Introduction: Siberia traditionally belonged to iodine-deficient regions. Cessation of iodine prevention in the 1990-s promoted the increase of iodine deficiency disorders (IDD) in Siberia. For iodine prophylaxis now is used iodized salt, and iodine preparations.
The Aim: To estimate the iodine deficiency, the prevalence of IDD and the effectiveness of iodine prophylaxis in the North of Krasnoyarsk territory.
Methods: We performed a complex investigation of IDD in the North of Krasnoyarsk territory: in the Igarsky, Turukhansky, and Yenisseisky regions. 6180 schoolchildren participated in this survey. In accordance with the WHO recommendations, the assessment included clinical examination, measurement of weight and height; thyroid palpation and ultrasound scan; plasma TSH, T4 and thyroglobulin (TG); urine samples collected in the field and processed for iodine using conventional technique; the analysis of the results of neonatal TSH - screening.
Results: Our epidemiological studies of IDD revealed a moderate iodine deficiency in the northern regions the Krasnoyarsk territory. The median urinary iodine in prepubertal children varied from 30 to 42 mcg/l. The goiter prevalence varied from 42.5% to 58.4% according to thyroid palpation and ultrasound scan in prepubertal children. The median serum TG was from 14.7 to 31 mcg/1 and also corresponded to moderate iodine deficiency. Analysis of neonatal TSH screening in the Krasnoyarsk region has shown that, in whole, the frequency of neonates with TSH >5 µU/ml was 11.8% (in 2000 was 23.9%). The IDD monitoring showed that median urinary iodine in prepubertal schoolchildren increased up to 115 mcg/1. Thus, IDD prevention in these regions was effective.
Conclusions: Our investigations show that in the North of Krasnoyarsk territory there is a serious natural iodine deficiency influencing the health of the population and demanding continuous adequate iodine prevention to prevent cognitive and psychomotor outcomes.
1. Osokina IV. Epidemiological and Immunogenic Peculiarities of Type 1 Diabetes and Iodine Deficiency Disorders in Central Siberia. PhD thesis. Moscow 2002: 1-289.
2. Osokina IV, Manchouk VT. Iodine deficiency disorders in Siberia. Novosibirsk. Science 2012: 1-153.
3. Osokina IV. Iodine Deficiency in Central Siberia. Exploring, prevention and monitoring. Palmarium academic publishing, Germany 2013: 1-234.
4. Osokina I.V. Neonatal thyroid-stimulating hormone screening as an indirect method for the assessment of iodine status in Central Siberia. International Journal of Diabetes and Metabolic Disorders. 2018. V 3. № 4: 1-3.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology