Background/aims: AMH levels of mini puberty are higher than prepubertal period. In this study we investigated AMH levels in infants with premature thelarche who are presumed to have exaggerated mini puberty due to inadequate/late suppression of pubertal activation.
Methods: Fifty five female infants between 3 months and 3 years of age with premature thelarche were enrolled in the study and 49 healthy girls in the same age group were included in the study. Bone age, pelvic ultrasonography (USG) findings and AMH level of the patient group and serum AMH level of the control group were evaluated.
Results: Serum AMH levels of premature thelarche (med: 1.66 min-max: 0.157.28 ng/ml) were significantly lower than the control groups (med: 2.46 minmax: 0.608.49 ng/ml) (P: 0.015). AMH and FSH were negatively correlated (r: −0.412 P: 0.002) in infants with premature thelarche.
Conclusion: This is the first study to investigate AMH levels in infants with premature thelarche. It was concluded that AMH may play a role of suppressing pubertal findings during the mini-puberty period and decreased of AMH may cause premature thelarche in infants as a result of exaggerated mini-puberty because of detection of AMH levels in infants with premature thelarche less than healthy controls and a negative correlation between AMH and FSH.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology