ESPE Abstracts

Background: We investigated the relationship of birth anthropometry with cord blood insulin-like growth factor 1 (IGF-1) and leptin levels in Korean infants born at ≥28 weeks' gestation.

Methods: One hundred five appropriate-for-gestational-age (AGA) infants, defined as infants with birth weights (BWs) between the 10th and 90th percentiles for gestational age, were enrolled. Enrolled infants were stratified into three groups according to gestational age (GA) as follows: 28 to <34 weeks' gestation; 34 to <37 weeks' gestation; and 37 to <41 weeks' gestation.

Results: Between three GA-specific groups, there was significant differences in BW, birth length (BL), head circumference (HC), ponderal index, and cord blood IGF-1 and leptin concentrations (P < 0.05), but not in maternal pre-pregnancy body mass index (BMI), maternal pregnancy BMI, maternal age, and pregnancy-induced hypertension. GA and cord blood IGF-1 and leptin concentrations positively correlated with BW, BL, HC, and ponderal index in the univariate analysis. In the multivariate analysis, cord blood IGF-1 concentrations were independently associated with BW and BL. However, cord blood leptin concentrations were independently associated with BW, but not with BL, HC, and ponderal index.

Conclusions: In this study, fetal weight in the third trimester was independently associated with cord blood IGF-1 and leptin levels, but fetal height was only associated with cord blood IGF-1 level.