Background: Detail knowledge of pubertal development mode in girls with Turner syndrome (TS) who underwent hormone replacement therapy (HRT) is benefit for the proposal of an optimal HRT. The study was to study the pubertal development mode of girls with TS who underwent HRT and to evaluate the optimal therapy for sex induction in girls with TS.
Method: We present a retrospective, longitudinal study over the past two decades from The First Affiliated Hospital of Sun Yat-sen University.
Patients: Clinical data from 71 TS patients and two groups of normal Chinese girls.
Results: The total investigation time was 3.00(2.00, 4.66) yrs. The interval of each stage was significantly longer (P <0.001) in the girls with TS than that in the normal Chinese girls except for Tanner stages B2-3 (P = 0.011). With the induction of estrogen, the uterine volume increased significantly when compared with the last stage (B3 vs. 2: Z = -2.031, P = 0.042; B4 vs. 3: Z = -2.273; P = 0.023, ; B5 vs.4: Z = -1.368; P = 0.171).The uterine volumes of the girls with TS in stages B2, 3 were greater than those in the control group (P = 0.046), whereas the uterine volume of the control group was inversely greater than that of the TS group in those who reached stages B4 and 5 (P = 0.034). Paired data of 27 TS girls showed the uterine volume (17.93±9.31ml vs. 13.75 ±6.67ml) and width (2.54±0.66cm vs. 2.22±0.36cm) during artificial cycle increase significantly than that before (t = -2.79 and -2.51, P = 0.01 and 0.018).
Conclusion: HRT leads to normal breast development in girls with TS, half of whom reached Tanner stage B5 in our study, although the uterus eventually developed a suboptimal status. The breast and uterus grew quickly at the beginning of HRT (stages B2-4). An optimal HRT regimen for girls with TS may specifically focus on Tanner stages B2-4 and artificial cycle.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology