ESPE Abstracts (2019) 92 P1-56

Carotid Intima-Media Thickness Relates Rather to Epicardial and Perirenal Fat than Total Body Adiposity in Apparently Healthy Children

Anna Prats-Puig1, Silvia Xargay-Torrent2, Maria Camós-Carreras3, Gemma Carreras-Badosa4, Jose-Maria Martinez-Calcerrada4, Elena Riera5, Francis deZegher6, Lourdes Ibañez7, Judit Bassols4, Abel López-Bermejo4

1Department of Physical Therapy, EUSES University of Girona, Girona, Spain. 2Pediatrics, Girona Biomedical Research Institute (IDIBGI),, Salt, Spain. 3Pediatrics, Dr. Trueta University Hospital,, Girona, Spain. 4Pediatrics, Girona Biomedical Research Institute (IDIBGI), Salt, Spain. 5Pediatrics, Salut Empordà Foundation, Figueres, Spain. 6Department of Development & Regeneration, University of Leuven, Leuven, Belgium. 7Endocrinology, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain

Background: Carotid intima-media thickness (cIMT) is a well-known marker of subclinical atherosclerosis. The distribution of adipose tissue among visceral fat reservoirs rather than the total adipose tissue mass is more likely to be related to subclinical atherosclerosis.

Objective: The aim of this study was to determine whether epicardial and perirenal fat are more related to cIMT than body adiposity in prepubertal children.

Methods: cIMT, epicardial and perirenal fat thickness were assessed by ultrasonography in 239 school-age Caucasian children [139 boys and 100 girls; mean age 8.9±0.1 yr] included in a cross-sectional study of cardiovascular risk factors in prepubertal children.

Results: Epicardial and perirenal fat, but not waist or fat mass, were independent predictors of cIMT in all children (β=0.223, P=0.001; β=0.290, P<0.0001, respectively. Total R2=19.1%) as well as in lean (β=0.187, P=0.029; β=0.347 P<0.0001, respectively. Total R2=20.6%) and in obese children (β=0.279, P=0.009; β=0.240, P=0.023, respectively. Total R2=16.2%.).

Conclusions: cIMT relates to epicardial and perirenal fat thickness, rather than to body adiposity, in healthy prepubertal children. Measurement of visceral fat thickness by ultrasonography may serve as a simple tool for cardiometabolic risk assessment in childhood.