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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Plenary Lectures

RANKL and RANK: Bone and Beyond

hrp0092pl1 | RANKL and RANK: Bone and Beyond | ESPE2019

“RANKL and RANK: Bone and Beyond”

Penninger Josef

RANKL was identified as an osteoclast differentiation factor as well as a T cell-derived stimulator of dendritic cells. The essential role of RANKL in osteoclastogenesis has been genetically proven in both mice and humans. In addition, RANKL was shown to play a critical role in various tissues including the thymus, gut, and mammary gland. The fully human monoclonal antibody against RANKL, denosumab, has been successfully utilized and approved for the treatment of bone metastas...