ESPE Abstracts (2019) 92 P1-151

ESPE2019 Poster Category 1 Thyroid (13 abstracts)

Iodine Status in Newborns and Mothers in Georgia

Ekaterine Patsatsia & Marine Gordzeladze

¹G. Zhvania Pediatric Clinic of the TSMU, Tbilisi, Georgia

Background and Aims: For years Georgia belonged to a iodine deficiency endemic region, though as a result of a long-term actions aimed at improving the iodine status the country today is a non-iodine deficient region. For this reason it was decided to study present iodine status of newborns and their mothers leaving in the capital of Georgia, which is no longer non-iodine region.

Materials and Methods: In total 87 newborns born to euthyroid mothers (TSH – 2.3.±0.7 IU/L) with insufficient (low normal) urine iodine level comprised group (Gr.) 1; 51 newborns born to euthyroid mothers with sufficient urine iodine levels were included into Gr. 2; These investigations were carried out: thyroid ultrasound, blood TSH level, iodine concentration in urine and breast milk in mothers; Besides, In newborns - urine iodine level (with ammonium persulfate method) Iodine concentration in meconium (measured with Scholz kinetic method). Newborn screening for hypothyroidism data was considered (TSH levels were measured on 3-4 post-delivery).

Results: Results achieved show, that in Gr.1 fetal chronic hypoxia is evidently more frequent (18,3 %), than in Gr.2 (3%), (P<0,05),late meconium pass (Gr. 1 -32%, Gr. 2 -1%), TSH (Gr.1 – 4.4±1.4 IU/L; Gr.2 –2.8 ±0.39 IU/L) were statistically higher in Gr.1 newborns, than in Gr.2 ones.

Urine iodine level: Gr. 1 - 9.7 ±0.5 mkg/dl,Gr.2 -11.3 mkg/dl, which was statistically higher in Gr.2 than in Gr.1. Ioduria mediana in Gr. 1 mothers was 13.3±3.1 mkg/dl, while in Gr.2 it was 15,4±1.8 mkg/dl. Iodine concentration in breast milk was statistically lower in Gr.1 (7±0.9 mkg/dl), than in Gr.2 (8,6±0,1 mkg/dl). The results indicate that breast milk iodine mediana is lower, than that in urine.

Iodine concentration is newborns' meconium was statistically lower in Gr.1 babies, that in Gr.2 ones (80±2,3 ng/g vs. 97,5±1,8ng/g), (P<0,05). It was found in those, whose iodine level in meconium and urine was low, relatively high TSH levels were observed.

Conclusion: Meconium iodine level in new directly correlates to breast milk iodine level, and newborns' blood TSH level. Iodine concentration in meconium reflects fetal iodine metabolism integral status.

Volume 92

58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

European Society for Paediatric Endocrinology 

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