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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 1

Diabetes and Insulin (2)

hrp0092p1-308 | Diabetes and Insulin (2) | ESPE2019

ABCC8 MODY in an Obese Adolescent Misdiagnosed with Type 2 Diabetes

Filibeli Berna Eroglu , Çatli Gönül , Manyas Hayrullah , Ayranci Ilkay , Kaya Özge Özer , Dündar Bumin

Introduction: An activating mutations in the ABCC8 gene cause both transient and permanent neonatal diabetes mellitus (DM) or MODY 12. In relation to the variant in the ABCC8 gene, patients may also present with either neonatal hyperinsulinism and/or DM later in life. Besides, the same variant can cause different phenotypic features among family members. Response to the sulfonylurea treatment may vary between patients.<...

hrp0092p1-309 | Diabetes and Insulin (2) | ESPE2019

Level of Glycemic Control in Pediatric Patients with Type 1 Diabetes in Bern: A Cross-Sectional Study

Ch. Zingg Tanja , Dennig Michelle , Sommer Grit , Flück Christa E.

Background: Good glycemic control prevents long-term complications of microvascular and macrovascular diseases in type 1 diabetes (T1DM).We aimed to investigate whether our patients had A1c values <7.5% as recommended by ISPAD and how therapy modality, duration of diabetes and pubertal status affected the metabolic control of our patients. We also set out to compare our quality of care with our results of 2008 and with other publ...

hrp0092p1-310 | Diabetes and Insulin (2) | ESPE2019

Preliminary Results of Public Health Prevention Program for Diabetic Ketoacidosis in Children and Adolescent

Simunovic Marko , Skrabic Roko , Vulic Luka , Unic Ivana , Skrabic Veselin

Objectives: Diabetic ketoacidosis (DKA) is the leading cause of mortality in a type 1 diabetic mellitus (T1DM) in pediatric population. The prevalence of the DKA in the developed world ranges from 15% to 61% and in Croatia it is 33 to 36%. In the past few decades in Europe there have been no significant changes in the prevalence of DKA in patients with newly T1DM. In the previous preventive program known as the "Parma campaign", which was c...

hrp0092p1-311 | Diabetes and Insulin (2) | ESPE2019

Optimisation of Transfection Methods Using DNA, RNA and Protein Formats for CRISPR Cas9 Mediated Gene Knock out in Beta-TC-6 Cells.

Purushothaman Preetha , Walker Amy , Hussain Khalid , Hart Stephen

Background: Beta-tumour cells (βTC) are a group of highly differentiated beta cell lines derived by expression of the SV40 T antigen (Tag) oncoprotein under control of the insulin promoter in transgenic mice. βTC-6 cells exhibit glucose stimulated insulin secretion which makes them a valuable tool in understanding the mechanisms that regulate insulin secretion.The CRISPR/Cas9 genome-editing platform is a versatile and pow...

hrp0092p1-312 | Diabetes and Insulin (2) | ESPE2019

Treatment of Diabetic Ketoacidosis with Sub-Cutaneous Regular Insulin in Non-ICU Setting is Economical and Results in Rapid Recovery

Ayyavoo Ahila , Ravikulan Abhimati , Raghupathy Palany

Abstract: Diabetic ketoacidosis(DKA) is a potentially fatal complication in patients with type 1 diabetes mellitus(T1DM). The mainstay of treatment for DKA is correction of dehydration and correcting hyperglycaemia with insulin. Intravenous(IV) insulin is preferred over subcutaneous(SC) insulin as onset of action is rapid and the dose can be titrated based on blood glucose.Aims: To compare efficacy and hospitalisation co...

hrp0092p1-313 | Diabetes and Insulin (2) | ESPE2019

Familial Versus Non-Familial Type-2 Diabetes Mellitus in Children and Adolescents: Clinical and Biochemical Data.

Alyafei Fawzia , Soliman Ashraf , Sabt Aml , Aldarsy Nagwa

Familial clustering of type-2 diabetes is well-known. In adults, the prevalence of diabetes is higher among patients with diabetic parents. The Framingham offspring study found that maternal and paternal diabetes conferred equal risk for offspring type-2 diabetes.Objectives: We conducted this study to compare the clinical characteristics of children and adolescents with family history of type- 2 diabetes mellitus, in one or both parents,...

hrp0092p1-314 | Diabetes and Insulin (2) | ESPE2019

Comparison Between Patients and Families who Routinely Download Data and Those who do Not Download Data at Home in The Management of Type 1 Diabetes

Ng Sze May , Sultana Perveen , Clemente Marisa , Apperley Louise

Background: In type 1 diabetes (T1D), optimal glycaemic control requires intensive self-management to reduce the risk of complications. While routine downloading and review of blood glucose data is part of clinical practice of healthcare providers in an outpatient setting, patients and families are also educated, advised and encouraged to regularly download and review blood glucose data at home in order to make adjustments to insulin dosing for carbohydrate in...

hrp0092p1-315 | Diabetes and Insulin (2) | ESPE2019

Immune Status in Children and Adolescents with Type 1 Diabetes

Osokina Irina

Introduction: There are the inconsistent data about a role cellular and humoral immunity in pathogenesis of type 1 diabetes mellitus.The aim: The aim of this research was to study features of the immune status and of the activity of metabolic enzymes in lymphocytes of blood in children with type 1 diabetes.Methods: Cellular and humoral immunity parameters were studied in 94 patient...

hrp0092p1-316 | Diabetes and Insulin (2) | ESPE2019

An Evaluation of the Accuracy of a Flash Glucose Monitoring System in Children with Diabetes in Comparison with Venous Blood Glucose

Cao Bingyan , Wang Rui , Gong Chunxiu , Wu Di , Su Chang , Chen Jiajia , Yi Yajun , Liu Min , Liang Xuejun , Li Wenjing

Aims: To evaluate the performance of a factory-calibrated flash glucose monitoring system in children with diabetes compared to venous blood glucose (BG).Methods: A total of 13 hospitalized participants newly diagnosed with type 1 diabetes, aged 1~14 years old, were involved in the study. Sensor glucose measurements on days 2, 3, 6, 7, 12 and 13 of wear were compared with venous BG. During these days, the venous BG ...

hrp0092p1-317 | Diabetes and Insulin (2) | ESPE2019

Unexplained Neonatal Deaths Among Kurdish Consanguineous Families: Importance of Recognizing Congenital Hyperinsulinism and Testing for KATP Channel Gene Variants

Anne Amaratunga Shenali , Tayeb Tara Hussein , Rozenkova Klara , Kucerova Petra , Pruhova Stepanka , Lebl Jan

Context: Neonatal hypoglycemia due to congenital hyperinsulinism (CHI) is a potentially life-threatening condition. Severe forms of CHI, caused by autosomal recessive variants in KATP channel subunit genes (ABCC8, KCNJ11), are more prevalent in regions with high consanguinity. These regions also have a high neonatal mortality rate with many deaths remaining unexplained.Patients and Methods: We analyze...

hrp0092p1-318 | Diabetes and Insulin (2) | ESPE2019

Improving The Transition to Adult Care for Adolescents with Type 1 Diabetes: Effect of Transition Readiness, Self-Efficacy and Diabetes Distress on Glycemic Control During Transition

Alwadiy Faisal , Mok Elise , Dasgupta Kaberi , Rahme Elham , Frei Jennifer , Nakhla Meranda

Aim: The transition from pediatric to adult care is characterized by inadequate medical follow-up, poor self-management, and higher risk for adverse outcomes. We aimed to determine whether self-efficacy, transition readiness or diabetes distress are associated with glycemic control (HbA1c) among adolescents with T1D during the transition period.Methods: Cross-sectional study of adolescents (ages 17 years) with T1D follow...

hrp0092p1-319 | Diabetes and Insulin (2) | ESPE2019

Gene Dosage Changes in the GCK Gene not Detected by Sanger DNA Sequencing in Two Patients with Phenotypic MODY 2

Birkebaek Niels H. , Brusgaard Klaus

Background: Maturity onset diabetes of the young 2 (MODY2) is phenotypically characterized by elevated fasting and post-prandial blood glucose (BG) levels and no diabetes auto-antibodies. Inheritance is autosomal dominant, and it is caused by variants in the glucokinase (GCK) gene with resetting of the pancreatic glucose sensor to a higher level. It is essential to detect MODY 2 patients as they do not require treatment.Objective...

hrp0092p1-320 | Diabetes and Insulin (2) | ESPE2019

Assessment of Vascular Endothelial Dysfunction Using Brachial Artery Flow Mediated Dilatation and Carotid Intima Media Thickness in Children and Adolescents with Type 1 Diabetes

Abdelghaffar Shereen , Mira Marwa , Hashem Rania , Abdalla Maisa

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes. Macro- and micro-vascular complications are involved in the pathophysiology of CVD and the increased risk of developing atherosclerosis in this population. A probable association between type 1 diabetes (Type 1 D) and CVD has been attributed to chronic uncontrolled hyperglycemia, inflammation, endothelial dysfunction (ED), and subclinical manifestations of vascular disease. ...

hrp0092p1-321 | Diabetes and Insulin (2) | ESPE2019

A Case of Late-Onset Monogenic Diabetes Due to a Homozygous Variant in the GCK Gene

Filibeli Berna Eroglu , Çatli Gönül , Ayranci Ilkay , Manyas Hayrullah , Kirbiyik Özgür , Dündar Bumin

Introduction: Heterozygous loss-of-function mutations in the glucokinase (GCK) gene cause MODY 2. Conversely, homozygous loss-of-function mutations in the same gene give rise to permanent neonatal diabetes mellitus (DM). Previously, two patients diagnosed with DM in adolescence and had homozygous GCK mutations were reported. Variants in these patients have been shown to exhibit inactivated kinetics that are indistinguishable from neonatal ons...

hrp0092p1-322 | Diabetes and Insulin (2) | ESPE2019

Neonatal Diabetes and Glis3 Mutation: A New Phenotype

Kamoun Thouraya , Chabchoub Imen , Kmiha Sana , Julier Cecile , Hachicha Mongia

Background: The transcription factor Gli-similar 3 (Glis3) is predominantly expressed in the pancreas and it has a critical role in the development of insulin producing β-cells, thyroid and kidney. Mutations in GLIS3 is a rare cause of neonatal diabetes associated with congenital hypothyroidism, congenital glaucoma and polycystic kidney. We report a new case from consanguineous parents with homozygous novel mutation in GLIS3 gene.<p class="abstext"...

hrp0092p1-323 | Diabetes and Insulin (2) | ESPE2019

Diabetes Type 2 in Non-Obese Neurologically Impaired Children and Adolescents: A New Emerging Entity?

Calcaterra Valeria , Regalbuto Corrado , Montalbano Chiara , Vinci Federica , De Silvestri Annalisa , Pelizzo Gloria , Cena Hellas , Larizza Daniela

Background: Insulin resistance (IR) plays a key role in the pathogenesis of type 2 diabetes (T2D). In neurologically impaired (NI) children unfavorable cardio-metabolic risk profile with high prevalence of IR has been reported. We evaluated the prevalence of T2D in NI children and adolescents, in order to define if a dedicated glucose monitoring may be recommended in these subjects.Patients and Methods: We retrospectivel...

hrp0092p1-324 | Diabetes and Insulin (2) | ESPE2019

Cataract in Type 1 Diabetes Mellitus Patients- a Nationwide Population-Based Study

Chen Li-Min , Lu Wen-Li

Though most ophthalmologic emphasis has been stressed on the influence of retinopathy on the young diabetic community, lesser known is the complication of cataract, which has resulted in more than half of the blindness worldwide. This study attempts to stratify the epidemiology and risk factors of cataract in the type 1 diabetes mellitus (T1DM) population using data extracted from the National Health Insurance Research Database (NHIRD) in Taiwan.A two-st...

hrp0092p1-325 | Diabetes and Insulin (2) | ESPE2019

Association of CTLA-4 Gene with the Familial Diabetes Mellitus

Saatov Talat , Karimov Khamid , Rakhimova Gulnora , Ibragimov Zafar , Ibragimova Elvira , Ishankgodjaev Tokhir , Alimova Nasiba , Abduvaliev Anvar , Shamansurova Zulaykho

The work was initiated to study role of CTLA4 gene in the onset of familial diabetes mellitus. The samples of peripheral blood taken from children (mean age 12.5 years) of patients with type 1 diabetes mellitus and their blood relatives, such as parents and siblings, and apparently healthy subjects were used in the study. Among the recruits, there were 56.5% of boys and 43.5% of girls. The findings from the genotyping of CTLA4 gene 49A/G polymorphism demonstrated no si...

hrp0092p1-326 | Diabetes and Insulin (2) | ESPE2019

Copy Number Variation (CNV) Sequencing Identifies a Novel Mutation of the Glucokinase Gene in Maturity-Onset Diabetes of the Young

Li Yan , Li Pin

Backgrounds: Maturity-onset diabetes of the young (MODY) is a cluster of early-onset, monogenic disorders which is inherited in autosomal dominant form. It is mainly caused by genetic defects in beta-cell, which results in beta-cell dysfunction. Till now, 14 MODY types specified by mutation in respective 14 genes with their etiologies are known. Among them, glucokinase (GCK) gene encodes glucokinase enzyme which plays a crucial role in the regulation of insuli...

hrp0092p1-327 | Diabetes and Insulin (2) | ESPE2019

The Paediatric Diabetes Service in England and Wales – Learning from Sweden's Improvement Journey.

Peng Megan , Warner Justin , Woodhead Tricia , Muszynska Kasia , Eardley Sue , Hopper Neil , Campbell Fiona

A gradual reduction of national median HbA1c levels in England and Wales since 2009 can be attributed to development of a network approach to care supported by the National Paediatric Diabetes Audit (NPDA) and a Best Practice Tariff in England, introduced by the Department of Health in 2012. This delivery of a co-ordinated national programme of support for 173 multi-disciplinary teams distributed across over 140 NHS Trusts and Health Boards, has been at risk of plateauing in r...

hrp0092p1-328 | Diabetes and Insulin (2) | ESPE2019

Creating a Neural Network Model Based on Glycemic Variability Indices to Predict the Degree of Compensation for Type 1 Diabetes

Koshmeleva Marina , Samoilova Juliya , Kobyakova Olga , Oleynik Oxana , Brazovskii Konstantin , Nazarenko Valeriya , Filippova Tatiyana , Podchinenova Dariya

Actuality: Standard methods for determining the compensation of the disease don't always reliably reflect the level of the glycemic control of the patient, which leads to decompensation diabetes and reduce the quality and duration of life for patients. Evaluation of glycemic variability indices allows the physicians to predict the risk of developing life-threatening conditions and compensate the diabetesAim: To condu...

hrp0092p1-329 | Diabetes and Insulin (2) | ESPE2019

Evaluation of AGP Reports in Patients with Type 1 Diabetes Using Intermittently Viewed Continuous Glucose Measurement System (iCGM)

Eren Erdal , Ongen Yasemin Denkboy , Demirbas Ozgecan , Tarim Omer

Introduction: Reduction in glycemic variability and HbA1c levels are achieved by the use of continuous glucose measurement systems (CGM) in the patient with Type 1 diabetes mellitus (T1DM). Intermittently viewed CGM (iCGM) using flash technology have been used increasingly by diabetics and their families because of practicality. Evaluating of ambulatory glucose profiles (AGP) is very important in the management of T1DM.Aim and Me...

hrp0092p1-330 | Diabetes and Insulin (2) | ESPE2019

Evaluation of Clinical, Laboratory and Therapeutic Features and Long Term Follow-up Results in 44 Cases with Genetic Diagnosis of MODY; Single Center Experience

Ozalkak Servan , Keskin Meliksah , Çetinkaya Semra , Erdeve Senay Savas , Bayramoglu Elvan , Aycan Zehra

Introduction-Aim: MODY;It is an autosomal dominant, rare type of diabetes that occurs in young people as a result of mutations of beta cell function and genes involved in insulin secretion. The cases may be misdiagnosed as Type1 and Type2 diabetes. Considering that MODY is clinically and genetically heterogeneous, the findings should be evaluated correctly. It is important to define the clinical-laboratory characteristics of diagnosis and follow-up of patients...

hrp0092p1-331 | Diabetes and Insulin (2) | ESPE2019

Design and Implementation of an Integral System of Clinical Follow-Up and Glucose Monitoring in Children Affected of Type 1 Diabetes, in Andalusia

Hernández-Soto Rocío , Luque-Romero Luis , Alcaide-Gantes Alvaro , Mayoral-Sanchez Eduardo , Romero M del Mar , Dube Juan De Dios , Llamas-Porras Salvador , Sanchez-Laguna Francisco , Antonio Gomez-Palomeque Juan , Martinez-Brocca Asuncion

Introduction: The incorporation of the interstitial glucose monitoring system, in the offer of services in the Andalusian Public Health System (APHS), means an opportunity for the implementation of a model of integration, and follow-up of glucose data, and the evaluation of their impact in health results.Purpose (Aim): The design and implantation of a model that allows the identification, registration of clinical data, i...

hrp0092p1-332 | Diabetes and Insulin (2) | ESPE2019

Targeted Next-Generation Sequencing Demonstrates High Frequency of MODY in Russian Children.

Zubkova Natalia , Laptev Dmitry , Sorokin Daniil , Makretskaya Nina , Petrov Vasily , Vasilyev Evgeny , Tiulpakov Anatoly

Background: Maturity-onset diabetes of the young (MODY) is a heterogeneous group of disorders characterised by autosomal dominant type of inheritance and caused by genetic defects leading to dysfunction of pancreatic beta-cells. At least 13 types of MODY have been described in the literature, the most frequent of which are MODY types 1–3. The frequency of different MODY types in children in Russia has not been studied before.<strong...

hrp0092p1-333 | Diabetes and Insulin (2) | ESPE2019

Abdominal Fat Distribution Assessed by Abdominal CT Scan in Adolescents with Type 2 Diabetes Mellitus

Abe Yuriko , Urakami Tatsuhiko , Hara Mitsuhiko , Yoshida Kei , Mine Yusuke , Aoki Masako , Suzuki Junichi , Saito Emiko , Iwata Fujihiko , Okada Tomoo , Morioka Ichiro

Background: Abdominal fat distributions are reportedly strongly associated with metabolic risks in type 2 diabetes mellitus. However, research on fat distribution in adolescents with type 2 diabetes mellitus has been limited.Aim: To investigate fat distribution characteristics in adolescents with type 2 diabetes mellitus for comparison to those with simple obesity in Japan.Design/Methods</s...