ESPE2018 Rapid Free Communications Late Breaking (6 abstracts)
Effect of the Current Treatment of X-Linked Hypophosphatemia During Growth on the Development of Osteoarticular Lesions in the Hyp Mouse Model
Axelle Cauliez a , Carole-Anne Faraji-Bellée a , Benjamin Salmon a, , Olivier Fogel c , Aurélie Benoit d , Thorsten Schinke e , Corinne Miceli c , Karine Briot c, , Agnès Linglart f, , Catherine Chaussain a, & Claire Bardet a
aLaboratory Orofacial Pathologies, Imaging and Biotherapies EA 2496, School of Dentistry Paris Descartes University Sorbonne Paris Cité, Paris, France; bAP-HP Department of Odontology, Bretonneau Hospital, Paris, France; cAP-HP Service Rhumatologie B Hôpital Cochin, Paris, and Medical School Paris Descartes University, Paris, France; dEA 4462, URB2I, School of Dentistry, Paris Descartes University Sorbonne Paris Cité, Paris, France; eDepartment of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, Hamburg, Germany; fReference Center for Rare Diseases of Calcium and Phosphorus Metabolism, Paris, France; gAP-HP Department of Pediatric Endocrinology, Kremlin Bicêtre Hospital, School of Medicine University Paris Sud, Paris, France
Mineralization defects and paradoxical mineralizing enthesopathies are hallmarks of X-linked Hypophosphatemia (XLH), a rare skeletal disease caused by inactivating mutations in the PHEX gene (Phosphate-regulating endopeptidase homolog, X-linked). The current medical treatment, which consist in oral phosphorus supplementation and active vitamin D analogues, aimed at counteracting consequences of FGF23 excess and is commonly prescribed from early childhood to the end of growth. Despite childhood treatment of the disease, cartilaginous tissue complications in adults become a dominant feature in the clinical evolution of XLH. Here, we monitored the development of these osteoarticular lesions, characterizing the formation of enthesopathies, calcifications and osteoarthritis through a 12-months (M) Micro-CT longitudinal follow up in the Hyp mouse, a murine model of XLH. These lesions were already present at 3 months and significantly increased from 3 to 12 months, highlighting the relevance of this murine model for pre-clinical studies. We then studied the impact of current treatment on the development of these osteoarticular lesions. Hyp mice were treated with oral phosphorus supplementation and calcitriol injections. The treatment followed two different outlines: i) from 3 weeks to 3 months to analyze the treatment effects during growth and ii) from 2 months to 3 months to analyze the treatment effects on adult lesion development. We showed that the current treatment given since the early stage improved osteoarticular lesions, bone mineralization and micro architecture, and fusion of the growth plate. Future studies should compare the effect of the new therapy based on anti-FGF23 antibody.
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