This study aimed to compare cut-off points corrected for age and gender (CCOP) with fixed cut-off points (FCOP) for fasting plasma insulin and homeostasis model assessment-insulin resistance (HOMA-IR) for the diagnosis of IR in Korean obese children and adolescents and to identify IR applying CCOP and FCOP using as outcome the presence of dyslipidemia and Metabolic syndrome (MetS).
We performed a cross sectional analysis of data from 195 adolescents aged 12-18 years who participated in Korean National Health and Nutrition Examination Survey (KNHANES, 2009-2010). Overweight and obese individuals were defined by BMI z score ≥ 1. IR was defined as two criteria: FCOP and CCOP.
The prevalence of IR using HOMA-IR in FCOP and CCOP was 105 (53.8%) and 53 (27.2%) respectively. The prevalence of IR using fasting plasma insulin was 120 (61.5%)of FCOP and 79 (40.5%) of CCOP. Dyslipidemia, abdominal obesity and MetSwere notassociatedto FCOP or CCOP. Fasting blood glucose remained in normal ranges in all patients with IR.
More cases of IR were detected in FCOP of plasma insulin or of HOMA-IR compared to the CCOP, but were not associated with incidence of metabolic disease. There is no fluctuation of blood glucose in this age group, even though presence of IR, and there is no significant difference in fasting plasma insulin between IR detected by HOMA-IR and by fasting insulin.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology