ESPE Abstracts

Introduction: Siberia traditionally belonged to iodine-deficient regions. Cessation of iodine prevention in the 1990-s promoted the increase of iodine deficiency disorders (IDD) in Siberia. For iodine prophylaxis now is used iodized salt, and iodine preparations.

The Aim: To estimate the iodine deficiency, the prevalence of IDD and the effectiveness of iodine prophylaxis in the North of Krasnoyarsk territory.

Methods: We performed a complex investigation of IDD in the North of Krasnoyarsk territory: in the Igarsky, Turukhansky, and Yenisseisky regions. 6180 schoolchildren participated in this survey. In accordance with the WHO recommendations, the assessment included clinical examination, measurement of weight and height; thyroid palpation and ultrasound scan; plasma TSH, T₄ and thyroglobulin (TG); urine samples collected in the field and processed for iodine using conventional technique; the analysis of the results of neonatal TSH - screening.

Results: Our epidemiological studies of IDD revealed a moderate iodine deficiency in the northern regions the Krasnoyarsk territory. The median urinary iodine in prepubertal children varied from 30 to 42 mcg/l. The goiter prevalence varied from 42.5% to 58.4% according to thyroid palpation and ultrasound scan in prepubertal children. The median serum TG was from 14.7 to 31 mcg/1 and also corresponded to moderate iodine deficiency. Analysis of neonatal TSH screening in the Krasnoyarsk region has shown that, in whole, the frequency of neonates with TSH >5 µU/ml was 11.8% (in 2000 was 23.9%). The IDD monitoring showed that median urinary iodine in prepubertal schoolchildren increased up to 115 mcg/1. Thus, IDD prevention in these regions was effective.

Conclusions: Our investigations show that in the North of Krasnoyarsk territory there is a serious natural iodine deficiency influencing the health of the population and demanding continuous adequate iodine prevention to prevent cognitive and psychomotor outcomes.

References:

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2. Osokina IV, Manchouk VT. Iodine deficiency disorders in Siberia. Novosibirsk. Science 2012: 1-153.

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4. Osokina I.V. Neonatal thyroid-stimulating hormone screening as an indirect method for the assessment of iodine status in Central Siberia. International Journal of Diabetes and Metabolic Disorders. 2018. V 3. № 4: 1-3.