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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.


Adrenal Insufficiency: New Mechanisms, New Therapies

hrp0092s7.1 | Adrenal Insufficiency: New Mechanisms, New Therapies | ESPE2019

Novel Interventions to Treat Adrenal Insufficiency

Guasti Leonardo

The generation of functional, long-lived adrenocortical cells through reprogramming from pluripotent stem cells or via lineage conversion strategies, could offer an alternative treatment modality for adrenal insufficiency (AI) due to a variety of causes, such as mutation in steroidogenic enzymes as seen in congenital adrenal hyperplasia (CAH). The recent generation of human induced steroidogenic cells (hiSCs) from fibroblasts, blood- and urine-derived cells established from he...

hrp0092s7.2 | Adrenal Insufficiency: New Mechanisms, New Therapies | ESPE2019

Novel Insights into the Pathophysiology of Adrenal Insufficiency Syndromes

Achermann John

Primary adrenal insufficiency (PAI) is an important diagnosis to make as it is potentially life-threatening and requires urgent treatment. Although most paediatric endocrinologists have experience of more common conditions such as congenital adrenal hyperplasia (CAH) and autoimmune adrenal insufficiency, more than 30 other genetics causes of PAI exist, as well as physical causes such as haemorrhage. Reaching a specific diagnosis for some of these rarer conditions can have impo...

hrp0092s7.3 | Adrenal Insufficiency: New Mechanisms, New Therapies | ESPE2019

Widening the Horizon - Clinical Relevance of Steroid Hormone Pathways

Wudy Stefan A.

While it had been widely believed at the end of last century that most problems in steroid metabolism had already been solved, and not much more significant discoveries were to be expected anymore, recent exciting observations and rediscoveries have initiated a renaissance in steroid metabolism research. These revolutionary findings have often been initially made in animals and have also significantly been driven by new steroid analytical techniques based on mass spectrometry....