ESPE2019 Poster Category 1 Diabetes and Insulin (2) (26 abstracts)
Diabetes Type 2 in Non-Obese Neurologically Impaired Children and Adolescents: A New Emerging Entity?
Valeria Calcaterra 1 , Corrado Regalbuto 2 , Chiara Montalbano 3 , Federica Vinci 4 , Annalisa De Silvestri 5 , Gloria Pelizzo 6 , Hellas Cena 4 & Daniela Larizza 1
1University of Pavia and IRCCS Policlinico S. Matteo, Pavia, Italy. 2University of Pavia, Pavia, Italy. 3IRCCS Policlinico S. Matteo, Pavia, Italy. 4University of Pavia, Pavia, Italy. 5 IRCCS Policlinico S. Matteo, Pavia, Italy. 6Children's Hospital G di Cristina, Palermo, Italy
Background: Insulin resistance (IR) plays a key role in the pathogenesis of type 2 diabetes (T2D). In neurologically impaired (NI) children unfavorable cardio-metabolic risk profile with high prevalence of IR has been reported. We evaluated the prevalence of T2D in NI children and adolescents, in order to define if a dedicated glucose monitoring may be recommended in these subjects.
Patients and Methods: We retrospectively evaluated 63 patients (11.4±4.0) with severe disabilities. Auxological parameters were recorded. Metabolic blood assays included fasting blood glucose (FBG), fasting insulin, triglycerides (TG). IR was detected with the homeostasis model assessment for insulin resistance (HOMA-IR>97.5th percentile for age and sex) and triglyceride-glucose index (TyG index>7.88). Elevated FBG was defined with values >100 mg/dl. T2D was defined according to ADA criteria.
Results: ISI, pathological TyG index and elevated FBG were observed respectively in 41.3%, 63.5% and 11.1% patients. No significant correlation between HOMA-IR and TyG was found (r= 0.17 P=0.20). T2D was diagnosed in 2/63 patients (3.2%; 1 male and female) at the age of 4 and 8 years respectively. Both patients were asymptomatic and diabetes was incidentally detected during a routine checkup. Clinical and biochemical data and treatment following diagnosis was reported in table 2. In both patients, IR or surrogate markers of IR were detected. The prevalence of diabetes was higher in prepubertal compared to pubertal subjects (P=0.03), similarly in males and females (P=0.8).
Conclusions: T2D in NI children and adolescents could represent a new emerging entity in subjects without obesity. Insulin resistance and/or surrogate marker of insulin resistance index may be useful for the early screening of these at-risk disabled populations
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more