ESPE Abstracts (2018) 89 P-P1-132

ESPE2018 Poster Presentations Fat, Metabolism and Obesity P1 (42 abstracts)

Non-Invasive Measurements of Central Blood Pressure with Arterial Stiffness Indicators as a New Research Tool for Predicting Cardiovascular Risk in Children with Type 1 Diabetes Mellitus and Obesity

Klaudyna Noiszewska , Mateusz Puchalski , Anna Skolimowska & Artur Bossowski

Department of Pediatrics, Endocrinology, and Diabetology with Cardiology Division, Medical University of Białystok, Białystok, Poland

Introduction: The main problem of contemporary diabetology is to prevent chronic complications of carbohydrate metabolism disorders according to DM1 and obesity (pre-disposing for DM2). The task is to find simple tools that allow rapid identification of vascular lesions and early treatment intervention.

Aim of the study: The aim of the study was to evaluate parameters of CBP in patients with DM1 and obesity

Materials and methods: The study conducted 100 children matched for age (mean 13 years), body weight, height and sex. The control group consisted of 35 healthy children (W: 21, M: 14). The study groups: DM1 for <5 years (W: 9(A), M: 12(B)), DM1 > 5 years (W: 12(C), M: 13(D)) and patients with obesity (W: 9(E), M: 10(F)) under the care of the Department of Paediatrics, Endocrinology and Diabetology at UDSK in Bialystok. In Addition, on the basis of the HbA1c level the DM1 patients were divided into 2 groups (HbA1c below(G) or above 7.5% (H)). Three CBP measurements were made using Centron Diagnostic System, and the mean values were calculated. Statistical analysis was performed using Stat 12.5 (student’s t test).

Results: A clear trend was observed, both in girls and boys with DM1, for unfavourable variability of vascular stiffness indexes (AUG/AMP for WW; A;C resp. 0.58/1.75; 0.62/1, 64, 0.59/1.74; MM; MM: B;D >5 years resp. 0.58/1.78; 0.62/1.65, 0.59/1.75) without statistical relevance between groups. Patients C and D were characterized by a better AUG and AMP than the groups A and B regardless of gender. Both groups independently of HbA1c showed no statistically significant differences in vessel elasticity. However, in both obese E and F group we observed statistically significantly higher values of CBP and PP (CBP/PP for E vs Ko resp. 99/28 vs 124/36, P=0.007/0.007; F vs Mo resp. 100/33 vs 114/36 P=0.004, 0.3)

Conclusions: Indices AUG and AMP showed a more favourable variability in children suffering longer in the majority of those remaining on insulin pumps with better metabolic control. The values of the studied parameters were worse in the group with DM1 <5 years, possibly as a residue of ketoacidosis at the time of diagnosis or treatment with pens. Obesity admittedly predisposes to increase the CBP.

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