ESPE Abstracts (2018) 89 P-P3-044

Erciyes University Department of Pediatric Endocrinology, Kayseri, Turkey

Objective: According to the etiology of hyperparathyroidism, it is divided into primer and secondary (uremic). It usually develops due to CaSR mutation in the infancy period. On the other hand, it usually emerges secondary to a parathyroid adenoma in adolescents. Parathyroid adenomas seen in childhood are commonly associated with familial multiple neoplasia syndromes (MEN). Patients may present with bone pain, proximal myopathy, fractures, renal stone, pancreatitis or they can also be completely asymptomatic. Herein, clinical features of 8 patients with primary and secondary parathyroid adenomas diagnosed in our clinic in the last 2 years are presented and treatment approaches are shared.

Case: Eight children who have been treated with hyperparathyroidism for the last 2 years and who are taking follow-up care have been evaluated. The reasons for referral, hormonal and biochemical evaluation of the patients, and the treatments applied were evaluated. The M/F ratio of the patients is 3/5, and the age ranges are 8–15 years. Attending symptom was abdominal pain in one patient. Three of the cases had secondary hyperparathyroidism due to treatment of hypophosphatemic rickets. The other five were sporadic. None of them had family history or MEN-related clinical findings. All patients had localized adenomas and all but two of them underwent surgery The pathological evaluations were compatible with the adenoma.

Result: Parathyroid gland disease is a rare condition in children, usually present with primary hyperparathyroidism due to a parathyroid adenoma as in our cases. The disease was more common in girls. Most of the patients were asymptomatic. There were no MEN-related findings or family history in presented cases. We tried to take attention to the issue by sharing the experience of our clinic in this rare disease

Keywords: parathyroid adenoma, hyperparathyroidism, hypercalcemia

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