ESPE Abstracts (2019) 92 P3-128

Lipid and Glucose Profiles in Obese Algerian Children and Adolescents

Soraya Kerkouche, Asmahane Ladjouze, Naima Haddad, Zahir Bouzerar

Paediatric Department of CHU Bab El Oued, Algiers, Algeria

Introduction: Obesity constitutes a risk factor for several early-onset metabolic disorders. The problem is escalating in Africa, where the number of obese or overweight children and adolescents has increased byalmost 50% since 2000 according to World Health Organisation (WHO) data).

Objectives: To determine the lipid and glucose profiles in Algerianchildren adolescents with obesity, defined as body mass index (BMI) >97th centile according to WHO growth data 4≤10 years old, 1>10 years), but never reached the threshold of 126 mg/dl in our population in Algerianchildren adolescents with obesity, defined as body mass index (BMI) >97th centile according to WHO growth data.

Patients and Methods: Retrospective study of obesesubjects aged 5-19 years without known type 1 or 2 diabetesor previous systemic illness, followed in a single center over a 10-yearperiod. Auxological data were collected and compared against WHO reference information. Total cholesterol, high and low density lipoproteins (HDL and LDL),triglyceridemia and fasting plasma glucose (FPG) were measured.

Results: During the periodofjanuary2007-december2018, 231 patients (102F:129M) presented with obesity of whom 50 (28F:22M) were enrolled in the study. At initial assessment mean±SD age was 10.20 ±3.5 years, height138±19 cm, BMI 2.95±0.90. Mediane(range)HDLcholesterol were42mg/dl(15-89) with low levels (<40mg/dl) in 18(36%) patients (6≤10 years,12>10 years). Mediane(range) triglyceride levels were 100,5mg/dl(35_187) with high values (≥150 mg/dl)observed in 12(24%)patients (5≤10 years old, 7>10 year ues≥100 mg/lin 5(10%) patients

Conclusion: Hypo-HDL-cholesterolemiafollowed by hypertriglyceridemia are the most prevalent metabolic abnormalities in our study population, affecting up to a third of patients. While overt diabetes mellitus was not found, 10% of patients had impaired fasting glucose.To reduce the morbidity and mortality inherent to cardio-metabolic risk, it isessential to establish a national strategies to prevent and control obesity in Algerian children .

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