ESPE Abstracts (2019) 92 P2-293

Analysis of Diabetes-Associated Autoantibodies in Children and Adolescents with Autoimmune Thyroid Diseases

Artur Bossowski1, Marta Rydzewska1, Justyna Michalak1, Anna Bossowska2, Shu Chen3, Sarah Black3, Michael Powell3, Jadwiga Furmaniak3, Bernard Rees Smith3

1Department of Pediatric Endocrinology, Diabetology with a Cardiology Division, Medical University in Bialystok, Białystok, Poland. 2Division of Cardiology, Internal Affairs Ministry Hospital in Białystok,, Białystok, Poland. 3FIRS Laboratories, RSR Ltd, Parc Ty Glas, Llanishen,, Cardiff, United Kingdom

Background: Zinc transporter 8 autoantibodies (ZnT8Abs) together with glutamic acid decarboxylase autoantibodies (GADAbs), insulinoma antigen 2 autoantibodies (IA-2Abs) and insulin autoantibodies (IAbs) are markers of type 1 diabetes mellitus (T1DM). We studied the prevalence of ZnT8Ab in children with autoimmune thyroid diseases (AITDs) to assess the association of AITDs and T1DM at the serological level.

Methods: The study groups consisted of 44 children with Graves' disease (GD), 65 children with Hashimoto's thyroiditis (HT), 199 children with T1DM with or without AITDs and 58 control children. ZnT8Ab, GADAb, IA-2Ab, IAb, 21-hydroxylase autoantibodies (21-OHAbs) and acetylcholine receptor autoantibodies (AChRAbs) were measured.

Results: ZnT8Abs were found in 4/44 (9.1%) patients with GD, and 4/44 (9.1%) patients with GD were positive for GADAb. Of the 65 HT patients, six (9.2%) were positive for ZnT8Ab, while four (6.2%) were positive for GADAb. In the T1DM group, 128/199 (64%) of the patients were positive for ZnT8Ab, 133/199 (67%) for GADAb and 109/199 (55%) for IA-2Ab. One GD patient and one HT patient were positive for all the four diabetes-associated autoantibodies. Two HT patients were positive for three diabetes autoantibodies. Two GD (4.5%) and five HT (7.7%) patients were positive for 21-OHAb only. None of the patients had AChRAb. In the control group, 2/58 (3.4%) were positive for GADAb and 2/58 (3.4%) were positive for ZnT8Ab.

Conclusions: Diabetes-associated autoantibodies including ZnT8Ab were found in children and adolescents with GD and HT.

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