Introduction: The impact of gestational diabetes mellitus (GDM) on fetal development and the future health of the child need further studying. In accordance to the criteria by Hyperglycemia and Adverse Pregnancy Outcome Study, GDM can lead to a number of negative consequences, including the impact on disturbance of metabolic parameters.
Aim: To compare the impact of glycemia during pregnancy on the childrens metabolic status.
Methods: GDM was confirmed by determining the level of glycemia during the oral glucose tolerance test in pregnant women. Women were treated with insulin or diet therapy. Depending on the achievement of the target glycemia, the women were divided in 2 groups. All women were not achieve the targer levels of fasting glucose (FG) less than 5.1 mmol/L or 1 hour postprandial less than 7.0 mmol/L. Target glycemia was considered FG less than 5.3 mmol/L and/or 7.8 mmol/L after 1 hour postprandial more than 70% of the measurements. Non-target FG more than 5.3 mmol/l and/or 7.8 mmol/l after 1 hour postprandial more than 30% of the measurements. The study included 43 children at the age of 6 months, born to mothers with GDM. Group 1 (n=28) included children, from pregnancies with target glycemia, Group 2 (n=15) non-target. The level of FG, insulin, cholesterol and triglycerides of childrens plasma was studied. The statistical treatment was carried out by evaluating the significance of differences in mean values using Students t-test.
Results: No differences were find out when comparing the FG level between groups (group 1 4.63±0.56 mmol/L, group 2 4.78±0.55 mmol/L, P=0.42). The level of insulin (group 1 16.05±14.07 mmol/L, group 2 1.07±11.3 mmol/L, P=0.79) also did not differ. A similar situation was observed in the evaluation of cholesterol (group 1 3.93±0.66 mmol/L, group 2 3.53±0.73 mmol/L, P=0.41) and tryglecerides (group 1 1.1±0.75 mmol/L, group 2 0.95±0.54 mmol/L, P=0.31).
Conclusions: There was no evidence of the influence of mothers glycemia during pregnancy on changes in the level of FG, insulin, triglycerides, cholesterol in children of 6 months. Perhaps in the study of children from mothers with strict target glycemia criteria during pregnancy, other results will be obtained.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology