Abstract: Background: Makorin ring finger protein 3 (MKRN3) is most common genetic cause of central precocious puberty (CPP) and associated with the initiation of puberty. Although its actual function is veiled. Recent study reported MKRN3 interacted with and suppressed neural pentraxin-1 precursor (NPTX1) activity via polyubiquitination during early puberty in mice.
Objective: The aim of this study was to investigate the correlation between serum NPTX 1 and MKRN3 in CPP girls.
Methods: In this case-control study, we examined 38 girls referred for early breast development (before the age of 8 years). The control group included healthy and prepubertal girls. Anthropometric and hormonal parameters were measured and serum level of NPTX1 and MKRN3 were evaluated by commercial ELISA kit.
Results: Serum MKRN3 level was significantly higher in CPP patients than controls(P < 0.001). In patients, serum NPTX1 level was measured higher than control, there was no statistical difference (P = 0.228). Also, serum NPTX 1 was positively correlated with peak LH (r = 0.338, P <0.05), there was no correlated between NPTX1 and MKRN3 in CPP girls(P = 0.882).
Conclusion: Serum MKRN3 decrease and NPTX1 tends to increase in CPP girls. Although, serum NPTX1 and MKRN3 have no significant association, they are likely to be involved in the onset and regulation of puberty.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology