ESPE Abstracts (2019) 92 P1-338

Continuous Score of Metabolic Syndrome (sSMp) in Chilean Pediatric Population is Associated with Insulin Resistance Parameters and Subclinical Endothelial Inflammation

Carolina Loureiro1, Gabriel Cavada2, Rodrigo Bancalari3, Andrea Vecchiola1, Alejandra Tapia1, René Baudrand1, Carmen Campino1, Cristian Carvajal1, Carlos Fardella1, Alejandro Martíinez1, Hernán García1

1Pontificia Universidad Católica de Chile, Santiago, Chile. 2Universidad de Chile, Santiago, Chile. 3Santa Maria Clinic, Santiago, Chile

Introduction: The dichotomous nature of the definition of Metabolic Syndrome (MS) in both children and adults can under-diagnose subjects at risk and prevents adequate follow-up of therapeutic interventions. Recently, a continuous score of MS (sSMp) was validated in the pediatric population based on the IDF criteria for a population> 16 years.

Objectives: To apply sSMp in a Chilean pediatric population cohort and correlate it with parameters of Insulin Resistance and subclinical endothelial inflammation.

Subjects and Methods: We studied 385 subjects (47.2% women), of 11.5 ± 2.8 years of age. Anthropometry, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were performed. Insulin, glycemia, triglycerides,HDLcol, LDLcol, GOT, GPT, IL6, PAI-1, usCRP, TNF-alpha and adiponectin were determined and the HOMA-IR was calculated. The sSMp was calculated according to the following formula: sSMp = 2x waist / height + Glicemia (mmmol / l) / 5.6+ Triglycerides (mmol / l) /1.7 + SBP / 130 - HDLcol (mmol / l) /1.02. Pearson correlation (R) was used to evaluate associations between the variables.

Results: 41.51% were overweight and 17.4% were obese. The waist / height ratio was 0.51 ± 0.07, SBP 112.5 ± 13.7 mmHg, blood glucose 85.8 ± 6.2 mg / dL, TG 77 ± 53.6 mg / dL, HDL 50.4 ± 12.1 mg / dL. sSMp correlated positively with age (R = 0.25 **), BMI (R = 0.5 **), PAD (R = 0.28 **), GPT (R = 0.268 **), Insulin (R=0.39**), glycemia (R=0.235**), HOMA (R=0.398**), IL6 (R0.13*), PAI-1 (R0.28 **), usCRP (R=0.22**), adiponectin (R=-0.3 **). **P<0.001, *P<0.05.

Conclusions: To our knowledge, this is the first study that validates sSMp and its association with parameters of Insulin resistance and subclinical endothelial inflammation in the pediatric population. The sSMp constituted by a numerical value represents a practical and simple way of predicting children and adolescents at cardiometabolic risk, escaping the dichotomous nature of the classic definition of MS. Future studies will be necessary to establish a cut-off point for the sSMP, capable of individually validating this prediction.