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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 3

GH and IGFs

hrp0092p3-138 | GH and IGFs | ESPE2019

Factors Affecting Growth Response to Growth Hormone (GH) Therapy in Children with Short Stature and Normal GH and IGF-I Secretion and no Bone Age Delay

Elawwa Ahmed , Soliman Ashraf , Elalaily Rania

Background: There are inconsistencies in the results reported in a small number of previous studies into growth hormone (GH) treatment of short children with idiopathic short stature (ISS.Patients and Methods: Our study included 20 prepubertal (Tanner 1) or peri-pubertal (Tanner 2) children with short stature (HtSDS < -2) and/or HtSDS > 1SD below their mid parental height SD (MPHtSDS), slow Growth velocity( <...

hrp0092p3-139 | GH and IGFs | ESPE2019

Responses to Growth Hormone (GH) Therapy in Children with Short Stature with Normal GH Secretion and Slow Growth Velocity

Elawwa Ahmed , Soliman Ashraf

Background: Variability still exist about the growth response to growth hormone (GH) therapy in children with idiopathic short stature We describe the growth response to GH therapy ( 0.05 mg/kg/day) for > 2 years in 20 prepubertal children with idiopathic short stature (ISS) who had slow growth velocity ( < -1 SD), normal GH response to provocation and who were significantly shorter than their mid-parents height SDS MPHtSDS (-1 difference).<p class...

hrp0092p3-140 | GH and IGFs | ESPE2019

Assessment of Body Composition of Children with Short Stature on Growth Hormone Therapy and its Relation to Serum IGF-1

El-Hawary Amany , osman Engy , El-Eshmawi Ahmed

Background: Isolated Growth Hormone Deficiency (IGHD) is a common endocrinal cause of pediatric short stature. Growth hormone produces most of its actions via insulin growth factor 1 (IGF-1) which affected in IGHD. GH can affect body composition via its action on body metabolism.Objectives: This study aimed to prospectively assess body composition among IGHD group starting GH replacement and after six month of therapy ve...

hrp0092p3-141 | GH and IGFs | ESPE2019

Treatment Outcome of Growth Hormone in Turner Syndrome Children

Thao Bui Phuong , Dung Vu Chi , Nhu Hoa Pham Thi , Khanh Nguyen Ngoc , Bich Ngoc Can Thi , Mai Do Thi Thanh , Ha Nguyen Thu

Background: Turner syndrome (TS) patients frequently have short stature. Females adults with TS are usually 20 cm shorter than normal females. Growth hormone (GH) can improve final height in TS patients.Objective: To evaluate GH therapy for children with Turner syndrome in term of efficacy and side effectPatient and Method: This serial cases study was done in TS patients in a perio...

hrp0092p3-142 | GH and IGFs | ESPE2019

Pituitary Imaging in 23 Children with Growth Hormone Deficiency

Tahri Abir , Abdellaoui wahiba , Rouf Siham , Latrech Hanane

Introduction: Growth hormone deficiency (GHD) is a non-exceptional cause of short stature. Hormonal evaluation and hypothalamic-pituitary MRI are essential to establish the etiological diagnosis. The objective of our study is to assess the different pituitary lesions found in imaging in a group of children with GHD.Patients and Methods: This is a retrospective longitudinal study of 23 cases of GHD who underwent pituitary...

hrp0092p3-143 | GH and IGFs | ESPE2019

The Convulsions Maze: Epilepsy Versus Hypoglycemia

fawzy Dina

Introduction: Diagnosing a seizure can be tricky. The first thing a doctor should do is to rule out other conditions, such as non-epileptic seizures. One of these conditions may be metabolic disturbance as hypoglycemia. Growth hormone deficiency is commonly presented with short stature during childhood .hypoglycemia is a rare presentation of the disease.Case report: a four year and seven months male child, diagnosed as a...

hrp0092p3-144 | GH and IGFs | ESPE2019

A Case of Paediatric GH-secreting Pituitary Adenoma Apoplexy

Partenope Cristina , Gallo Dario , Pitea Marco , Pajno Roberta , Weber Giovanna , Barera Graziano , Cinzia Pozzobon Gabriella

Background: Paediatric pituitary adenomas comprise rare but challenging pathologies in children and adolescents related to their endocrine and neurological characteristics.Objective and Hypotheses: We aimed to describe a case report of growth hormone (GH)-secreting pituitary adenoma apoplexy.Method: a 11-year-old girl presented with fever, sudden headache with vomiting. She abruptl...

hrp0092p3-145 | GH and IGFs | ESPE2019

Final Adult Height of Children with Idiopathic Short Stature: A Multicenter Study on GH Therapy Alone Started During Peripuberty

Wu Di , Chen Rui-min , Chen Shao-ke , Liu Ge-li , Chen Lin-qi , Yang Yu , Wang Xin-li , Peng Ya-guang , Gong Chun-xiu

Purpose: To evaluate the efficacy of GH in improving FAH in ISS children in a multicenter study.Methods: A real-world observation was carried out. Children with ISS in seven hospitals in China were enrolled. The height gain standard deviation score and the height gain over the target height were evaluated.Results: There were 344 ISS patients (217 boys and 127 girls). The baseline a...

hrp0092p3-146 | GH and IGFs | ESPE2019

Growth Hormone Deficiency after Radiation Therapy for Brain Tumor How to Manage?

Baz Ouidad , Semrouni Mourad , Sakher Samia , Mimouni Zerguini Safia

Introduction: Radiation induced growth hormone deficiency (GHD) is one of several important factors in the aetiology of short stature complicating the treatment of brain tumours in childhood. If such a child is clinically well,shows a poor growth rate and biochemical evidence of GH deficiency,then a 1 year trial of GH is justified.The aim of this study is to evaluate growth and assessed Pituitary function (GH deficiency) in children who ...

hrp0092p3-147 | GH and IGFs | ESPE2019

Vitamin D Status in Patients with Short Stature

Rouf Siham , Abdellaoui Ouahiba , Abdellaoui Ouahiba , Latrech Hanane

Introduction: The relationship between the level of vitamin D and the IGF1 is complex. A normal level of vitamin D is necessary for good bone growth. On the other hand, the normal growth process is affected by the excess or the deficit of growth hormone. Thus, the main purpose of our work is to demonstrate the particularity of the vitamin D status of patients with growth hormone deficiency compared to other causes of short stature.<stron...

hrp0092p3-148 | GH and IGFs | ESPE2019

Short Stature in Children in the Department of Endocrinology in the East of Morocco

Rouf Siham , Abdellaoui Ouahiba , Tahri Abir , Latrech Hanane

Introduction: Statural delay is a common reason for consultation in Endocrinology. It is defined as a length less than 2 DS or a slowdown in growth rate. Etiological research involves anamnestic and clinical data. The biological and radiological explorations permitted to select a primary or secondary etiology taking into account the frequency of idiopathic stature delay. The aim of our work is to analyze the clinical, etiological and evolutionary profile of st...

hrp0092p3-149 | GH and IGFs | ESPE2019

Local Lipoatrophy following Recombinant Human Growth Hormone Administration in Prader Willi Syndrome

Akcan Nese , Bundak Ruveyde

Background: Recombinant human growth hormone (rhGH) is usually administered via subcutaneous injections. Besides well-known adverse events such as peripheral edema, benign intracranial hypertension, and slipped capital femoral epiphysis, a less known and rare side effect is local lipoatrophy, a phenomenon with an incompletely understood pathophysiology. Here, we report a case of Prader Willi Syndrome (PWS) who presented with local lipoatrophy following hGH.</p...

hrp0092p3-150 | GH and IGFs | ESPE2019

Features of Somatropin Replacement Therapy in a Patient with Floating Harbor Syndrome

Berseneva Olga , Bashnina Elena , Turkunova Mariia , Serebryakova Elena

Background: Growth hormone (GH) deficiency in children, confirmed by stimulation diagnostic tests, in some cases is accompanied by low effectiveness of somatropin replacement therapy, which may be associated with rare genetic syndromes.Aim: To study the growth effects of GH therapy in treating a patient with Floating-Harbor SyndromeMethods: A GH deficiency was diagnosed in a patien...