Normal IGF-Bioactivity and Low Free IGF-I in Patients with Prader-Willi Syndrome with High Total Serum IGF-I: Immunoreactive IGF-I Concentration Poorly Reflects IGF Bio-Activity and Bio-Availability.
1Dutch Growth Research Foundation, Rotterdam, Netherlands. 2Internal Medicine, Subdiv. Endocrinology, Erasmus University Medical Center, Rotterdam, Netherlands. 3Laboratory for Clinical Chemistry, department of Endocrinology, Erasmus Medical Center, Rotterdam, Netherlands. 4Clinical Chemistry and Hematology, Laboratory of Endocrinology, UMC Utrecht, Utrecht, Netherlands. 5Medical Genetics, Section Metabolic Diseases, UMC Utrecht, Utrecht, Netherlands. 6Academic Center for Thyroid Diseases, Erasmus University Medical, Rotterdam, Netherlands. 7Academic Center for Growth Disorders, Erasmus University Medical Center, Rotterdam, Netherlands. 8Pediatrics, Subdiv. Endocrinology, Erasmus University Medical Center, Rotterdam, Netherlands
hrp0092p1-367