ESPE Abstracts (2018) 89 P-P3-257

Growth Response in Noonan Syndrome in Indian Children

Smita Ramachandran, Aashish Sethi & Inderpal Kochar

Indraprastha Apollo Hospital, Delhi, India

Objective: To evaluate the growth response in children with Noonan syndrome (NS) treated with growth hormone (rGH).

Methods: We retrospectively collected data from 2007 of pre-pubertal children with NS, their baseline auxological parameters were recorded pre and post treatment.

Results: A total 1134 were treated with growth hormone for short stature of which there were six cases of NS, constituting 0.5% of the short stature. There were three males and one females, mean age of presentation was 10.8yrs +1.78. The mean height at the start of treatment was 128.75 cm and improved to 138.13 cm after 12 months of rGH. The average height velocity was 9.38 cm/year.

Conclusion: The prevalence of NS is very limited in Indian population but timely diagnosis and treatment can result in improved final height.

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