ESPE Abstracts (2019) 92 P3-120

Toward a Simple Marker of Hepato-Visceral Adiposity and Insulin Resistance:The Z-Score Change from Weight-at-Birth to BMI-in-Childhood

Rita Malpique1, Francis de Zegher2, Cristina Garcia-Beltran 1, Lourdes Ibáñez1

1Pediatric Research Institute Sant Joan de Déu, University of Barcelona, Barcelona, Spain. 2University of Leuven, Leuven, Belgium

Insulin resistance and hepato-visceral (central) fat excess are thought to contribute to an earlier timing of adrenarche/pubarche and puberty/menarche; this earlier timing in turn relates often to a mismatch between pre- and postnatal weight gain, which can be estimated by calculating the Z-score change from birth weight (BW) to body mass index (BMI) in childhood. We tested the hypothesis that this calculation may serve as a proxy of insulin resistance and hepato-visceral adiposity in prepuberty by reappraising a cohort of children (mean age, 8.5 years), born appropriate- (AGA, n=41) or small-for-gestational age (SGA, n=45), followed since birth (n=76) or age 3 years (n=10). Assessments included anthropometry, fasting glucose, insulin, liver volume, and hepatic fat, subcutaneous and visceral fat in the abdominal region (by MRI). Z-score change BW-BMI closely associated to central fat (R=0.74; P<0.0001) and insulin resistance (R=0.71; P<0.0001). This results suggest that Z-score change BW-BMI could be viewed as a simple candidate-marker for hepato-visceral adiposity and insulin resistance in prepubertal children.

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