in the high non-HDL-C group had ORs of 1.43 (1.002.04) for elevated BP, 6.36 (4.459.08) for elevated TG, and 7.64 (3.6515.96) for MetS compared with females in the desirable non-HDL-C group.
Conclusions: Our results suggest that in a Korean population, a non-HDL-C level of 120 mg/dl for males and 150 mg/dl for females is the threshold between borderline high and high risk for MetS.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology