Previous issue | Volume 92 | ESPE2019 | Next issue

58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

Card image cap
The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 1

Diabetes and Insulin

hrp0092p1-25 | Diabetes and Insulin | ESPE2019

Pathogenicity of GCK Gene Mutation c.364C>G (p.Leu122Val)

Crudo David , Walsh Elizabeth , Constantacos Cathrine , Hunter Janel

Background: Over 800 different mutations in GCK gene have been reported in the Human Gene Mutation Database, the vast majority of which result in monogenic diabetes (Maturity Onset Diabetes of the Young, MODY type 2). The missense mutation p.Leu122Val is listed in that database as "disease-causing". However, the National Center for Biotechnology Information ClinVar database (Variation ID 585919) reports that this mutation is of "uncertain ...

hrp0092p1-26 | Diabetes and Insulin | ESPE2019

Myocardial Function in Asymptomatic Children with Type 1 Diabetes

Barakizou Hager , Gannouni Souha

Introduction: Diabetic cardiomyopathy is defined as myocardial dysfunction which is independent from any other ischemic, valvular or hypertensive etiology. It is a multifactorial condition caused mainly by a change in the myocardial structure leading sometimes to fibrosis especially in patients with poor diabetes control.Aim: To assess whether type 1 diabetic children and adolescents have early echocardiographic signs of...

hrp0092p1-27 | Diabetes and Insulin | ESPE2019

A Case of Neonatal Diabetes with Hyperferritinemia: A Distal PTF1A Enhancer Mutation

Arslan Gülçin , ACAR Sezer , Nalbantoglu Özlem , Köprülü Özge , Özkaya Beyhan , De Franco Elisa , Ellard Sian , Özkan Behzat

Introduction: Neonatal diabetes, defined as the onset of diabetes within the first six months of life, is very rare disease. Several genetic factors caused to neonatal disease have been identified to date. PTF1A (pancreatic transcription factor 1a) play a key role in early pancreas development and cerebellar neurogenesis. Biallelic mutations in PTF1A have been reported in patients with pancreatic and cerebellar agenesis, whereas mutations loc...

hrp0092p1-28 | Diabetes and Insulin | ESPE2019

Elevated Anti-tissue Transglutaminase Antibodies in Children Newly Diagnosed with type 1 Diabetes do not Always Indicate Celiac Disease

Paketçi Ahu , Armagan Coskun , Erbas İbrahim Mert , Demir Korcan , Abaci Ayhan , Böber Ece

Introduction: The prevalence of celiac disease is 5–10 times higher in patients with type 1 diabetes mellitus (DM) than in the general population. Therefore, celiac serology should be screened intermittently in type 1 DM patients. However, anti-tissue transglutaminase (anti-TTG) antibody elevation may be detected incidentally at the time of type 1 DM diagnosis and regress spontaneously during follow-up, without medical or dietary interventions.<p clas...

hrp0092p1-29 | Diabetes and Insulin | ESPE2019

What Hypoglycemia Does to the Heart: Impact of Nocturnal Hypoglycemia on Cardiac Repolarization in Diabetic Children

Bachmann Sara , Auderset Anne , Zumsteg Urs , Szinnai Gabor , Donner Birgit

Background: Hypoglycemia is the most common and most feared complication of insulin treated diabetes. Though mostly asymptomatic, nocturnal hypoglycemia can be fatal in rare cases: sudden nocturnal death is more frequent in diabetic patients than in others. It is postulated that hypoglycemia related QTc prolongation contributes to cardiac arrhythmia and can lead to dead in bed.Objective: To evaluate influence of nocturna...

hrp0092p1-30 | Diabetes and Insulin | ESPE2019

Effects of Glypican-4 Protein on INS1E Cell Viability and Insulin Signalling

Buhl Joseph , Garten Antje , Richter Sandy , Kiess Wieland , Penke Melanie

Background: Glypican-4 is a heparan sulphate proteoglycan. In addition to a membrane-bound glypican-4, a soluble form exists. Human and rodent adipose tissue were identified as source of circulating glypican-4. Glypican-4 serum levels are associated with obesity and insulin resistance, as in type 2 diabetes (T2D). Because of its positive effect on insulin sensitivity, glypican-4 might play a role in the development of obesity, insulin resistance, and T2D. We a...

hrp0092p1-31 | Diabetes and Insulin | ESPE2019

Dual Diagnosis of Type 1 Diabetes and ADHD

Mazor-Aronovitch Kineret , Pinhas-Hamiel Orit , Modan-Moses Dalit , Levek Noah , Pivko-Levy Dikla , Miller Shahar , Graph-Barel Chana , Ben-David Rachel Frumkin , Ben-Ami Michal , Stern Eve Z , Gruber Noah , Levy-Shraga Yael , Landau Zohar

Background: Attention-deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder of childhood. Type 1 diabetes (T1DM) is the most common metabolic disease in children. The treatment of T1DM requires high executive functions and requires very intensive treatment that could be an obstacle for patients with ADHD. Dual diagnosis of T1DM and ADHD might affect treatment, control and complications of T1DM. In order to prevent long-term complica...

hrp0092p1-32 | Diabetes and Insulin | ESPE2019

Heterozygous RFX6 Mutation as a Cause of Diabetes Mellitus in a Multigenerational Family

Zuckerman Levin Nehama , Paperna Tamar , Hershkovitz Tova , Mory Adi , Kurolap Alina , Mahameed Jamal , Feldman Hagit Baris , Shehadeh Naim

Background: Monogenic diabetes mellitus (DM) is an early-onset, non- autoimmune diabetes. Genetic diagnosis can personalize patient management and lead to prevention. We describe four generations of DM in one family, caused by a heterozygous mutation in the RFX6 gene. RFX6 (Regulatory factor X, 6) is essential for the development of the endocrine pancreas. Mutations in RFX6 can cause neonatal (Mitchell-Riley syndrome) as well as childhood DM,...

hrp0092p1-33 | Diabetes and Insulin | ESPE2019

Plasma Tocopherols and Carotenes are Decreased in Spanish Children and Adolescents with Insulin Resistance, Independently of Obesity

Rupérez Azahara I. , Lozano Gloria Bueno , Leis Rosaura , Gil-Campos Mercedes , Gil Ángel , Moreno Luis A. , Mesa María D. , Aguilera Concepción M.

Introduction: Childhood obesity and insulin resistance (IR) are rising in prevalence, increasing the future adults' cardio-metabolic risk. One of the potential mechanisms behind these alterations is oxidative stress, fruit of increased free radical production and diminished antioxidant defense. Although low plasma vitamin concentrations and oxidative stress have been observed to be associated with obesity in adults and children, their association with IR i...

hrp0092p1-34 | Diabetes and Insulin | ESPE2019

Serum Dipeptidyl peptidase-4 Activity and its Relation to Insulin Resistance in Type 1 Diabetic Adolescents

Hana Mona , Madani Hanan , Ibrahim Amany , Soliman Hend , Salah Shimaa

Background: Insulin resistance (IR) plays a larger role in type 1 diabetes (T1D) disease process than is commonly recognized. Dipeptidyl peptidase-4 (DPP-4) is an enzyme that is expressed on almost all cell surfaces. It deactivates many bioactive peptides involved in glucose regulation; glucose-dependent insulinotropic polypeptide and Glucagon-like peptide-1.Objectives: This study evaluates serum DPP-4 activity in adoles...

hrp0092p1-35 | Diabetes and Insulin | ESPE2019

The Impact of CGM Availability: Real World Data From a Population Based Clinic

Sanderson Elaine , Smith Grant , Abraham Mary , Jones Timothy , Davis Elizabeth

Real-world studies reporting the impact of continuous glucose monitoring (CGM) in children with Type 1 diabetes (T1D) are limited. In April 2017 CGM became fully subsidised in Australia for children with T1D <21yrs. We report the impact of this in a large population based sample of paediatric diabetes (n=1093). Almost all (99%) children (age < 18yr) with diabetes in Western Australia attend a single paediatric diabetes centre.Pri...

hrp0092p1-36 | Diabetes and Insulin | ESPE2019

Expression of Receptor for Advanced Glycation End-products and its Ligands HMGB1 and s100A12 in Children and Adolescents with New-onset Type 1 Diabetes and in Patients with Longer Disease Duration

Uroic Anita Spehar , Krnic Nevena , Svigir Alen , Putarek Natasa Rojnic

Background: Receptor for advanced glycation end-products (RAGE) is a multiligand receptor up-regulated at sites of inflammation, especially in tissues with accelerated advanced glycation end-products formation. It is additionally stimulated by RAGE ligands S100A12 and HMGB1 released from recruited immune cells thus perpetuating the inflammatory process with a potential role in the development of type 1 diabetes as well as in development in diabetes complicatio...

hrp0092p1-37 | Diabetes and Insulin | ESPE2019

Association of Maternal Depressive Symptoms with Worse Metabolic Control in Adolescents with Type 1 Diabetes

Von Borries Denise , Perez Viviana , Jorge Garcia Hernan , Rumie Karime , Astudillo Patricio , Garcia Hernan

Introduction: Metabolic control (MC) of patients with type 1 diabetes (DM1) is linked with complications in short and long term follow up. Adolescence is a critical period in the treatment of DM1, making it difficult to achieve good MC. Few studies, all conducted in the United States, have shown an association between mother´s depressive symptoms with poorer MC of their adolescent.Objective: To evaluate the associat...

hrp0092p1-38 | Diabetes and Insulin | ESPE2019

The Factors Associated with High Levels of HbA1C in Children and Young People with Type 1 Diabetes Mellitus

Ayoola Omolola , Kendall Deborah

Introduction: Patients with diabetes are encouraged to achieve good glycaemic control to reduce the risks of complications. Many factors are associated with glycaemic control.The objective of this study was to evaluate factors associated with good glycaemic control among a cohort of children and young people with type 1 diabetes in Lancashire United kingdom.Methods: All children and young people wi...