Objective: To investigate the early predictors of serum IGF-1, DHEAS, AMH and BMP-6 in rapidly progressive puberty girls.
Methods: 750 cases of central precocious puberty(CPP), early puberty(EP) and rapidly progressive puberty(RPP) in Children's hospital of Soochow university were recruited from August 2017 to December 2018. After follow-up six months to one year, 138 girls were divided into CPP(n=32), EP(n=65)and RPP(n=41). Healthy control group is 33 normal physical examination girls, whose age is 8~9 year old.
All cases were divided into five groups: CPP group, EP-RPP group (early puberty with rapidly progressive group), EP-SPP group (early puberty with slowly progressive group), RPP group (rapidly progressive puberty group) and healthy control group, serum, detail medical history, parent's heights and auxiliary examinations were collected.
Test the serum concentrations of IGF-1 and DHEAS by Chemical Luminescence, test the serum AMH and BMP-6 by Enzyme-linked immunosorbent assay.
The statistical analysis software was SPSS22.0.
Results and Conclusions: The peak value of serum FSH and peak ratio of serum FSH/LH in EP-SPP group is higher than those in EP-RPP group, and there is no significant difference of the peak value of serum FSH between EP-RPP and RPP, indicated that the peak value of serum FSH combine with the peak ratio of serum FSH/LH may be used as the one of the early predictors for RPP.
The value of serum IGF-1 was higher in EP-RPP group than in EP-SPP group, with the puberty rapidly progressed, the value of serum IGF-1 was gradually increased, indicated that IGF-1 was related to the progress of puberty, and may be used as the one of the early predictors for RPP. The optimal cut-off value was 232.5ng/ml, which specificity and sensitivity was 79.00% and 69.00% respectively. Additionally, the value of serum IGF-1 was higher in EP-RPP group, EP-SPP group and CPP group than those in healthy control group, meant that IGF-1 was involved in the initiation of puberty.
DHEAS cannot be used as an early predictors for RPP, it may be related to Tanner staging.
The value of serum AMH and BMP-6 in EP-RPP group, EP-SPP group, RPP group, CPP group and healthy control group were no significant difference.
Early menarche and short stage will also happens in early puberty girls, it is important to observe the progression of puberty.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology