ESPE Abstracts (2019) 92 RFC7.3

Osteopontin as an Early Urinary Marker of Diabetic Nephropathy in Adolescents with Type 1 Diabetes Mellitus

Amany Ibrahim1, Hend Soliman1, Mona Abdullatif2, Aly Sabry3

1The Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU), Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt. 2Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. 3Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Introduction: Patients with type 1 diabetes (T1D) have a higher rate of morbidity and mortality compared with the general population, which varies across countries. Diabetic nephropathy (DN) is a common and serious complication of T1D. Osteopontin (OPN) is a calcium binding phosphoprotein that is expressed in glomerular basement membrane. OPN can be a potential marker of vasculopathy and subclinical atherosclerosis and hence a predictor of DN in T1D patients. The aim of the study is to evaluate urinary OPN as an early marker for DN in children and adolescents with T1D.

Subjects and Methods: This cross-sectional study was carried out on 60 children and adolescent with T1D diagnosed more than 5 years, with age range (7-18 years), they were divided into two groups according to albumin creatinine ratio (ACR), normoalbuminuric: ACR < 30 mg/g (n=30); microalbuminuric: ACR 30-300 mg/g (n=30). Urinary OPN was measured in all T1D patients.

Results: The anthropometric and clinical data among the two patient groups showed no significant difference. Urinary OPN (ng/ml) was significantly higher in microalbuminuric than normoalbuminuric patients (P<0.001). There was significant positive correlation between urinary OPN (ng/ml) and ACR (P <0.001)

Conclusion: Longer duration of diabetes and poor glycemic control are associated with increased risk of developing DN. Urinary OPN can be a noninvasive early marker for DN.

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