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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

hrp0092p3-249 | Thyroid | ESPE2019

Association of Subclinical Hypothyroidism and Dyslipidemia in Children and Adolescents

Habib Ashkan , Habib Asadollah

Background: Subclinical hypothyroidism (SH) is defined as elevated TSH levels while T4 or FT4 levels are normal. In adults, Subclinical hypothyroidism has been correlated to higher levels of total cholesterol, LDL, non-HDL, TG and lower levels of HDL. Correlation of higher levels of TSH and dyslipidemia in children is controversial. As a result, we designed the study to assess the relation between lipid profile components and TSH levels in children and adolesc...

hrp0092p3-250 | Thyroid | ESPE2019

Evaluation of Clinical, Demographic Data and Treatment Results of Cases with Graves' Disease

Aldemir Sönmez Alev , Mert Erbaş İbrahim , Paketçi Ahu , Acar Sezer , Demir Korcan , Böber Ece , Abaci Ayhan

Introduction: Graves' disease is the most common cause of hyperthyroidism in children and adolescents, characterized by development of stimulant antibodies against thyrotropin (TSH) receptors. Environmental and genetic factors are thought to be responsible in triggering autoimmunity.Materials and Methods: Twenty-nine cases, with Graves' disease diagnosed in Pediatric Endocrinology clinic between January 1999 and ...

hrp0092p3-251 | Thyroid | ESPE2019

A Case of Graves Disease with Negative Thyrotropin Stimulating Antibodies in a Pediatric Patient with Type 1 Diabetes

Burdea Liliana , Robinson Sylvia , Minutti Carla

Background: Graves disease (GD) is an autoimmune condition caused by direct stimulation of the thyroid epithelial cells by thyrotropin (TSH) receptor antibodies (TRAb). The action of TRAb can be stimulating, blocking or neutral. Antibodies with agonist action are also called thyroid stimulating immunoglobulins (TSI). The diagnosis of GD is typically confirmed with TSI titer which is positive in >90% of patients. In patients that have negative TSI, high...

hrp0092p3-252 | Thyroid | ESPE2019

An Unusual Presentation of Hypothyridism: Van Wyk-Grumbach Syndrome

Gargouri Imen , Hadjkacem Faten , Safi Wajdi , Ben Othman Wafa , Charfi Nadia , Rekik Nabila , Mnif Mouna , Abid Mohamed

Introduction: The association of juvenile hypothyroidism, precocious puberty and ovarian enlargement is known as Van Wyk and Grumbach syndrome (VWGS). This diagnosis is considered on the basis of imaging findings and thyroid function analysis.Case report: Herein we report a case of 9 years old girl was referred to the endocrinology department with a suspicion of precocious puberty after having progressive breast enlargem...

hrp0092p3-253 | Thyroid | ESPE2019

Child Thyrotoxicosis Syndrome: Structure and Characteristics

Evsyukova Evgeniya , Kolomina Irina , Bukin Sergey , Kisileva Elena , Latyshev Oleg , Okminyan Goar , Samsonova Lyubov

Objective: To study the structure and characteristics of child thyrotoxicosis syndrome.Materials and Methods: At the 1st stage, medical records of patients treated at the Endocrinology Unit of the Children's Hospital named after Z.A. Bashlyaeva of the City of Moscow in 2014-2018 (n=4530) were analyzed. At the 2nd stage, a primary examination of 106 children 3 to 17 years old with a diagnosis of thyrotoxi...

hrp0092p3-254 | Thyroid | ESPE2019

Encephalitis Associated with Autoimmune Thyroiditis: A Rare Cause of Encephalopathy In Children

Fudvoye Julie , Lebrethon Marie-Christine , Leroy Patricia , Seghaye Marie-Christine , Parent Anne-Simone

A ten year old girl was brought by the emergency mobile service for a persistent status epilepticus despite administration of Diazepam on site. She had presented headaches for the last three days and one episode of fever was suspected but not measured four days earlier. She had one episode of dizziness five days earlier.Persistent status epilepticus required invasive ventilation as well as deep sedation with Levetiracetam, Midazolam, ketamine, phenytoin,...

hrp0092p3-255 | Thyroid | ESPE2019

Association of BMI Z-Score and Subclinical Hypothyroidism in Children and Adolescents

Habib Ashkan , Habib Asadollah

Background: Subclinical hypothyroidism is defined as elevated TSH levels while T4 or FT4 levels are normal. Elevated TSH levels are linked with obesity in adults. In a recent meta-analysis in Iran, 6.1% of children below 18 had obesity. Due to the low number of studies on the subject in children we, designed the study to assess the relation between BMI Z-score and TSH levels in children and adolescence.Method: This c...

hrp0092p3-256 | Thyroid | ESPE2019

Pseudoprecocious Puberty in a Girl with Untreated Acquired Hypothyroidism

Dimitrova-Mladenova Mihaela , Yordanova Desislava , Todorova Zdravka , Dasheva Anna , Stefanova Elisaveta

Background: Hypothyroidism is associated with impared growth and pubertal delay. However, there are female patients with untreated acquired hypothyroidism and paradoxical precocious pubertal signs, which include thelarche, galactorrhoea and menarche. These girls do not have axillary and pubic hair development. The exact mechanism for this pseudoprecocious puberty is not clear. The most probable explanation is that high levels of TSH act through the FSH recepto...

hrp0092p3-257 | Thyroid | ESPE2019

Bilateral Hip Pain as First Symptomatic Expression of Severe Primary Hypothyroidism

Kasongo Laura , Nicolescu Ramona

Introduction: Legg-Calvé-Perthes disease is an idiopathic osteonecrosis of the femoral head with uncoupling of bone resorption and formation, presenting as unilateral involvement in most children. Symmetric involvement suggests other conditions: skeletal dysplasia, osteonecrotic entities including hypothyroidism, Gaucher's disease, glycogen storage defects, sickle cell anemia.Case presentation: We present a case...

hrp0092p3-258 | Thyroid | ESPE2019

The Challenge to Treat Neonatal Autoimmune Hyperthyroidism in a Small Preterm

Lignitz Sarah , Coors Detlef , Pohlenz Joachim

Background: The prevalence of hyperthyroidism in pregnancy is about 0.2%, mostly due to Graves disease. Neonatal autoimmune hyperthyroidism caused by the transplacental passage of stimulatory thyrotropin receptor antibodies (TRAB) of the IgG class is a rare disorder. It occurs in only 2% of the neonates of mothers with Graves disease, is transient and associated with high morbidity and mortality rates up to 25%. Antithyroid drugs are the treatment ...

hrp0092p3-259 | Thyroid | ESPE2019

Graves' Disease in a 3 Year-Old Patient with Agranulocytosis due to Methimazole

Demet Akbas Emine , Kor Yilmaz

Introduction: Graves' disease is the most common cause of hyperthyroidism in children with autoimmune thyroid disease. Clinically, goiter, tachycardia, restlessness, craniosinostosis, hyperactivity, growth retardation, diarrhea may occur.Graves' disease is rare under 4 years of age. Treatment options include antithyroid therapy, surgery, and radioiodine therapy. The most commonly used antithyroid therapy is methimazole and has serious side effects such...

hrp0092p3-260 | Thyroid | ESPE2019

Hashimoto's Thyroiditis in Children: Case Series Report of Three Patients

Trong Thanh Nguyen , Vu Chi Dung , Phuong Thao Bui , Nguyen Ngoc Khanh , Thi Bich Ngoc Can , Thanh Mai Do , Nguyen Thu Ha

Hashimoto's thyroiditis (HT) is most commonly caused by autoimmune thyroid disease and rarely in children. It is characterized clinically by gradual thyroid failure, with or without goiter formation, due to autoimmune-mediated destruction of the thyroid gland involving apoptosis of thyroid epithelial cells. In fact, thyroid function at presentation may significantly vary in the different pediatric reports, ranging from euthyroidism (52.1%) to overt hypothyroidism (41.4...

hrp0092p3-261 | Thyroid | ESPE2019

Mutation of RET Gene Causes Multiple Endocrine Neoplasia Type 2B in an Adolescent: Report of One Case and Literature Review

Zhang Lidan , Guo Yan , Ye Lei , Dong Zhiya , Lu Wenli , Wang Wei , Xiao Yuan

Objective: To summarize the clinical features and genetic characteristics of a patient with multiple endocrine neoplasia type 2B (MEN2B) and to review the literatures.Methods: We summarized clinical features, gene sequencing result, treatment and prognosis of a child suffered with MEN2B who was admitted to the Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine in February 2016. And...

hrp0092p3-262 | Thyroid | ESPE2019

A 12 Year Old Boy with Multifocal Papillary Thyroid Carcinoma

Muz Nataliia , Pakhomova Viktoriia , Sprynchuk Nataliia , Kvacheniyk Dmytro , Bolshova Olena

Thyroid carcinoma in pediatric patients usually manifests as an asymptomatic neck mass, with a reported incidence of cervical lymphadenopathy that ranges from 35-83%.Multifocal involvement of the thyroid gland is a well-recognized feature of papillary carcinoma. The reported frequency is about 20%, with wide variations depending on the extent of the sampling and reporting by the pathologistA 12 year old boy presented with t...

hrp0092p3-263 | Thyroid | ESPE2019

Papillary Thyroid Cancer in Children: Single Center Results

Hatipoğlu Nihal , Direk Gül , Uzan Tatli Zeynep , Gül Şiraz Ülkü , Çiçek Dilek , Gök Ebru , Sarikaya Emre , Kendirci Mustafa , Kurtoğlu Selim

Introduction: Thyroid cancers are rare cancers in children and their incidence is 1.4% in pediatric malignancies. However, its frequency is increasing. While the incidence of prepubertal children is equal among girls boys, it increases with age in female patients. Radiotherapy, which is applied to the neck region, and hashimoto disease are the risk factors. The relationship between Hashimoto's disease and papillary thyroid cancer is thought to be assoc...

hrp0092p3-264 | Thyroid | ESPE2019

Cardiac Tamponade Associated with Hypothyroidism in Rwandan Child

Nyirimanzi Naphtal

We report a case of a child who presented with huge pericardial effusion complicated to cardiac tamponade secondary to primary hypothyroidism. Due to the severity of cardiac tamponade, pericardiocentesis was performed to relieve the compression effect. The child improved with Levothyroxine treatment.Hypothyroidism is a rare cause of pericardial effusion in children. If the pericardial effusion increases in volume, cardiac tamponade with clinical...