ESPE Abstracts (2019) 92 P1-150

Acquired Von Willebrand's Syndrome Caused by Primary Hypothyroidism in a 5-Year-Old Girl

Claire Flot1, Thomas Edouard2, Maïthé Tauber2, Isabelle Oliver2, Segolene Claeyssens3, Frederique Savagner4, Philippe Caron5


1Paediatric Endocrine Unit, Children's Hospital, Purpan University Hospital, Toulouse, France. 2Paediatric Endocrine Unit, Children's Hospital, Purpan University Hospital, Toulouse, France. 3Haemophilia Care Center, Medical Department, Purpan University Hospital, Toulouse, France. 4Biochemistry and Genetic laboratory, Federative institute of biology, Purpan University Hospital, Toulouse, France. 5Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France


Background: Acquired Von Willebrand's syndrome (aVWS) associated with hypothyroidism is rare in children and more often diagnosed during the peripubertal period in the context of Hashimoto's thyroiditis.

Case presentation: A 5-year-old girl was referred to the paediatric haematology unit for rectal bleeding, anaemia, and prolonged activated partial thromboplastin time. Her developmental and learning skills were normal. The physical examination revealed severe short stature (height SDS: -3.6) with overweight (body mass index SDS: 1.8) and clinical sign of hypothyroidism. Laboratory investigation revealed aVWS type 1 associated with severe primary hypothyroidism. Anti- thyroid antibodies were negative and thyroid ultrasound found thyroid hypoplasia in favour of congenital hypothyroidism. Restoration of euthyroidism was associated with increased growth velocity and normalization of coagulation parameters. Conclusion: This report highlights the importance to exclude an underlying pathology (including hypothyroidism) in children with suspected VWS, even in young age.

Keywords: Acquired Von Willebrand's syndrome; Hypothyroidism; Children.

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