Acnathosis nigricans (AN) is known to be common dermatologic manifestation in obese children and adolescents. The aim of this study is to examine the association of AN and insulin resistance in obese children and adolescents. One hundred seventy-nine obese subjects aged 6-17 years who participated in the intervention study, Childhood and Adolescents Obesity via Activity and Nutrition (ICAAN) study, were enrolled in 2017-2017. AN was diagnosed by physician. Anthropometric measurements and blood sampling including fasting glucose, insulin, aspartate transaminase (AST), alanine transaminase (ALT), and leptin levels were assessed. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from FPG and insulin using the equation. One hundred ten of subjects were male (61.5%). Eighty-four subjects (48.3%) had AN. The rate of severe obesity was significantly higher in AN group than non-AN group (24.2% vs. 48.8%, P=0.001). Mean BMI, ALT, rGT, HOMA-IR, and leptin levels were significantly higher in AN group. The rate of severe obesity and HOMA-IR increased with the severity of AN. Early identification of AN in obese children and adolescent can be recommended for screening of insulin resistance.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology