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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 1

Fat, Metabolism and Obesity (2)

hrp0092p1-334 | Fat, Metabolism and Obesity (2) | ESPE2019

ADCY3 Genetic Variants in Cypriot Obese Children

Frixou Maria , Fanis Pavlos , Skordis Nicos , Stylianou Charilaos , Tanteles George A , Toumba Meropi , Neocleous Vassos , Phylactou Leonidas A , Pantelidou Maria

Background: The adenylate cyclase 3 (ADCY3) gene encodes a membrane-associated protein involved in the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This gene seems to be is involved in the regulation of several metabolic processes and has been recently associated to pathophysiological metabolic conditions. Several ADCY3 variants have been linked with obesity in children.M...

hrp0092p1-335 | Fat, Metabolism and Obesity (2) | ESPE2019

The Relationship Between Serum Neurotensin Levels and Metabolic Parameters and Eating Behavior in Obese Children

Tuncerler Gülten , Özyurt Gonca , Uzun Hamide , Çalan Özlem Gürsoy , Küme Tuncay , Dündar Bumin Nuri , Çatli Gönül

Introduction: Neurotensin is a 13 amino acid peptide with central and intestinal effects. It has been shown to decrease intestinal and gastric motility, increase the absorption of fat by regulating the release of pancreas and bile acid. In addition, it is reported that there is also an anorexigenic effect of the neurotensin released from the central nervous system. In the literature, conflicting results related to serum / plasma neurotensin levels were reporte...

hrp0092p1-336 | Fat, Metabolism and Obesity (2) | ESPE2019

Genomic Knowledge as the Powerful Tool to Understand the Obesity

Artuso Rosangela , Pagliazzi Angelica , Palazzo Viviana , Giunti Laura , Landini Samuela , Provenzano Aldesia , La Barbera Andrea , Guarducci Silvia , Pantaleo Marilena , Lucherini Barbara , Sani Ilaria , Vergani Debora , Tiberi Lucia , Formicola Daniela , Bargiacchi Sara , Reho Paolo , Bosi Emanuele , Peluso Francesca , Dosa Laura , Traficante Giovanna , Stagi Stefano , Giglio Sabrina

Obesity, with its complications, emerges as a major contributor to the global health burden becoming pandemic. It's an extremely complex disorder resulting of interaction of biological, social and behavioural factors that cause increase in food intake and reduction in energy expenditure. Although few monogenic forms and indeed several susceptibility loci have been described, the molecular basis underlying early onset obesity remain largely unknown. GWAS revealed consistent...

hrp0092p1-337 | Fat, Metabolism and Obesity (2) | ESPE2019

How does Clusters of Parental Characteristics Influences Offspring Adiposity: A Prospective Study

Ybarra Marina , Meng Lingrui , Zaihra Tasneem , Mathieu Marie-Ève , Barnett Tracie , Henderson Mélanie

Introduction: Childhood obesity rates have increased exponentially in the past three decades. Parental characteristics, such as weight status, physical activity (PA), education and smoking habits have been identified individually as being potential determinants of offspring obesity. However, no prospective studies have examined the joint impact of parental lifestyle habits on their offspring's adiposity. We identified clusters of parental characteristics, ...

hrp0092p1-338 | Fat, Metabolism and Obesity (2) | ESPE2019

Continuous Score of Metabolic Syndrome (sSMp) in Chilean Pediatric Population is Associated with Insulin Resistance Parameters and Subclinical Endothelial Inflammation

Loureiro Carolina , Cavada Gabriel , Bancalari Rodrigo , Vecchiola Andrea , Tapia Alejandra , Baudrand René , Campino Carmen , Carvajal Cristian , Fardella Carlos , Martíinez Alejandro , García Hernán

Introduction: The dichotomous nature of the definition of Metabolic Syndrome (MS) in both children and adults can under-diagnose subjects at risk and prevents adequate follow-up of therapeutic interventions. Recently, a continuous score of MS (sSMp) was validated in the pediatric population based on the IDF criteria for a population> 16 years.Objectives: To apply sSMp in a Chilean pediatric population cohort and corr...

hrp0092p1-339 | Fat, Metabolism and Obesity (2) | ESPE2019

Elevated High-Sensitivity C-Reactive Protein Level is Associated with Prediabetes and Adiposity in Korean Children and Adolescents.

Shin Sohyun , Kim Jaehyun

Objectives: Obesity is a chronic low-grade inflammatory condition that increases the risk of cardiovascular disease. Elevated high-sensitivity C-reactive protein (hs-CRP) has been associated with cardiovascular disease, type 2 diabetes, and metabolic syndrome in adults. We investigated whether hs-CRP represents a risk factor for obesity and cardiometabolic diseases in Korean children and adolescents using nationally representative data.<...

hrp0092p1-340 | Fat, Metabolism and Obesity (2) | ESPE2019

Secular Change in Waist Circumference and Waist-Height Ratio in Korean Children and Adolescents Over 10 Years and Effort to Identity Optimal Cutoff for Cardiometabolic Risk

Kim Se Young , Kim Jae Hyun

Purpose: The aims of this study were to identify the secular changes of WC and WHR, to compare WC with the prior Korean reference, to confirm the distribution of mean WHR values by age and sex, and to determine if WHR cutoff value of 0.5 is an appropriate predicting factor of cardiometabolic risk in childhood, using nationally representative data in children and adolescents.Methods: We performed a retrospective, cross-se...

hrp0092p1-341 | Fat, Metabolism and Obesity (2) | ESPE2019

ANGPTL2 and ANGPTL3 in Children with Obesity and Metabolic Syndrome

Azar Maryam Razzaghy , Nourbakhsh Mitra , Sadeghabadi Zahra Arab , Nourbakhsh Mona

Introduction: Angiopoietin-like proteins (ANGPTLs) play critical roles in metabolism and are implicated in metabolic consequences of obesity. ANGPTL2 is a key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance. ANGPTL3 directly regulate lipid, glucose and energy metabolism independent of angiogenic effects. In this study, we aimed to investigate the levels of ANGPTL2 and 3 in obese children and adolescents and their assoc...

hrp0092p1-342 | Fat, Metabolism and Obesity (2) | ESPE2019

Can Increased First Hour Glucose Concentration in OGTT Be a New Indicator in Projecting Metabolic Profile?

Sahin Nursel Muratoglu , Yilmaz Aslihan Arasli , Özalkak Servan , Aycan Zehra

Aim: Recent studies have shown that the first hour glucose concentration of ≥155 mg / dL in the oral glucose tolerance test (OGTT) in adults with normal glucose tolerance (NGT) may be a strong marker for the development of diabetes, and also an increase in subclinical inflammation, insulin resistance, dyslipidemia and serum transaminases. These results indicate that adults with NGT have increased risk of developing cardiovascular disease and non-alcoholi...

hrp0092p1-343 | Fat, Metabolism and Obesity (2) | ESPE2019

Perinatal Features of Prader-Willi Syndrome: A Chinese Cohort

Yang Lili , Zou Chaochun

Background: Prader-Willi syndrome (PWS) is a rare complex genetic disorder caused by an absence of expression of imprinted genes on the paternally derived chromosome 15q11-q13 region. This study aimed to characterize the perinatal features in a cohort of Chinese individuals with PWS.Methods: We analyzed anonymous data of 134 patients from the PWS Registry in China. Perinatal and neonatal presentations were analyzed, and ...

hrp0092p1-345 | Fat, Metabolism and Obesity (2) | ESPE2019

ANGPTL-4 in Children and Adolescents: Relation to Gender, Puberty and Obesity

Barja-Fernández Silvia , Folgueira Cintia , Castelao Cecilia , Pena-León Verónica , González-Saenz Patricia , Vázquez-Cobela Rocío , Aguilera Concepción M , Gil-Campos Mercedes , Bueno Gloria , Gil Ángel , Moreno Luis , Ruiz-Piñon Manuel , García-Palacios María , Casanueva Felipe F , Dieguez Carlos , Nogueiras Rubén , Seoane Luisa M. , Leis Rosaura

Introduction: Preclinical models demonstrated that Angiopoietin-like protein 4 (ANGPTL-4) regulates lipid metabolism and affects energy homeostasis. However, no data exist regarding its involvement in childhood and adolescence, periods of life with important metabolic changes.Objectives: We aimed to investigate circulating levels of ANGPTL-4 in children and adolescents and its relationship with gender, puberty and obesit...

hrp0092p1-346 | Fat, Metabolism and Obesity (2) | ESPE2019

Non-Invasive Assessment of Liver Steatosis: Usefulness of Elastography in Obese Children – a Pilot Study.

Corica Domenico , Aversa Tommaso , Bottari Antonio , Pepe Giorgia , Morabito Letteria , Curatola Selenia , Spinuzza Antonietta , Alibrandi Angela , Ascenti Giorgio , Wasniewska Malgorzata

Introduction: Non-alcoholic fatty liver disease (NAFLD) is diagnosed in up to 60% of overweight children. Diagnosis and management of NAFLD is challenging due to the lack of non-invasive imaging biomarkers. Ultrasound (US) is the most widely non-invasive method used to identify liver steatosis, however it has low sensitivity to detect mild steatosis and to quantify hepatic fibrosis. Liver Elastography (LE) is a non-invasive methodology used to evaluate hep...

hrp0092p1-347 | Fat, Metabolism and Obesity (2) | ESPE2019

Precocious Pubarche in Spinal Muscular Atrophy Patients with Severe Sarcopenia

Brener Avivit , Lebenthal Yael , Shtamler Anna , Stein Ronnie , Fattal-Valevski Aviva , Sagi Liora

Context: Spinal muscular atrophy (SMA) is an autosomal recessive inherited disease characterized by degeneration of anterior horn cells of the spinal cord and brainstem resulting in variable degrees of muscular atrophy and proximal muscle weakness. In December 2016, nusinersen was FDA-approved for the treatment of SMA in pediatric and adult patients. The introduction of this therapeutic modality has provided a platform for professional medical-care providers i...

hrp0092p1-348 | Fat, Metabolism and Obesity (2) | ESPE2019

Evaluation of the Relationship Between Serum Uric Acid Level and Cardiometabolic Risk in Obese Children and Adolescents

Yilmaz Aslihan Arasli , Sahin Nursel Muratoglu , Bayramoglu Elvan , Özalkak Servan , Erdeve Senay Savas , Çetinkaya Semra , Aycan Zehra

Background: In adult studies, serum uric acid level (SUA) has been shown to be associated with cardiometabolic anomalies of metabolic syndrome such as insulin resistance, hypertension, increased carotid intima thickness, and hyperuricemia is considered as an independent risk factor for atherosclerosis and cardiovascular disease. Early cardiovascular changes in obese children and studies on the relationship between metabolic syndrome and hyperuricemia are quite...

hrp0092p1-349 | Fat, Metabolism and Obesity (2) | ESPE2019

Prevalence of Dyslipidemia in Korean Youth Over 10 Years: Data from the Korea National Health and Nutrition Examination Survey 2008-2017

Lee Jieun , Kim Jae Hyun

Objectives: Dyslipidemia begins and continues in youth and is a major risk factor for adult-onset cardiovascular disease. The aim of this study was to investigate the prevalence and trend of dyslipidemia in Korean youth and its trends for 10 years.Methods: Study subjects were Korean youth aged 10-18 years who participated in the Korea National Health and Nutrition Examination Survey (KNHANES). A total of 7,466 eligible p...

hrp0092p1-350 | Fat, Metabolism and Obesity (2) | ESPE2019

Metabolic Risk in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia

Belcheva Milena , Iotova Violeta , Usheva Nataliya , Bocheva Yana , Popova Ralitsa , Pancheva Ruzha , Hristozova Hristina , Kaleva Valeriya

The aim of this study is to evaluate the modifiable factors of metabolic risk among survivors of childhood acute lymphoblastic leukemia (ALL) treated at a single center in comparison with healthy controls.Forty-seven long-term survivors, aged 9-32 years were compared to 35 age- and sex-matched controls. Anthropometric features and laboratory findings were assessed. The body composition was measured by Dual-energy X-ray absorptiometry (DEXA). The physical...

hrp0092p1-351 | Fat, Metabolism and Obesity (2) | ESPE2019

Congenital Generalized Lipodystrophy Type 4 - New Mutation in the CAVIN1 Gene

Döger Esra , Sezer Abdullah , Ugurlu Aylin Kilinç , Akbas Emine Demet , Perçin Ferda , Bideci Aysun , Çamurdan Orhun , Cinaz Peyami

Introduction: Congenital generalized lipodystrophies (CGL); autosomal recessive disorders characterized by dyslipidemia and almost complete absence of body fat associated with insulin resistance. It develops due to mutations in AGPAT2, BSCL2, CAV1, PTRF, PCYT1A and PPAR, genes.CGL type 4 results from PTRF-CAVIN gene mutation. Unlike classical CGL, myopathy, flat and skeletal muscle hypertrophy, heart rhythm disorders (sudden death) and skeletal abnormalities a...

hrp0092p1-352 | Fat, Metabolism and Obesity (2) | ESPE2019

Paediatric Patients with Type 1 Diabetes Mellitus Exhibit Reduced Brown Adipose Tissue Heat Signature Following Cold Stimulation

Law James , Morris David E. , Robinson Lindsay , Randell Tabitha , Denvir Louise , Symonds Michael E. , Budge Helen

Brown adipose tissue (BAT) is a key component of the body's defence against cold challenge and possesses the ability to convert large amounts of chemical energy to heat, conferred by a unique protein, uncoupling protein (UCP)-1, diverting mitochondrial respiration from the production of adenosine triphosphate. In humans, the largest BAT depot is in the supraclavicular region. Sympathetic nervous system stimulation induces glucose uptake into brown adipose tissue, as does i...

hrp0092p1-353 | Fat, Metabolism and Obesity (2) | ESPE2019

Evaluation of Primary Hypertriglyceridemia Patients: Ethiology, Phenotype, Treatment

Kaplan Emel Hatun Aytaç , Kumru Burcu , Albayrak Hatice Mutlu , Keskin Mehmet , Karaoglan Murat

Introduction: Plasma triglyceride (TG) is formed by an exogenous pathway taken from food and by an endogenous pathway produced from the liver. Primer hypertriglyceridemia occurs by genetic reasons. Higher TG levels occurs in lipoprotein lipase (LPL), ApoC2, ApoA5 gene defects. Secondary hypertriglyceridemia is caused by obesity, insulin resistance, alcohol and some drugs. In that study, we evaluated 10 patients with primer hypertriglyceridemia regards to clini...

hrp0092p1-354 | Fat, Metabolism and Obesity (2) | ESPE2019

Association Between Adiposity Measures and Metabolic Variables in Children and Adolescentswith Obesity

Umano Giuseppina Rosaria , Di Sessa Anna , Cirillo Grazia , Ursi Davide , Marzuillo Pierluigi , Miraglia Del Giudice Emanuele

Childhood obesity has become a major health issue in the last decades. Moreover, identifying a simple, feasible, and valid screening tool to select subjects at higher risk for obesity-related comorbidities has become a challenge. Current guidelines reccommend to use BMI percentile for overweight and obesity diagnosis. However, waist-to-height ratio (WHR) has been associated with the risk of metabolic derangement in children and adolescents with overweight and obesity. In addit...

hrp0092p1-355 | Fat, Metabolism and Obesity (2) | ESPE2019

A Comparison of Insulin Resistance Indices: HOMA and Belfiore in 6-8-Year-Old, Properly Growing Children, Born Small for Gestational Age

Stawerska Renata , Lupinska Anna , Szalapska Malgorzata , Kolasa-Kicinska Marzena , Smyczynska Joanna , Hilczer Maciej , Lewinski Andrzej

Introduction: It is well known that low birth weight in children (born small for gestational age, SGA) predisposes them to the occurrence of obesity, insulin resistance (IR) and lipid disorders, observed even through the whole first decade of life. Thus, early diagnostics and prevention are very important. The HOMA index is used to assess insulin resistance (IRIHOMA). However, in some cases, high, prolonged postprandial insulin secretion is observed...

hrp0092p1-356 | Fat, Metabolism and Obesity (2) | ESPE2019

The «Double Diabetes» in Adolescent with Prader-Willi Syndrome.

Bogova Elena , Shiryaeva Tatyana , Nagaeva Elena , Volevodz Natalya , Peterkova Valentina , Bezlepkina Olga

Background: Prader-Willi syndrome (PWS) is a complex, multisystem disorder that arises from lack of expression of paternally imprinted genes on chromosome 15q11-q13. Its major clinical features include neonatal hypotonia, short stature, developmental delay, hyperphagia, childhood onset obesity, hypothalamic endocrinopathy and characteristic appearance. It is known that due to severe obesity PWS patients are prone to develop type 2 diabetes mellitus (T2DM), whi...

hrp0092p1-357 | Fat, Metabolism and Obesity (2) | ESPE2019

Evaluation of Body Composition and Resting Metabolic Rate in Adolescents with KS

Bespaliuk Daria , Chugunov Igor , Okorokov Pavel , Kareva Maria

Background: Klinefelter syndrome (KS) is a frequent anomaly of sex chromosomes, due to the presence of an extra X chromosome (one or more) in the karyotype 46, XY. This disease is characterized by hypergonadotropic hypogonadism and a high risk of developing disorders of carbohydrate and fat metabolism, despite the absence of a pronounced androgen deficiency in adolescents with KS. There are reports of changes in body composition in adolescents with KS even bef...

hrp0092p1-358 | Fat, Metabolism and Obesity (2) | ESPE2019

Relationship Between RBP4 Level and Two of its Gene Polymorphisms with Body Composition and Metabolic Profile in Obese Children

Pascanu Maria-Ionela , Pop Raluca , Banescu Claudia , Hutanu Adina , Vasilache Simona , Marginean Oana

Background: The role of retinol binding protein 4 (RBP4) in the insulin resistance associated with obesity is still unclear and various studies have analyzed the role of its gene polymorphisms as a potential key to understanding the mechanisms involved.Aim: The current study aimed to analyze the relationship between RBP4 levels, the distribution of two SNP (rs3758539 and rs10882280) and the metabolic, anthropometric para...